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Cell: Continuous progress! Yigong Shi's team uncovered the whole process of combining Alzheimer's important protein gamma secretase with drugs for the first time
Time of Update: 2021-01-16
December 28, 2020, a team from Tsinghua University published a research paper entitled "Structural basis of γ-secretaseion and modulation by small γ drugs" online, which looked at the structural mechanisms of three different GSI inhibitors γ secretion enzymes: S.
study, three different structural mechanisms of GSI γ inhibition of secretion enzymes were reported: Semagacestat, Avagacestat, and L685,458.
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Acta Neuropathologica: Assessing the Consensus Standard for Neuropathology in Post-Death Brain Louis Pathology: A Multi-Center Study
Time of Update: 2021-01-16
currently, neuropathological diagnosis of Louis Body Disease (LBD) can be performed under several sting systems, including Braak-Lewy, McKeith and his colleagues' Consensus Standards (McKeith), Leverenz and colleagues' improved McKeith system, and Beach and his colleagues (Beach' unified sting system).
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Nature Neuroscience: The pre-cortical cortical layer exhibits multi-dimensional dynamic coding during decision-making
Time of Update: 2021-01-16
Surprisingly, contrary to previous studies, our analysis shows that the encoding of decision-making, context and correlation, as well as unrelevant stimuli variables, exhibits rotational dynamics in multi-dimensional subspace, including modulation of two or more orthocisal neural activity patterns over time.
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Brain : The neurology team at Huashan Hospital found that far-end myopathy is the most common disease-caused mutation in China
Time of Update: 2021-01-16
Recently, the research team of neuromyopathy in neurology department of Huashan Hospital affiliated with Fudan University, in cooperation with the National Key Laboratory of Genetic Engineering of Fudan University School of Life Sciences, found that the recurrence abnormal amplification of GIPC1 gene 5' non-translation zone (5'UTR) CGG was negatively related to the disease's high chain, and the number of repeat amplifications was negatively corresed with the age of onset.
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Lancet neurology: The safety and effectiveness of Pernisson in the short-term prevention of seizure congeal headaches
Time of Update: 2021-01-16
of the study was the number of headache attacks in the first week of the treatment compared to the placebo group.
Safety and efficacy of prednisone versus placebo in short-term prevention of episodic cluster headache: a multicentre, double-blind, randomised controlled trial.
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Nano Today: PtCu alloy nanoenzyme is expected to treat Parkinson's disease
Time of Update: 2021-01-16
PtCu NAs reduce PFF-induced reactive oxygen species (ROS), co-pathology and neurotoxicity, and increasing studies have shown that deformed and misfolded α-synaptic nucleoproteins are the culprits of Parkinson's disease, spreading from the intestines to the brain, spreading and sticking together in the brain to form deadly clumps.
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BRAIN: Excision surgery prevents the aggressive cortique of temporal lobe epilepsy from thinning
Time of Update: 2021-01-16
compared to the thinning of the aging-related cortology in healthy subjects, progressive cortitological atrophy was found in a point-by-point analysis prior to TLE surgery, a two-sided lesions located outside the temporal lobes on the same side.
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Science: A new mechanism for synhap damage in Alzheimer's disease, S-nitros cascade reactions, may be important in neuropathology
Time of Update: 2021-01-16
in a new study published in Science on December 3, 2020 under the title Noncanonical transnitrosylation network to synapse loss in Alzheimer's Disease, the laboratory studied the in vitro and in vivo models of AD, and Human AD post-mortem brain tissue reveals that enzymes with different catalytic activities with different biochemical pathways can form an S-nitrosyl cascading reaction that results in AD synapse loss: NO groups are transferred from the de-ubiquitinase Uch-L1 to Cdk5 and then to Drp1.
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BRAIN: Carcinogenic effects of SRSF3
Time of Update: 2021-01-16
it is worth noting that SRSF3 is directly related to the occurrence, development, aggression and patient survival of glioblastoma and represents a new potential therapeutic target for addressing this devastating pathology.
