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The study reveals the mechanism of function between severe depression and the intestinal ecosystem
Time of Update: 2020-12-11
According to the World Health Organization, there are about 350 million people suffering from depression worldwide, and in a 2012 report entitled Depression: A Global Crisis, depression has become China's second-largest burden of disease and is expected to rise to the top of the world's burden by 2030.
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A breakthrough has been made in the study of genetic mutations in hereditary colorectal cancer
Time of Update: 2020-12-10
research team, based on the work of pre-image guidance therapy and human sensor network, used clinically collected imaging data, pathological test results and clinical symptoms of patients with chinese familial adenoma pheosa patients, drew blood to extract genomic DNA, and used customized gene fragments.
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Think about science, design the experiment? Go to the journal and register it first!
Time of Update: 2020-12-10
This contribution allows authors to submit their scientific questions and experimental designs to journals for peer review before doing the experiment, and the reviewed report can be "accepted in principle", meaning that the article will be published after a second round of peer review, provided that the study is actually carried out in accordance with the methodology described in the pre-submission report.
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China's prostate cancer precision medicine research has been breakthrough
Time of Update: 2020-12-10
Wang Chen Ji, National Key Laboratory of Genetic Engineering, Fudan University, China, worked with Huang Haojie team of Mayo Medical Center and Sun Yinghao team of Second Military Medical University to achieve important research results in the field of precision medicine for prostate cancer.
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Scientists have made progress in the study of obesity rates from dietary environmental impacts
Time of Update: 2020-12-10
To find out exactly whether and how the dietary environment affects weight, the John Speakman team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences analyzed the relationship between obesity rates in the United States and the distribution density of fast-food and full-service restaurants, and found a lack of correlation.
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Scientists report good ways to build 3D cellular structures
Time of Update: 2020-12-10
published today, an embryonic stem cell (ESC) magnetically driven 3D polymer that forms heart cells.
The authors found that internalizing magnetic iron oxide particles in ESC did not affect their ability to differentiate into different types of cells.
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Progress has been made in the study of whole genome association of schizophrenia in China
Time of Update: 2020-12-10
analysis of the whole genome association study of the Han ethnic group in China and revealing the genetic structure of Chinese group schizophrenia disease, sampling is influenced by population structure and geographical distribution, which may lead to inaccurate correlation.
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Studies have found that tumor bacteria can degrade cancer drugs
Time of Update: 2020-12-10
Ravid from the Weizmann Institute of Science in Israel Although Straussman and colleague Leore analyzed samples of 113 pancreatic cancer tissue, the researchers found that 86 were infected with bacterial types that make cytosine desinease, including bacteria common to E.
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Qian Wenfeng's team revealed the regulation of mRNA levels by synonyms
Time of Update: 2020-12-10
The Qian Wenfeng research team at the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences synthesized 3,556 GFP and 523 TDH3 synonyms in yeast, and found that the use of synonyms can regulate mRNA levels, and further experiments have shown that this regulation may be achieved by affecting the degradation rate of mRNA.
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Worried about affecting your child's neurodevelopment during pregnancy? Scientist: That's not the case
Time of Update: 2020-12-10
study, published in the open-access journal BMC Public Health, suggests that pregnant women who use mobile phones during pregnancy are less likely to have any adverse effects on their child's neurodevelopment.
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Chinese scientists have solved the mystery of the Zika virus that causes the disease
Time of Update: 2020-12-10
Mutations at an amino acid point have led to a significant increase in the toxicity of the Zika virus, which in turn has led to the development of small head disease, Chinese scientists said Tuesday.
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CRISPR technology can study early embryonic development in humans
Time of Update: 2020-12-10
CRISPR-Cas9 genome editing technique has been used to study the role of the OCT4 gene in early human embryonic development, according to a paper published in the British Journal of Science and Technology.
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New technology could make vaccines "multiple inoculations at once"
Time of Update: 2020-12-10
researchers report in the new issue of the American journal that they used PLGA (polylactic acid-hydroxyacetic acid) polymers to make a large number of tiny containers, packed into a combination of vaccines, injected into the human body to achieve multiple releases of the vaccine by precisely controlling PLGA degradation time.
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Scientists have built a new method for artificial sperm-mediated mice that produce point mutations efficiently
Time of Update: 2020-12-10
The researchers first used single-stranded oligopoly nucleotides (ssODN, length 99 bases) with point mutations as repair templates to be transferred to monolithic cells with CRISPR-Cas9, and found that the efficiency of iso-recombinant to obtain cells carrying mutant site decreased dramatically as the distance between the destination mutation site and the Cas9 enzyme cutting site (i.e., the DNA double-stranded disconnect site) increased.
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Fudan University and others to create accurate N-sugar proteomics analysis methods
Time of Update: 2020-12-10
The team of Yang Yanyuan, professor of chemistry at Fudan University, He Simin, researcher of the Institute of Computational Technology of the Chinese Academy of Sciences, and Huang Chaolan, researcher of the National Protein Science Center (Shanghai), worked together to create pGlyco 2.0, a high-volume glyco-based peptide segment analysis method based on mass spectrometrometology, which provides a new technology for precision N-glycoproteomics.
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Gene editing system has universal "brakes"
Time of Update: 2020-12-10
Professor Huang told Science and Technology Daily that their findings predated the Dondner team's report that there was no evidence that ACRII.C1 and ACRII.C3 had a better inhibitory effect than ACRII.C4, but that comparative studies showed that the most effective inhibitors could be found, adding them to the gene editing system, allowing Cas9 to "turn off" the function on time after completing the gene editing task and avoid the off-target effect.
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Healthy overweight people also have a high risk of heart disease
Time of Update: 2020-12-10
even if a person's blood pressure, blood sugar and cholesterol levels are normal, they are overweight or obese, they are more likely to develop coronary heart disease than healthy people of normal weight.
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The United States found the basic pathology of frozen human disease
Time of Update: 2020-12-10
U.S. researchers said in a paper published in the journal on The 16th that they have discovered the basic pathology of amyotrophic lateral sclerosis (ALS): a protein mutation called TIA1 that affects the protein's phase change behavior, causing the death of neurons that control muscles, which in turn leads to ALS.
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Cao Xuetao proposed a new mechanism for the surface regulation of antiviral natural immunity
Time of Update: 2020-12-10
August 29th, a paper by Cao Xuetao, president of the Chinese Academy of Medical Sciences and a member of the Chinese Academy of Engineering, was published, reporting on the results of the study that RNA anti-lysase DDX46 can lead to the retention of the antiviral molecule mRNA nucleus through RNA demethylation modification, which in turn inhibits the natural immune response of antivirals.
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BMC Medicine became the first medical journal to accept contributions in the form of a registered report
Time of Update: 2020-12-10
As one of the top ten leading medical journals, BMC Medicine publishes literature and review articles on the relevance of research and practice in the field of medicine and global health.
