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Systemic lupus erythematosus (SLE) is a recurrent autoimmune disease, for which there is currently a lack of biological indicators for monitoring and predicting the occurrence of the disease.
Systemic lupus erythematosus (SLE) is a recurrent autoimmune disease, for which there is currently a lack of biological indicators for monitoring and predicting the occurrence of the disease.
Type I interferon composed of IFN-α, IFN-β, IFN-ε, IFN-κ and IFN-ω is an effective pleiotropic cytokine with diverse immune functions.
Elevated expression of ISGs is associated with the occurrence and development of SLE disease Elevated expression of ISGs is associated with the occurrence and development of SLE disease
Several gene products encoded by ISGs are related to the regulation of antiviral defense mechanisms and cell functions.
Transcriptome analysis of CD8+T and CD4+T cells in SLE patients and healthy controls
Transcriptome analysis of CD8+T and CD4+T cells in SLE patients and healthy controlsIn this study, the researchers analyzed the transcriptome of CD4+ and CD8+ T cells and found that mitochondrial-derived genes and mitochondrial-related metabolic pathways were down-regulated in patients with high IFN expression.
Changes of mitochondria of CD8+ T cells in SLE patients
Changes of mitochondria of CD8+ T cells in SLE patientsMechanism studies have shown that these "SLE-like" states will increase the consumption of NAD+ in CD8+ T cells, resulting in a decrease in mitochondrial respiratory function and a decrease in cell viability, both of which can be restored by supplementing NAD+.
Schematic diagram of type I interferon regulating SLE
Schematic diagram of type I interferon regulating SLEAll in all, the results of the study revealed that type I interferon can promote the death of CD8+ T cells through metabolic reprogramming, and promote the pathogenesis of SLE.
Type I interferon can promote the death of CD8+ T cells through metabolic reprogramming, and promote the pathogenesis of SLE.
org/10.
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