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Stroke : After a stroke, patients treated with atrial fibrillation anticoagulants, small vascular disease increases the risk of stroke recurrence
Time of Update: 2021-01-16
they included 1,419 patients who had had a stroke or TIA and evaluated SVD markers on baseline MRIs: vascular clearance around the substrate nerve section (number ≥11); Micro-hemorrhage of the brain (≥1); lacune; White high signal lesions.
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Sci Adv: Scientists have created a drug delivery nanosysm system that penetrates the blood-brain barrier
Time of Update: 2021-01-16
Our solution is to encapsulate the therapeutic agent into biocompaturable nanoparticles with specific surface proteins, enabling them to be effectively transported to the brain during treatment without being affected by the state of the blood-brain barrier.
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Neurology: When stroke patients want to get a good prognostic, the start time of in-vascular therapy is important
Time of Update: 2021-01-16
scale ratio model is used to calculate the ratio ratio to measure the likelihood that intervention at a given EVT start time will result in a lower MS score.
between 10:20 and 11:34, symptoms start significantly longer until EVT, while t-PA venous thrombosis is significantly lower (P.lt;0.004 and P.012, respectively).
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How is Alzheimer's disease treated? Phase III trials of the AXS-05 are to be carried out
Time of Update: 2021-01-16
Alzheimer's disease is an aggressive neurodegenerative disease that is a common form of Alzheimer's disease characterized by cognitive decline and behavioral and psychological abnormalities, including restlessness.
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The FDA accepted Alkermes' re-submission of a new drug application for APKS 3831 to treat schizophrenia
Time of Update: 2021-01-16
Pharmaceutical Company Alkermes announced today that the U.S. Food and Drug Administration (FDA) has confirmed that it has received a re-submission of the company's application for a new drug for APKS 3831 (olanzapine / samidorphan) (NDA) for the treatment of adults with schizophrenia and adults with schizophrenia type I bipolar disorder.
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Neurology: Pregnancy hypertension and cognitive impairment
Time of Update: 2021-01-16
women with HDP had a g-factor lower than normal blood pressure in pregnant women (the average difference was -0.22, with an average range of -2.06; 1.29]）。 HDP was negatively associated with 15-word learning test results: Instant Recall (-0.25, 95% CI is -0.44 to -0.06) and Delayed Recall (-0.30, 95% CI -0.50 to -0.10).
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If you're not greedy, you're healthy? It doesn't exist!
Time of Update: 2021-01-16
However, a new study published in the Journal of Physiology found for the first time that hand-eye coordination is significantly more sensitive to alcohol, with participants' eye movement, processing of target speed and direction significantly affected when blood alcohol levels (BACs) are as low as 0.015%, which means that visual movement and hand-eye coordination are affected after drinking the second half of the beer.
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Neurology: The effects of A-beta and small vascular disease on cognitive impairment are synergistic
Time of Update: 2021-01-16
only one study has shown that brain A beta and WMH interact with the cognition of svMCI individuals.
the main significance of this study is that SUVR was associated with poor cognitive function in CIND and AD patients, but only in CIND patients, there was an interaction between SUVR and WMH.
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Neurology : In older people with epilepsy, the mortality rate is higher after 5 years
Time of Update: 2021-01-16
this socio-demographic difference has been used to count and describe epilepsy-related mortality in young patients, but little is known about its presence in older people.
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Hypertension: Relationship between blood pressure and brain damage in patients with atrial fibrillation
Time of Update: 2021-01-16
researchers found that 54 percent of patients with white lesions fazekas≥22 percent had large non-cortological or cortological infarction, 21 percent had small non-cortological infarctions, and 22 percent had micro-bleeding.
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BRAIN: Brain TSPO-PET predicts the recurrence of multiple sclerosis
Time of Update: 2021-01-16
study, we examined whether PET's measurable innate immune cell activation predicted the progression of multiple sclerosis.
When evaluating the entire multiple sclerosis queue, baseline innate immune cell activation in normal whiteness is an important predictive indicator of late progress.
