New compounds make you "beautiful" without sunburn.

a new compound that allows people to have a healthy complexion without sunbathing. However, the compound has not yet been clinically tested and has only been tested in mice and surgically peeled human skin fragments. But doctors hope to one day use it to keep people away from harmful ultraviolet rays, thereby fighting skin cancer.
that there are no safety issues, it is undoubtedly better to use the compound than to be exposed to ultraviolet light. Jerrod Stapleton, a behavioral scientist at the Rutgers Cancer Institute in New Jersey who was not involved in the study, said. Stapleton is dedicated to studying indoor "sunbathing". "What we're talking about is that millions of young people may no longer need sunbeds every year. This will be a changer in the battle against skin cancer. He said.
"inspiration" for this progress came from a "red-headed" mouse with rusty fur. These rodents have a gene called MC1R. The gene can also cause red hair and white skin in humans. The properly acting MC1R gene encodes a receiver called melanin cells located on the surface of skin cells, which convert signals into melanin: these pigments help skin cells resist ultraviolet light. The receiver in the "red-headed" mice failed to respond to signals that produced more melanin, which explains why redheads are more likely to get sunburned than tanned.
, a dermatologist at Massachusetts General Hospital in Boston, thinks he can help people find ways to stimulate melanin-producing pathways in a similar way and turn black. He and Nathanael Gray, a chemist at the Dana-Farber Cancer Institute, target salt-induced kinase (SIK), which is like the main switch of a melanin factory.
they bought a molecule from a chemical supplier that inhibits SIK and applied the liquid compound to "red-headed" mice that had their back hair scraped off. Fishers says that after seven days of daily treatment, the mice's skin began to darken. Moreover, the process is reversible. Under normal conditions, the skin tone of these rodents basically recovers at about 2 weeks.
Fisher said the compound has no obvious safety problems, but more rigorous testing is needed before it can be used in humans.
next step, Fisher and Gray created several new versions of the compound using different chemical modifications to penetrate human skin and experiment with surgically peeled skin debris waste. One of the compounds produces brown plaques, indicating that it can reach melanin cells in the skin and stimulate the production of melanin. The researchers recently published their findings in
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fisher notes that unlike the use of sprays or other treatment-free methods, brown skin produced with the compound looks natural under a microscope. The former relies mainly on dyes to color dead skin cells and does not provide UV protection.
although researchers did not conduct UV experiments on "redhead" mice, melanin is known to provide some UV protection. If the compound is safely used in humans, it will provide an alternative to the "blacks" who illegally use the synthetic hormone melanotan. Meranotan is a drug used in dark skin that has not been fully studied for its side effects, is not licensed in most countries, and has been linked to skin cancer.
, Fisher stressed that the new compound will not replace sunscreen, but can be used at the same time. Also, because the compound makes melanin simple, it should be suitable for any skin type, but it is most helpful for people with white skin at high risk of skin cancer development. Currently, Fisher is looking for collaborators to clinically test the compound.
but even if new compounds can be sold on the shelves, experts warn caution. "I'm worried that these elements will create an unreal sense of security." Jennifer Herrmann, a dermatologist at the Moy-Fincher-Chipps Center for Facial Plastics and Dermatology in California, said. Herrmann studies tanning skin sun-shine accelerators: "If you just turn slightly black, you probably won't give yourself a lot of protection." Sunscreen with low sun protection is also better than tanning skin, she says.
, proper sun exposure is good for your health, but excessive sun exposure is associated with the occurrence of some skin tumors. Excessive sun exposure not only leads to skin aging, color spots, etc., but also may cause photosensitive dermatitis, sun-sensitive ancation, seborrupic analagation and other sun-related diseases, and even increase the risk of tumors, so daily especially in summer should pay attention to sun protection. (Source: Science Network Tang 1 Dust)