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The latest developments in the field of scleroderma can be clarified in one article!
Time of Update: 2021-04-18
Figure 3 JSSc diagnosis and treatment process Tofacitinib research study found that for patients with progressive skin sclerosis and refractory diffuse SSc (dcSSc), tofacitinib is as effective as or even better than conventional immunosuppressive agents, with faster onset.
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GLP-1/GCG dual agonist!
Time of Update: 2021-04-17
April 14, 2021 // - Boehringer Ingelheim and Zealand Pharmaceuticals recently announced the launch of two phase 2 clinical trials to evaluate GLP-1/glucagon (GCG) dual The agonist BI456906 is used to treat overweight or obese adults and to treat non-alcoholic steatohepatitis (NASH) adults.
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Nat Commun: Type I interferon promotes the occurrence and development of patients with systemic lupus erythematosus
Time of Update: 2021-04-17
Previous studies have shown that most SLE patients are accompanied by high expression of ISG (type I IFN stimulating gene).
1038/s41467-021-22312-y">Type I interferons affect the metabolic fitness of CD8+ T cells from patients with systemic lupus erythematosus .
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Arthritis Rheumatol: Type I interferon plays a key role in the development of cardiovascular disease in patients with systemic lupus erythematosus
Time of Update: 2021-04-17
Compared with healthy controls, the expression levels of NET complex and IL-10 in patients with systemic lupus erythematosus were up-regulated (P <0.
Compared with baseline, the inhibition of type I IFN receptor by anifrolumab significantly reduced the levels of NET complex and GlycA, and improved the expression of CEC (P <0.
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The world's first innovative dual-target biological agent for the treatment of systemic lupus erythematosus (SLE), Tatacept is the first to be launched in China!
Time of Update: 2021-04-17
Yu "wolf" has the skill, China embarks on a new journey of SLE dual targetYu "wolf" has the skill, China embarks on a new journey of SLE dual targetThe world's first innovative dual-target biological
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Nat Cancer | Han Jichang and others reveal the long-acting anti-tumor immune protection mechanism in survivors of malignant melanoma after immunotherapy
Time of Update: 2021-04-14
Editor | xi The occurrence and development of tumors are not only related to tumor cells themselves, but immune cells in the tumor microenvironment are also closely related to tumor growth and treatm
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With this kind of rheumatism, you are not far from the tumor?
Time of Update: 2021-04-14
Wu Chanyuan from Peking Union Medical College Hospital reported on inflammatory diseases based on the National Rheumatism Data Center (CRDC) The progress in 2020 introduces the current status of my country's idiopathic inflammatory myopathy (IIM), analysis of IIM organ involvement based on CRDC, research on the pathogenesis of IIM and progress in treatment.
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Nat Immunol | Targeting IL-22 to reverse chronic disease-induced anemia
Time of Update: 2021-04-14
Next, the authors tried to confirm whether the anemia caused by a single dose of RIOK2 was secondary to the differentiation defect of bone marrow-derived erythroid cells.
The author also verified the differentiation defect of bone marrow erythroid cells in single knockout mice using the acute hemolytic stress model.
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Nat Microbio: Candida infection triggers the protective immune response of vaginal epithelial cells and the mechanism of tissue repair
Time of Update: 2021-04-14
In contrast, host cells are uniform to all species in the early stages of infection, and are characterized by a protective type I IFN response induced by mitochondrial sublethal signaling.
1038/s41564-021-00875-2 Candida pathogens induce protective mitochondria-associated type I interferon signalling and a damage-driven response in vaginal epithelial cells Nat Microbiol
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Spanish expert: pregnant women vaccinated can help neonatal immunization
Time of Update: 2021-04-14
html">Immunology Carbonello said that if this theory is correct, then in the future, as long as pregnant women are vaccinated with a new coronavirus vaccine that does not carry the virus, the newborns will be immune to protection at the same time.
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Is RA treatment up to standard? Is it enough to just look at the inflammatory indicators?
