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Real-world study: How should elderly patients with ITP use TPO receptor agonists?
Time of Update: 2021-11-15
Based on this, some researchers analyzed the response of ITP patients ≥60 years of age to TRA treatment, as well as the conversion of different TRA types, the risk of thrombosis/bleeding, and the patient's sustained response to treatment discontinuation (SROT) .
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An article to understand potential new treatment strategies for myelofibrosis
Time of Update: 2021-11-14
Currently, another phase III clinical trial (PACIFICA) evaluates Pacritinib and "doctor-chosen treatment" (low-dose rucotinib, hydroxyurea, danazol, or steroids) compared to patients with advanced MF and patients with severe thrombocytopenia The efficacy in .
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Long-term follow-up confirmed that Venecla and rituximab have an excellent effect in the treatment of R/R CLL patients for a fixed period of time
Time of Update: 2021-11-14
The latest research results show that the complete remission (CR) rate of veneclax combined with rituximab is 51%, the bone marrow uMRD rate is 57%, and the 2-year PFS rate is 82%; and it can be used in non-continuous treatment mode Allow patients to achieve long-lasting deep relief .
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Big coffee explores "Ao" | new hope for otuzumab cross-epoch treatment, patients with indolent lymphoma will benefit more in the future
Time of Update: 2021-11-14
New drugs led by a new generation of anti-CD20 monoclonal antibody otuzumab have shown better efficacy and safety in the treatment of indolent B-cell lymphoma, bringing more benefits to patients .
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CAR-T can reduce the risk of death in patients with refractory LBCL by 73% compared with standard salvage treatment
Time of Update: 2021-11-14
Among refractory patients who progress during the initial immunochemotherapy or within 1 year after the first remission, only 30%-40% of patients respond to salvage chemotherapy, and may subsequently receive autologous hematopoietic stem cell transplantation (ASCT) consolidation therapy .
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BJH: Therapeutic plasma exchange for severely refractory autoimmune HIT with thrombosis
Time of Update: 2021-11-12
The BJH Journal reported a case of HITT that was associated with the progression of venous thromboembolism due to flushing from exposure to unfractionated heparin (UFH), despite treatment with therapeutic fondaparinux and direct thrombin inhibitors.
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HAEMOPHILIA: Observation of pathological changes and expression of ligaments in patients with hemophilic arthritis
Time of Update: 2021-11-12
Haemophilic arthritis (HA) is the most common and serious complication in patients with hemophilia, which can lead to advanced joint dysfunction and prevention of disabilityA foreign research team conducted a study to observe the levels of lysine oxidase (LOX) and matrix metalloproteinase (MMP) -1, -2, and -3 in the ligament tissues of HA patients and osteoarthritis (OA) patients.
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Index Interpretation Test Index Clinical Interpretation (20) Platelet Test (1)
Time of Update: 2021-11-12
8. The effect of platelet aggregation increases as the concentration of sodium citrate in the plasma decreases.
In the TSP test, attention should be paid to the in vitro activation of platelets, and the smooth blood collection should be emphasized .
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HAEMATOLOGICA: TGFβ signaling alters acute immune response memory and leads to bone marrow failure
Time of Update: 2021-11-12
Qualitative, which increases the possibility that non-genetic factors are involved in the pathogenesis of the disease Therefore, in a study, a research team tested the effect of polyinosine polycytic acid (pIC) on the hematopoietic system in combination with an acute innate immune attack with an increase in the TGFβ signaling pathway in the absence of genetic mutations .
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AJH: The relationship between bidirectional disorder in adolescents and iron deficiency and fatigue symptoms without anemia
Time of Update: 2021-11-12
Phase disorders are related, and the threshold of ferritin associated with HMB fatigue in adolescents is unclear .
The study shows that iron deficiency and fatigue are very common in adolescents with bipolar disorder.
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Nat Med: How can two HIV-infected patients achieve long-term virus control after interrupting treatment?
Time of Update: 2021-11-12
In this regard, it has been shown that a small number of HIV-infected people start receiving antiretroviral therapy in the acute/early stage of infection, and the amount of virus in the plasma can be controlled for a long time after ATI (analytical treatment interruption) .
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AJH: Humoral and cellular immune responses of CLL and MBL patients to recombinant shingles vaccine
Time of Update: 2021-11-12
In summary, studies have shown that RZV does not produce cell-mediated antibody responses in MBL/CLL participants, which is comparable to age- and gender-matched antibody responses .
. RZV does not produce a cell-mediated antibody response in MBL/CLL participants, which is comparable to an age- and gender-matched antibody response .
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NEJM: Clinical features of vaccine-induced immune thrombocytopenia and thrombosis
Time of Update: 2021-11-12
Vaccine-induced immune thrombocytopenia and thrombosis formation (Vitt) is coronavirus 2 ChAdOx1nCoV-19 adenoviral vector vaccine-related syndromes emerging with one kind of severe acute respiratory syndrome .
Researchers determined the patient's baseline characteristics and clinicopathological characteristics, risk factors, treatment, and poor prognostic markers .
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AJH: Prognostic Significance of Acquired 1q22 Gain in Multiple Myeloma
Time of Update: 2021-11-12
Multiple myeloma (MM) with heterogeneous genome landscape diagnosisHere, a foreign research team described the clinical characteristics of a group of patients who gained 1q22 gains over time, and compared the risk characteristics and results compared with a matched control group .
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Index Interpretation Test Index Clinical Interpretation (18) Hemoglobin anemia
Time of Update: 2021-11-12
6 TEB buffer cellulose acetate membrane electrophoresisNormal hemoglobin electrophoresis zone: HbA>95%, HbF<2%, HbA2 is 1%~3.
Observe whether there are more red blood cells containing inclusion bodies than positive cells incubated for 10min after incubation for 2h, so as to know whether there is unstable hemoglobin such as HbH .
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Blood Cells Mol Dis: Effectiveness and safety of Eltrombopag as a second-line treatment for patients with primary immune thrombocytopenia
Time of Update: 2021-11-12
The results suggest that the total effective rate of Eltrombopag is 94% , the CR rate is 76%, and the PR is 23%; only one patient did not respond and underwent splenectomy, followed by rituximab, romiplostim and Cyclosporine treatment obtains CR .
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HAEMATOLOGICA: Ionophore-mediated osmotic swelling of red blood cells is a potential mechanism for the treatment of sickle cell disease
Time of Update: 2021-11-12
They measured the changes in cell volume and hemoglobin concentration after monensin treatment, and perfused the treated blood samples through a microfluidic device, which allowed quantitative control of blood flow under hypoxia .
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Crit Care: The effect of tranexamic acid on thrombotic events and seizures in bleeding patients
Time of Update: 2021-11-12
Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis .
1186/s13054-021- 03799-9Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis in this message
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How many milliliters of gas will cause a gas embolism?
Time of Update: 2021-11-11
How to explain gas embolism to patients?Large amounts of gas into the blood circulation within a short time or a raw gas dissolved in the blood rapidly released, forming bubbles blocking the heart vessels , we referred to as gas embolism .
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Understanding Retinol Binding Protein (RBP)
Time of Update: 2021-11-11
In-depth studies in recent years have shown that the change of RBP content can sensitively reflect the function of proximal renal tubules and the degree of liver damage, and is a sensitive indicator of the development and outcome of kidney, liver and nutritional diseases .
