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Arthritis Rheumatol: Type I interferon plays a key role in the development of cardiovascular disease in patients with systemic lupus erythematosus

 Last Update: 2021-04-17
 Source: Internet
 Author: User

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Neutrophil disorders and type I interferon (IFN) can cause congenital axis medsci.

medsci.

The study included patients with moderate to severe systemic lupus erythematosus who participated in phase IIb of the MUSE trial, and healthy people served as the control group.

Immune cholesterol

The analysis results showed that the formation of NET complex, tumor necrosis factor (TNF) and interleukin-10 (IL-10) levels are related to the activity of type I IFN pathway.

In summary, the results of this study support the key role of type I IFNs in regulating the vascular pathology that leads to systemic lupus erythematosus, and show that inhibiting this pathway can reduce the cardiovascular risk of patients with systemic lupus erythematosus.

Original source:

Kerry A Casey, et al.

ncbi.
nlm.
nih.
gov/32909675/" target="_blank" rel="noopener">Modulation of Cardiometabolic Disease Markers by Type I Interferon Inhibition in Systemic Lupus Erythematosus in this message

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