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published today, an embryonic stem cell (ESC) magnetically driven 3D polymer that forms heart cells. Creating 3D tissue structures through individual cells and stimulating them to form specific cell types is an important goal of regenerative medicine.
studies have shown that factors can affect stem cell differentiation, but many are focused on 2D structures. Claire Wilhelm of france's National Centre for Scientific Research and the University of Paris VII and colleagues presented 3D magnetic assembly of ESC structures and telemedicological stimuli for stem cell differentiation. They show that the integration of iron oxide nanoparticles into ESC can be made into such structures. Once magnetized, these cells can be remotely manipulated by magnetic fields to form 3D polymers, which are then differentiated into heart cells by a magnetic stimulus. The authors found that internalizing magnetic iron oxide particles in ESC did not affect their ability to differentiate into different types of cells.
process allows researchers to study the differentiation of ESC without any biochemical triggers, which may represent a new approach to manufacturing 3D tissue structures that are different from traditional techniques. (Source: Zhang Zhang, China Science Daily)
