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January 7, 2021 // -- A microbe commonly found in the colon associated with the development of colitis and colon cancer may also play a role in the development of certain breast cancers, according to a new study by the Johns Hopkins Kimmel Cancer Center.
breast tissue cells exposed to the toxin retain long-term memory and increase the risk of disease.
(Photo Source: Www.pixabay.com) Researchers have found that when enterotoxin-fragile Bacillus (ETBF) is introduced into the intestines or breast catheters of mice, it always induces the growth and metastasis of tumor cells.
results were published in the recent issue of Cancer Discovery.
, a professor of oncology at Johns Hopkins University School of Medicine and senior study author, said that while microbes are known to exist in body parts such as the gastrointestinal tract, nasal passages and skin, breast tissue has only recently been considered sterile.
Sharma said the study was the first step in demonstrating ETBF's involvement in breast cancer development.
further research is needed to clarify how ETBF moves throughout the body, whether ETBF is the only driver that directly triggers the transformation of human breast cells, and/or whether the microbiome is also carcinogenic to breast tissue.
"Despite a number of identified risk factors for breast cancer, such as age, genetic changes, radiation therapy, and family history, there are still significant breast cancers in women who do not have these factors."
another risk factor, the microbiome, " Sharma said.
if the microbiome is disturbed, or if it carries cancer-causing microorganisms, it can be considered another risk factor for breast cancer.
" Sharma and colleagues conducted experiments to study the effects of ETBF.
, they analyzed clinical data and looked at published studies comparing benign and malignant breast tumors in breast cancer survivors and healthy volunteers with the microbial composition of nipple suction.
was always detected in all breast cancer tissue samples and in the pap lotions of cancer survivors.
in the lab, the team fed the ETBF bacteria through the mouth to a group of mice.
first, it proliferates in the intestines.
, within three weeks, the mouse breast tissue undergone changes usually visible in catheter hyperplies (precancerog state).
In other tests, the researchers found that within two to three weeks of injecting ETBF bacteria directly into the nipples of mice, there were similar signs of growth, and that toxin-exposed cells always showed faster tumor development and more aggressive tumors than unencumbered cells.
exposed to toxins.
cells exposed to the toxin for 72 hours retained the toxin's memory and were able to begin cancer development and develop metastases in different mouse models.
also found that Notch1 and β-catenin cell signaling pathlines were associated with promoting the role of EBFT in breast tissue.
in clinical studies, researchers have begun looking for changes in the microbiome in breast cancer patients to understand how it affects tumor progress and how it responds to treatment.
"We should definitely strive to maintain a healthy microbiome, including eating healthy and exercise, and maintain the correct body mass index."
() Source: Gut microbe may promote breast cancers Source: Sheetal Parida et al. A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes, Cancer Discovery (2021). DOI: 10.1158/2159-8290.CD-20-0537