Time of Update: 2021-04-14
A few days ago, at the 3rd Peking University Rheumatism and Immune Hotspot Forum, Professor Li Mengtao from Peking Union Medical College Hospital mainly introduced the specific standards for the treatment of rheumatoid arthritis (RA), which is a composite index composed of the following three indicators: inflammatory markers, disease Activity, patient report outcome (PRO).
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Science: Artificially design the assembly and modularization of antibody molecules
Time of Update: 2021-04-14
abd9994 For this problem, Professor Baker and others hope to assemble antibodies into precise structures with different valences and symmetry through advanced technologies in computational biology and protein synthesis.
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Li Xiangkai’s team from Lanzhou University found that Lactobacillus in Northwest Gourmet syrup may lower uric acid
Time of Update: 2021-04-14
iNature's purine-rich foods are not completely degraded into uric acid (UA) in the human body, resulting in a high content of UA in plasma, which is considered to be an important risk factor for diseases such as gout.
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Nat Genetics | Huang Ying/Li Dali and others identify gain-of-function mutations in SYK gene that cause human immune disorders
Time of Update: 2021-04-14
Professor Huang Ying from the Department of Gastroenterology, Pediatric Hospital of Fudan University, Professor Li Dali from the School of Life Sciences, East China Normal University, and Professor Aleixo Muise from the Hospital for Sick Children Hospital of the University of Toronto are the corresponding authors of the paper.
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Milestone progress in allergic diseases, the world's first Artemisia pollen sublingual immunotherapy drug was launched
Time of Update: 2021-04-13
April 2, 2021, China sublingual desensitization Forum in Shanghai was held, the forum announced the world's first for the treatment of Artemisia annua allergic rhinitis / mugwort pollen allergy caused by (or associated with conjunctivitis) of standardization The desensitization drug- Artemisia annua pollen allergen sublingual drops was approved for marketing.
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Can rheumatism patients get the new crown vaccine? Do I need to adjust the medication before and after vaccination?
Time of Update: 2021-04-13
2. Due to the heterogeneity caused by disease and treatment-related factors, combined with the influence of age and gender, compared with the general population, patients with rheumatism have a higher risk of hospitalization for new coronary pneumonia and a worse outcome.
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Cell Death Differ: NDP52 mutation can promote mitochondrial autophagy and inhibit the inflammatory response in multiple sclerosis
Time of Update: 2021-04-13
immunityPrevious studies have shown that multiple sclerosis is a disease related to abnormal mitochondrial function , and the role of mitochondrial autophagy in MS is still unknown.
1038/s41418-021-00766-3">Characterization of a natural variant of human NDP52 and its functional consequences on mitophagy .
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Nat Immunol: Defects in TAP function promote atypical cross-presentation and T cell activation
Time of Update: 2021-04-13
(Figure 2, TAP defect does not affect the cross-presentation of dendritic cells) On this basis, the authors found that under the condition of defective TAP function, ERGIC played a role in mediating the transport of MHC-I intracellular membrane vesicles, and this process was no longer affected by TLR signals.
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50% of patients with rheumatoid arthritis are misdiagnosed and mistreated, and multiple drugs can help achieve standard treatment
Time of Update: 2021-04-13
Starting from March 1 this year, the new JAK inhibitor drug for rheumatoid arthritis, Ailemin ( Baritinib tablets) have been successfully included in the new medical insurance for the treatment of moderate to severe active rheumatoid arthritis adult patients with poor efficacy or intolerance to one or more disease-improving anti-rheumatic drugs.
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Rheumatology: Systemic lupus erythematosus disease activity affects neurological and behavioral cognition
Time of Update: 2021-04-13
Many common factors in chronic diseases, such as fatigue and depression, affect cognitive dysfunction (CD), but the impact of systemic lupus erythematosus (SLE) disease activity on CD is unclear.
1093/rheumatology/keab256 Barraclough, Michelle et al "The effects of disease activity on neuronal and behavioural cognitive processes in systemic lupus erythematosus.
