New technology could make vaccines "multiple inoculations at once"

U.S. scientists have developed a "3D weaving" technology that integrates different doses of vaccine packages, released multiple times after a single injection, equivalent to the effect of multiple inoculations.
many vaccines need to be given multiple times according to a specific schedule in order to function, easy to be due to lifestyle, medical conditions and other reasons for leakage. The new technology, which precisely controls the release time of different doses of the vaccine in the human body and replaces multiple vaccinations with one injection, is particularly relevant for immunization efforts in developing countries, according to a new press release from the Massachusetts Institute of Technology.
researchers report in the new issue of the American journal
that they used PLGA (polylactic acid-hydroxyacetic acid) polymers to make a large number of tiny containers, packed into a combination of vaccines, injected into the human body to achieve multiple releases of the vaccine by precisely controlling PLGA degradation time.
PLGA is a medically commonly used polymeric material with good biosynorption, safe degradation in organisms, and degradation time can be precisely controlled by polymer molecular weight and structure.
researchers used photo etching technology to create an array of molds containing about 2,000 units on a glass plate. The PLGA "cups" in the mold can be layered and fused like piles of wood, forming 3D vaccine particles of different sizes. The researchers explain that this new "3D weaving" technology can create complex, sophisticated micro-devices, compared with traditional 3D printing technology is not suitable for such materials, but also difficult to process small devices.
experiments have shown that vaccine particles made with this technology can remain stable in the organism for a long time without pre-leakage and release the vaccine agent at a given time. The researchers designed particles that degraded 9, 20 and 41 days after injection, loaded with egg white protein and injected into laboratory mice, and found that the protein was released as scheduled, triggering a strong immune response that was comparable to the traditional method of multiple injections.
the current particle size is too large, only suitable for under-skin injections, not for intramuscular injections. Researchers are seeking to reduce the size of the particles and further extend their release time, hoping to eventually immunized against a variety of diseases with one injection. (Source: Xinhua News Agency)