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New drug for special dermatitis! Otsuka outside the PDE4 inhibitor defamilast applied for listing, Pfizer similar products Shutanming has been listed in China!
Time of Update: 2020-10-14
currently, Pfizer is also selling Eucrisa (Chinese, a nonsteroidal PDE4 inhibitor-type AD drug with a generic name: crisaborole, creborole, 2% ointment, approved for sale in December 2016 for the treatment of mild to moderate specialty dermatitis (AD) in children and adults aged ≥2 years.
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In patients with insufficient immune response, the effect was better, and the regenerative meta published the preliminary clinical results of the new coronary and antibody therapy.
Time of Update: 2020-10-14
REGN-COV2 was more effective in serologically negative patients, with an average reduction of 0.60 log10 copies/ml of viral load in patients receiving high doses compared to the placebo group.
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Nat Immunol: Key gene regulates immune system 'brake'
Time of Update: 2020-10-14
The integration of the genetic networks of regulatory T-cell biology is the first step in finding drug targets that can alter these cell functions to treat cancer and autoimmune diseases," said Alex Marson, director of the Gladstone-UCSF Institute for Genetic Immunology.
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PLoS Pathog: Oral microbes cause cancer.
Time of Update: 2020-10-14
addition, studies have shown that the formation of pathogen-mediated oral cancer is inhibited by bacterial metabolites, antimicrobial and probiotic peptides produced by a bacterium.
the study provides the first direct evidence that bacterial metabolites inhibit the formation of oral cancer mediated by periodontogens, the authors said.
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Immunity: Natural lymphocyte regeneration mechanism in the lungs.
Time of Update: 2020-10-14
ILC resides in a variety of tissues that interact with many immune and non-immune cell types and contribute to immune surveillance, activation of inflammatory responses, tissue stabilization, repair and barrier function.
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Front in Oncol: Develop a new drug that effectively prevents cancer metastasis or is expected to be a new anti-cancer weapon!
Time of Update: 2020-10-14
researcher Michael Lisanti said: 'We designed and tested a new type of cancer metastase inhibitor based on the current FDA-approved antibiotic, dorcycline, which was approved for use in 1967; Chemical modification of dorcycline increases the potential of its targeted metastasis cancer cells by more than five times, and fortunately, chemical modification also prevents dorcycline from functioning like antibiotics, which effectively reduces the risk of antibiotic-resistant viruses and infections.
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The nutritional intervention method of mouse multiple sclerosis model is proposed.
Time of Update: 2020-10-14
recently, Dr. Chen Wei of the Shanghai Institute of Nutrition and Health of the Chinese Academy of Sciences and others used models of mice with multiple sclerosis to study the interventional effects of intermittent dieting.
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Cancer Immunol Res: Identify new potential targets for the development of new melanoma therapies.
Time of Update: 2020-10-14
researcher Andreas Behren points out that the findings of this paper are very exciting that we are now able to identify specific melanoma stitching peptide molecules in patients with different immunogenics, and based on previous research, the splicing peptide antigen has now changed from an curiosity point in previous immunological studies to a new operational target, not only in melanoma studies, but in other cancer studies.
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Why children are infected with new crowns with lighter symptoms New research reveals key benefits of immune response.
Time of Update: 2020-10-14
" Professor Herold said, "Adult patients have too strong an adaptive immune response, which may promote related inflammation such as acute respiratory distress syndrome." the findings, the researchers suggest that treatments that enhance congenital immune responses in the early stages of the disease may be more helpful.
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NEJM: HPV vaccine is effective in preventing cervical cancer.
Time of Update: 2020-10-14
March 20, 2020 /--- According to a large study published in the journal New England Journal of Medicine by researchers at the Karolinska Institute in Sweden, women who have been vaccinated against HPV have a significantly lower risk of developing cervical cancer, the most significant positive effect for young women.
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STM: Antimalarial drugs help treat diarrhea.
