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J Dermatolog Treat: Dupilumab can effectively improve the quality of life of patients with atopic dermatitis
Time of Update: 2021-05-20
gov/31179791/" target="_blank" rel="noopener">Dupilumab improves patient-reported symptoms of atopic dermatitis, symptoms of anxiety and depression, and health-related quality of life in moderate-to-severe atopic dermatitis: analysis of pooled data from the randomized trials SOLO 1 and SOLO 2.
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Aging Cell: Why are APOE ε4 carriers at high risk of Alzheimer's disease?
Time of Update: 2021-05-20
The results showed that APOE ε4 carriers had lower average platelet mitochondrial cytochrome oxidase Vmax activity, and lymphocyte Annexin V (a marker of apoptosis) was significantly higher.
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Eur Spine J: Efficacy of golimumab in the treatment of ankylosing spondylitis-a systematic review and meta-analysis
Time of Update: 2021-05-20
gov/32447529/" target="_blank" rel="noopener">Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis .
gov/32447529/" target="_blank" rel="noopener">Patients with ankylosing spondylitis treatment by golimumab: a systematic review and meta-analysis in this message
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Nature Plants | Transcription Regulation Mechanism of Plant Early Immune Response
Time of Update: 2021-05-10
By comparing the transcriptome data of Arabidopsis thaliana processed by seven molecular patterns at different times in the early stage, this study revealed the common and specific characteristics of the early immune signal transcription response induced by different molecules, and identified new plant immune components.
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Team of Professor Zhang Zhuoli from Peking University Hospital: The real-world situation of hormone reduction in patients with rheumatoid arthritis
Time of Update: 2021-05-10
In response to this key issue, Professor Zhang Zhuoli’s research team is based on the decade-long real-world rheumatoid arthritis of the Department of Rheumatology and Immunology, Peking University First Hospital The standard treatment cohort (Treat-to-TARget in RA, TARRA cohort), for the first time, fully revealed the dynamic trajectory and clinical characteristics of the reduction and withdrawal of hormones in patients with rheumatoid arthritis in the context of csDMARDs treatment.
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After reading this popular science, it is equivalent to reviewing immunology knowledge
Time of Update: 2021-05-10
After external pathogenic microorganisms (doctors call them antigens) invade the body, if they can "pass five barriers and kill six generals" into the blood to reach the spleen and lymph nodes, T and B cells should play a role.
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How to choose medication for acute gout attacks?
Time of Update: 2021-05-10
According to the "2016 Chinese Gout Diagnosis and Treatment Guidelines", there are three types of drugs to choose from during the acute attack: colchicine, non-steroidal anti-inflammatory drugs, and glucocorticoids.
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Stones may grow on breasts and faces!
Time of Update: 2021-05-10
also reported a case of a 55-year-old man with a 35-year history of gouty arthritis (tophi on his left elbow) in the BMJ sub-Journal.
Romero AB and others reported a case of an 82-year-old man with gout associated with tophi in the elbow and metatarsophalangeal joints for 40 years.
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FDA opens a new era of mandatory enforcement of regenerative medicine therapy and stricter supervision is coming...
Time of Update: 2021-05-10
In other warning letters during the COVID-19 pandemic, the FDA also pointed out that its risk-based enforcement approach means that regenerative medicine therapies designed to prevent or treat COVID-19 are more likely to attract the attention of CBER, including intravenous or intrathecal administration.
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FDA expert group 7:2 supports the retention of Tecentriq triple-negative breast cancer...
Time of Update: 2021-05-10
In March 2019, PD-L1-positive patients' progression-free survival (PFS) results based on the IMpassion130 study of atelizumab combined with Abraxane (albumin paclitaxel) in the treatment of PD-L1-positive metastatic triple-negative breast cancer (TNBC) (7.
