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Nat Immunol | Zou Weiping's group reveals the mechanism of MDM2-STAT5 signaling pathway regulating T cell-mediated tumor immunity
Time of Update: 2021-04-20
Jiajia Zhou is the first author) published an article The ubiquitin ligase MDM2 sustains STAT5 stability to control T cell-mediated anti-tumor immunity in Nature Immunology, Shao Wang, University of Michigan Professor Moe is a key partner in this subject.
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How about the reduction and discontinuation of RA patients treated with hormones in the real world?
Time of Update: 2021-04-19
In response to this key issue, Professor Zhang Zhuoli’s research team based on the ten-year real-world RA treatment in the Department of Rheumatology and Immunology of Peking University First Hospital The cohort (Treat-TARget in RA, TARRA cohort), for the first time, fully revealed the dynamic trajectory and clinical characteristics of the reduction and withdrawal of hormones in RA patients under the background of csDMARDs treatment.
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ACR's latest guidelines: should rheumatism patients get the new crown vaccine?
Time of Update: 2021-04-19
Although there is a lack of direct evidence, this guideline aims to provide guidance for rheumatism healthcare providers on how to best use the COVID-19 vaccine and promote the implementation of vaccination strategies for RMD patients.
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Once blocked again, can Pfizer and Eli Lilly’s osteoarthritis painkiller Tanezumab usher in the dawn?
Time of Update: 2021-04-19
In 2004, Pfizer first submitted an investigational new drug application for Tanezumab, but it was frustrated in the Phase III clinical trial in 2010.
S. Food and Drug Administration (FDA), Pfizer reopened the Phase III clinical trial of Tanezumab.
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Faced with the threat of viruses, how can I improve my own immunity?
Time of Update: 2021-04-19
For example, during a viral infection, cholesterol synthesis is inhibited, which in turn promotes type I IFN-mediated antiviral activity through the STING-TBK1-IRF3 signaling pathway.
This study shows that serine metabolism can inhibit ATP6V0d2-mediated YAP lysosomal degradation, thereby regulating antiviral innate immunity.
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The winning weapon is within reach of the lupus erythematosus marathon line soon
Time of Update: 2021-04-19
Real-world treatment research data show that the use of belyumumab can help patients significantly reduce the amount of hormones, reduce the risk of recurrence, and delay the progression of organ damage.
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Concord experts will tell you the progress of IgG4-related diseases research!
Time of Update: 2021-04-19
Professor Zhang Wen's team used 68Ga-FAPI tracer (targeted fibroblast activation protein) to show the pathological characteristics of fibrosis of IgG4-related diseases, thereby assisting in the diagnosis of IgG4-related diseases.
Clinical diagnosis and treatment-a comprehensive understanding of IgG4 related diseases Professor Zhang Wen's team analyzed the clinical characteristics of 737 patients with IgG4 related diseases.
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How is Sjogren's syndrome diagnosed and treated?
Time of Update: 2021-04-19
Patients with pSS with renal damage have unique clinical features, high disease activity, high salivary gland biopsy positive rate, and increased inflammation, but the prevalence of dry eye is low.
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What is the relationship between IL-17A and the pain of ankylosing spondylitis?
Time of Update: 2021-04-19
In the MEASURE study, Skucilumab treatment of AS patients can quickly and lastingly relieve their low back pain, heel pain, and pain-related clinical manifestations such as morning stiffness and fatigue (Figure 2) [10-12].
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Shandong University’s Han Lihui team discovered for the first time that cGAS can be modified by arginine methylation
Time of Update: 2021-04-19
In this study, the symmetrical arginine methylation of the RGG/RG motif of cGAS by PRMT5 was defined, and its regulatory effect on the innate immune response of DNA viruses was defined.
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Significant progress has been made in drugs for allergic diseases, and sublingual immunotherapy becomes the first choice
Time of Update: 2021-04-19
This forum announced the world's first standardization for the treatment of allergic rhinitis (or conjunctivitis) caused by Artemisia annua/Mugwort pollen allergy.
Artemisia annua-sublingual immunotherapy for seasonal allergic rhinitis: A randomized controlled trial, First published: 07 February 2020 https://doi.
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Repeated fever and swollen lymph nodes, what kind of strange disease did she get?
Time of Update: 2021-04-19
Looking back at the patient’s course of disease, in fact, the onset of her MAS has long been clues: low erythrocyte sedimentation rate, intermittent decrease in white blood cells, decrease in reticulocytes, decrease in plasma fibrinogen (Fib), extremely high ferritin, severe liver damage.
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The annual event in the field of rheumatism is held, and the big coffee will show you the style of the conference!
Time of Update: 2021-04-19
*Only for medical professionals to read for reference, new drugs in the field of rheumatism and immunity emerge in endlessly and enter medical insurance, bringing greater benefits to patients. In or
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The "definition" of pulmonary hypertension has been rewritten?
Time of Update: 2021-04-19
Among them, Professor Wang Qian from the Department of Rheumatology and Immunology, Peking Union Medical College Hospital, gave a wonderful introduction to connective tissue disease pulmonary hypertension (CTD-PAH) and right heart injury, which are summarized as follows.
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This joint deformity is reversible!
Time of Update: 2021-04-18
Figure 2: A 58-year-old man with a history of systemic lupus erythematosus: finger joint deformity, hand MRI showed no articular surface erosion [3] Other systemic diseases that can be accompanied by Jaccoud arthropathy include Sjogren’s syndrome, scleroderma, Dermatomyositis, psoriatic arthritis, vasculitis, ankylosing spondylitis, mixed conjunctival tissue disease, pyoderma gangrenosum, sarcoidosis, inflammatory bowel disease and other autoimmune diseases [4].
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Cover of Science Immunology | Dr. Zhang Shengbo and others reveal the key transcription factor DC-SCRIPT for the development and function of dendritic cells
Time of Update: 2021-04-18
Michael Chopin from the WEHI Institute of the University of Melbourne published a research paper titled Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT online in Science Immunology.
Chopin, Transcriptional Networks Driving Dendritic Cell Differentiation and Function.
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What is the relationship between vasculitis and kidney damage?
Time of Update: 2021-04-18
Primary vasculitis mainly includes three types of large, medium and small vasculitis according to the size of the involved blood vessels.
In classic PAN, 63% to 76% of patients have kidney involvement, mainly renal vascular damage, visible or microscopic hematuria, moderate proteinuria, slowly progressive renal failure and hypertension.
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Lupus patients must pay attention to avoid these major medication "minefields"
Time of Update: 2021-04-18
According to the "Guidelines for Diagnosis and Treatment of Systemic Lupus Erythematosus in China 2020", the treatment principle of SLE is early and individualized treatment, which can delay disease progression to the greatest extent, reduce organ damage, and improve prognosis.
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When rheumatoid encounters Sjogren’s syndrome, how can clinical treatment achieve the "double kill" achievement? |
Time of Update: 2021-04-18
In this issue, Director Zhang Yingze of the Rheumatology Department of the China-Japan Friendship Hospital will share with us a clinical diagnosis and treatment process of patients with RA combined with SS for your reference.
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Wonderful first look!
Time of Update: 2021-04-18
In the "Guidelines for the Diagnosis and Treatment of Osteoarthritis in China", for patients with mild pain symptoms, topical NASIDs are recommended to reduce local pain in patients.