Time of Update: 2020-10-14
the compound was shown to be very effective in killing parasites in cell cultures, the researchers tested it in mice with low immune function from cryptosporidium infection.
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mBio: Can people infected with coronavirus prevent COVID-19?
Time of Update: 2020-10-14
"When we looked at blood samples from people recovered from COVID-19, it looked like many of them already had a pool of memory B cells that could recognize SARS-CoV-2 and quickly produce antibodies that could attack it," said study lead author Dr. Mark Sangster, a professor of microbiology and immunology at URMC.
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In addition to preventing infection, the immune system can also affect the brain and prevent animals from actively "dying"?
Time of Update: 2020-10-14
The scientists showed in mouse experiments that a group of immune cells distributed around the brain releases signaling molecules to nerve cells in the brain, keeping the animals anxious as necessary; led by Professor Jonathan Kipnis of the University of Washington in St. Louis (WUSTL), the team first used techniques such as mass spectrometrometrometular analysis to analyze what immune cells were in the meninges of mice.
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Highlights to be read in the September 2020 journal Science.
Time of Update: 2020-10-14
In a new study, researchers from the United States, France, Belgium and Italy found that a super-powerful antibody mixture from recovering COVID-19 patients identified and blocked the infection complex of the pandemic coronavirus and prevented it from entering cells.
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New advances in the study of clinical therapy for hepatitis C!
Time of Update: 2020-10-14
Ve Chronic HCV Patients with Genotype 3 and Compensated Cirrhosis AbbVie recently announced that the European Commission (EC) has approved the generic hepatitis C therapy Maviret (Chinese commodity name: Enochan, generic name: Gkarive plentawe, The marketing authorization of glecaprevir/pibrentasvir has been changed to reduce the treatment plan for patients with genotype 3 (GT 3) chronic hepatitis C (HCV) who are treated with primary treatment (treatment-naive) and accompaniment cirrhosis from 12 weeks to 8 weeks per day.
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New drug for arthritis in childhood! FDA approves Johnson and Johnson anti-inflammatory drug Simponi Aria :Treatment pJIA and jPsA!
Time of Update: 2020-10-14
September 30, 2020 // -- Johnson and Johnson (JNJ)'s Janssen Pharmaceuticals recently announced that the U.S. Food and Drug Administration (FDA) has approved the anti-inflammatory drug Simponi Aria (golimumab, Golimu monoantigen) for the treatment of polyarthritis (pJIA) and young psoriasis arthritis (jPsA) in patients 2 years of age and older.
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JBC: Treating "gel"-like foreign property in the lungs can help treat Covid-19.
Time of Update: 2020-10-13
8, 2020 /---/ --- In some patients who die of severe COVID-19 and respiratory failure, gel-like foreign property forms in the lungs.
there are already some therapies that can slow down the body's production of gels," said Urban Hellman, a researcher at Umeå University in The University of California, D.C.
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NEJM: Daremu monoantigen or is expected to treat a variety of autoimmune diseases such as systemic lupus erythematosus.
Time of Update: 2020-10-13
6, 2020 // -- In a recent study published in the international journal New England Journal of Medicine, scientists from the Charlett Medical University in Berlin and other institutions successfully tr
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JCI: Previous infection with other types of coronavirus may alleviate the condition of neo-coronary pneumonia.
Time of Update: 2020-10-13
March 20, 2020 /--- -- A new study suggests that a previous infection with the coronavirus that causes the "common cold" may reduce the severity of severe acute respiratory syndrome (SARS-CoV-2) infection.
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NEJM: The experimental new coronavirus vaccine mRNA-1273 has good tolerance and can produce a strong immune response in the elderly.
Time of Update: 2020-10-13
Phase 1 clinical trial of an experimental mRNA vaccine to prevent SARS-CoV-2 infection has shown that it is well-to-do in older adults and produces a strong immune response.
study was recently published in the journal NEJM under the title "Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults".