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Cell Highlights | XIST-mediated X chromosome inactivation participates in the regulation of immune differences between the sexes
Time of Update: 2021-05-10
By analyzing the single-cell transcriptomes of female patients with autoimmune diseases and COVID-19 infections, the authors found that XIST-dependent gene expression was excessive in CD11c + atypical B cells (ABCs), thus deducing that XIST dysregulation in these cells cannot ensure X Chromosome inactivation.
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Amgen 2021Q1: Strong growth of biosimilar drugs AMG510 approval ends...
Time of Update: 2021-05-10
Although sales of Enbrel (etanercept), an autoimmune disease treatment drug for rheumatoid arthritis, fell 20% from the first quarter of last year, it was still Amgen’s highest-revenue product, reaching US$924 million.
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How many large pharmaceutical companies’ profit revenues can’t even reach the “good value”
Time of Update: 2021-05-10
Starting from Zheng Xiaoyu's large number of drug registrations, many pharmaceutical companies have experienced the days of making money every day by taking advantage of the asymmetry of information.
Moreover, due to factors such as medical insurance control fees, pharmaceutical companies must broaden their sales platforms, such as DTP pharmacies.
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Novartis Q1: Entresto submits a substitute mine at the end of the year for US$789 million...
Time of Update: 2021-05-10
Sales in the Chinese market reached 744 million US dollars, an increase of 11%.
Novartis' current business is divided into two main lines: innovative drugs and generic drugs.
In the first quarter, net sales of innovative drugs were US$10.
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Science | Provides a new strategy for adenovirus vector vaccine design-Mucosal associated constant T (MAIT) cell activation significantly enhances the T cell response induced by adenovirus vector
Time of Update: 2021-05-10
In order to verify this conjecture, the Paul Klenerman team of the University of Oxford recently published a research paper entitled MAIT cell activation augments adenovirus vector vaccine immunogenicity on Science, and found that adenovirus vectors can activate MAIT cells to enhance the T cell response.
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The lower the uric acid, the better?
Time of Update: 2021-05-10
Director Li Fen: The national attention to gout day is set to April 20th and has its origin, because the upper limit of the normal value of uric acid for adult men is 420μmol/L.
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Results in 1 hour?
Time of Update: 2021-05-09
Under the theme of "Going International, Drawing the Future Together", Professor Hu Chaojun from Peking Union Medical College Hospital gave a wonderful interpretation of the special report on the application and development of autoantibody quantitative detection in the field of clinical rheumatism and immunology, and made a wonderful interpretation of my country's autoantibody Quantitative detection technology has made an outlook, let's take a look!
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Lung nodules appear in RA patients. Is it cancer?
Time of Update: 2021-05-09
Figure 3 A 64-year-old woman with RA: PET scan revealed increased uptake in the right upper lung lung nodules and hilar area [5] In addition to malignant tumors, when multiple cavitary pulmonary nodules appear in RA patients, the common differential diagnosis also includes granulomatous multiple Vasculitis and other autoimmune diseases, infectious diseases (bacteria such as tuberculosis, Nocardia, and aspergillosis), etc.
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The Hu Ronggui team of the Chinese Academy of Sciences reveals why most people recover from hepatitis B virus on their own
Time of Update: 2021-05-09
On April 5th, researcher Hu Ronggui from the Center for Excellence in Molecular Cell Science of the Chinese Academy of Sciences, Professor Deng Qiang from Fudan University School of Basic Medicine, Professor Zhang Jiming from Huashan Hospital of Fudan University, and Professor Xu Ping from the National Phoenix Center for Protein Science were the co-corresponding authors.
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Lupus patients have kidney and blood system involvement, but it is not because of lupus?
Time of Update: 2021-05-09
One month ago, the patient developed headache, blurred vision, nosebleeds, bleeding spots on both lower extremities, continued deterioration of renal function, decreased urine output, increased serum potassium, severe anemia, multiple serous effusions, and increased blood pressure As high as 180/130mmHg, prednisone 50mg/d is ineffective.
