A breakthrough has been made in the study of genetic mutations in hereditary colorectal cancer

Recently, Zhao Guoru of the Medical Robotics and Minimally Invasive Surgical Instruments Research Center of the Shenzhen Institute of Advanced Technology of the Chinese Academy of Sciences made a breakthrough in the research field of genotype and epigenetic relationship between gene embryo mutation and familial adenoma bioma disease in group Chinese groups. The work was published
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family adenoma phonosis (FAP) occurs mainly due to mutations in the embryo lineage of the APC gene, with hundreds of pheromones appearing in the human intestine at an early stage, and cancer is inevitable without surgical intervention to remove it. If the cause of an individual's carrying of the APC gene can be detected at an early stage, it is suggested that regular testing to detect precancer lesions early will greatly reduce the incidence and mortality of cancer.
research team, based on the work of pre-image guidance therapy and human sensor network, used clinically collected imaging data, pathological test results and clinical symptoms of patients with chinese familial adenoma pheosa patients, drew blood to extract genomic DNA, and used customized gene fragments. The capture probe obtained 14 genes closely related to hereditary colorectal cancer, compared the original sequencing data into multiple databases, and sequenced the product to verify the results of probe capture and high-volume sequencing. Researchers have discovered a new disease-caused mutation at the APC gene shearing point in a four-generation Chinese family of familial adenoma-based pyropathy.
this study expanded the genotype and esoteric relationship between APC gene embryo mutation and familial adenoma pneumopathy in Chinese groups, and further improved the gene mutation database of Chinese groups of hereditary colorectal cancer