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Nat Immunol: Study explains molecular markers of fatal sepsis
Time of Update: 2021-01-20
when cells suddenly rupture, they release not only cytokines, but also other dangerous molecules called "alarm proteins" that warn the body of infection or damage and amplify ongoing cytokine storms.
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JCI: Why does pregnancy increase the risk of organ transplantation?
Time of Update: 2021-01-20
January 5, 2021 // -- A study by the University of Chicago found that while the mother's T-cell response to fetal tissue becomes toned during pregnancy, which helps to make a successful pregnancy, the body fluid response part of the immune system becomes sensitive, leading to the production of memory B cells, which can lead to the displacement of transplanted organs.
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Immunity: Certain lung macrophages can cause severe viral attacks on the lungs
Time of Update: 2021-01-20
a new study, researchers from Sweden's Karolinska Institute describe how different types of immune cells called macrophages are produced in the lungs and which of them can cause serious lung disease.
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Two studies explore the body's unique susceptivity to SARS-CoV-2 variants and vaccines
Time of Update: 2021-01-20
these variants include a special post-translational modification of the rich IgG1 subsype anti-RBD (subject binding domain) antibody, called deyan algae glycosylation.
authors of the two new papers found that patients with severe COVID-19, especially men, were more likely to develop IgG1 antibodies with deyan algae-based Fc polysaccharine.
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The UK became the first country in the world to start getting the new Oxford-AstraZeneta vaccine
Time of Update: 2021-01-20
Brian Pinker, an 82-year-old dialysis patient who was given the first shot at Oxford University Hospital at 7.30am that day, said: 'Doctors, nurses and other staff are doing a great job today and I would love to celebrate our 48th wedding anniversary with my wife later this year.
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J Biomed Mater Res A: Red algae polysaccharies affect the immune system in mice
Time of Update: 2021-01-20
study was recently published in the journal Journal of Biomedical Materials Research Part A under the title "Immunological effects of of Chondrus armatus carrageenans and their low molecular weight products".
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Nat Methods: How do I enhance the effectiveness of T-cell therapy?
Time of Update: 2021-01-19
to this, the team developed a statistical model that combines two existing techniques: TCR analysis (which measures human TCR diversity) and single-cell RNA sequencing (which identifies specific genes that are turned on or off in T cells).
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Cell Host and Micro: Immune globulin IgA or a special microbiome that can target the body of an inflammatory enteropath!
Time of Update: 2021-01-19
Photo Source: pasmov.com In this study, researchers used bacterial fluorescence-activated cell sequencing technology in conjunction with 16S rRNA gene sequencing technology (IgA-SEQ) to analyze IGA coverage of gut microbes in the body of a larger queue of IBD patients, while also identifying specific bacteria associated with disease and therapy.
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Develop a widely used immuno-surveillance technique that may help determine whether an individual's new coronary vaccine is effective and how long the resulting protective force lasts
Time of Update: 2021-01-19
researcher Benjamin Larimer says the diagnostic technique we developed is an accurate and reliable way to help determine whether an individual can be protected against COVID-19, a technique that identifies neutral antibodies in the inoculator's body that block virally infected host cells, and new research suggests that the neutral antibody provides the body with the best protection against the virus, while the most widely used antibody detection methods do not specifically identify neutral antibodies.
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Nat Microbiol: Study reveals characteristics of SARS-CoV-2 infection with primates
Time of Update: 2021-01-19
study is also the first to report that SARS-CoV-2 infection specifically alters lung lymphocytes (T-cells), producing a strong and very specific immune response in macaques that allows animals to remove the virus.
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Nat Med: Breakthrough! Scientists reveal why cancer patients with liver metastasis have poor prognostics!
Time of Update: 2021-01-19
Using a model of cancer mice with liver metastasis, the researchers transported radiotherapy directly to tumors in the liver of mice, which may have blocked the death of T cells; as T-cell function was restored, immunosuppressants activated the immune system to eliminate cancer throughout the body, the same outcome as in patients with non-liver metastasis.
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How can we sleep better and healthier in 2021?
Time of Update: 2021-01-19
January 7, 2021 // -- If you're like the vast majority of U.S. adults, you don't get enough sleep; the new year may be the beginning of a change; the American Academy of Sleep Medicine recommends that
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China's new crown vaccine may be able to effectively resist the SARS-CoV-2 mutant strain
Time of Update: 2021-01-19
Chinese pharmaceutical giant China Pharmaceutical Holdings last week obtained "conditional" approval for its vaccine candidate, and manufacturers said they were confident the vaccine would be effective despite the rapid spread of a new mutation, the SARS-CoV-2 virus.
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Cancer Discovery: Gut microbes promote breast cancer
Time of Update: 2021-01-18
(Photo Source: Www.pixabay.com) Researchers have found that when enterotoxin-fragile Bacillus (ETBF) is introduced into the intestines or breast catheters of mice, it always induces the growth and metastasis of tumor cells.
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The study revealed the mechanism of broad-spectrum protective antibody action of yellow virus targeting NS1
Time of Update: 2021-01-18
Young, Ph.D., In collaboration with Daniel Watterson' research team, a research paper published in Science entitled A broadly protective antibody that targets the flavivirus NS1 protein found a monoclonal antibody 1G5.3 that protects against a variety of yellow viruses, and for the first time revealed the mechanism of NS1 broad-spectrum protective antibodies, pointing out that the yellow virus nonstructive protein NS1 can be a new target for generic vaccine design and effectively avoid ADE effects.
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JAMA sub-journal: Nearly 80% of grynx can be prevented, the key is to control weight!
Time of Update: 2021-01-18
all participants, the above four risk factors were able to prevent 77% (95% CI, 56-88%) of gout attacks!
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Science Immunology: The dark side of cell autophagy helps cancer cells escape immune system damage
Time of Update: 2021-01-18
Using CRISPR screening techniques, researchers found that knocking out an autophagy-related gene called RB1cc1 increased the lethal sensitivity of tumor cells to T cells, thereby enhancing the anti-cancer effect of PD-1 and CTLA-4 checkpoint inhibitors.
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Science Sub-Journal: New study identifies auxiliary T-cells in the lungs that help fight the virus
Time of Update: 2021-01-18
experiments in mice, the researchers described a group of memory T cells in lung tissue called resident auxiliary T cells, which persist long after an influenza attack.
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Lancet Rheumatol: Prognostic trends after infection with new coronary pneumonia in patients with rheumatoid disease
Time of Update: 2021-01-18
researchers used a multi-center, electronic health record network (TriNetX) to conduct a cohort study of patients with rheumatism and musculoskeletal disease diagnosed with COVID-19 infection, comparing the initial 90 days of the pandemic (early queue) with the outcome of the patients in the next 90 days (late queue) (prognosis within 30 days after diagnosis of COVID-19, including hospitalization, intensive care, trachea intestion, kidney failure, and death).
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Cancer Sci: Scientists hope to develop a targeted treatment for many types of cancer - "α-ray missile therapy"!
Time of Update: 2021-01-18
researcher Professor Kazuko Kaneda-Nakashima said: 'We found that 211At-labeled α-methyl-L tyrosine (211At-AAMT) has a high affinity for LAT1, which effectively inhibits tumor cells and promotes DNA double-stranded fragmentation in-body.