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January 5, 2021 // -- A study by the University of Chicago found that while the mother's T-cell response to fetal tissue becomes toned during pregnancy, which helps to make a successful pregnancy, the body fluid response part of the immune system becomes sensitive, leading to the production of memory B cells, which can lead to the displacement of transplanted organs.
the study was published on January 4, 2021 in the journal Clinical Investigation.
(Photo Source: www.pixabay.com) The new study was inspired by previous work that showed T-cells were resistant during pregnancy, meaning they could not react to fetal antigens.
, a professor of surgery at the University of Chicago, said: "This contradicts research in the field of transplantation, in which we believe that pregnancy can lead to allergic reactions.
study, researchers examined the immune response of female mice after transplanting the heart from their offspring.
they found that T cells did not respond to allogeneic transplants, while memory B cells responded to allogeneic grafts, resulting in antibodies against foreign antigens from the transplanted heart.
is essential for mothers to produce antibodies against infectious pathogens during pregnancy and breastfeeding;
, the immune system will produce antibodies to any foreign body that appears during this time, including the antigens expressed by the fetus.
" these results offer new hope for effectively avoiding transplant rejection in pregnant women.
, however, it is not clear how the allergicity of body fluid reactions overrides T-cell tolerance, leading to rejection of allogeneic transplantation in the post-pregnancy population.
() Source: clues on why pregnancy may may have been risk of organality original origin: Ashley N. Suah et al, Pregnancy-induced humoral sensitization overrides T tolerance to fetus-matched allografts in mice, Journal of Clinical Investigation (2021). DOI: 10.1172/JCI140715