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Understanding Retinol Binding Protein (RBP)

 Last Update: 2021-11-11
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Retinol binding protein ( Retinol the Binding Protein, RBP ) is synthesized in the liver cells, widely distributed in human serum, cerebrospinal fluid, urine and other body fluids

Meng Qingtao and others selected 78 patients with kidney disease as the research objects , and then selected 66 healthy people during the same period as the control group , measured the serum RBP and urine RBP levels

Liu Cheng Yuan , Yuan Yulin and so are urine RBP relationships with early renal damage were explored

RBP and kidney disease

When kidney disease occurs, due to the decline in glomerular filtration rate, renal tubule reabsorption disorder, serum and urine RBP are significantly increased

Urinary RBP and β2-MG are both proteins that reflect the function of the proximal renal tubules, but the former is highly stable in urine, difficult to decompose, and is not affected by pH and proteolytic enzymes.

RBP and liver disease RBP and liver disease

When the liver is damaged by various factors, the synthesis function of RBPis reduced, which is reflected in the decrease in the level of RBPin the blood .

At the same time, serum and urine RBP levels are helpful for the differential diagnosis of liver cirrhosis and hepatorenal syndrome: Bosinet al.

RBP and nutritional status RBP and nutritional status

Physiologically, RBPhas a short half-life and high biological specificity.

RBP and Vitamin A Deficiency RBP and Vitamin A Deficiency

Changes in serum RBP levels can sensitively reflect VitA deficiency

RBP and epidemic hemorrhagic fever RBP and epidemic hemorrhagic fever

Epidemic hemorrhagic fever is a common acute infectious disease caused by Hantavirus, and the mortality rate of severe patients is high.

Epidemic hemorrhagic fever is a common acute infectious disease caused by Hantavirus, and the mortality rate of severe patients is high.
Most patients have kidney damage, which in turn affects the level of RBP in urine .

Xuan Linhua and others dynamically monitored the level of serum retinol binding protein 4 (RBP4) and urine retinol binding protein in patients with epidemic hemorrhagic fever , and explored its clinical significance in epidemic hemorrhagic fever
.

research shows:

(1) RBP4 increased significantly from the febrile phase, and the fever, oliguria, and polyuria phases were significantly higher than those in the control group, which has clinical significance in the early diagnosis of epidemic hemorrhagic fever
.

(2) When dynamically observing the level of serum RBP4 in patients with epidemic hemorrhagic fever , BUN increased significantly while RBP4 decreased, indicating other organ damage
.

(3) Patients with epidemic hemorrhagic fever have obvious renal tubular damage when the renal function is normal in the early stage of onset
.

RBP and tumor diagnosis

RBP and tumor diagnosis RBP and tumor diagnosis

The pathological changes of the body during the development of tumor diseases and the accumulation of some chemotherapeutic drugs during the treatment process will cause varying degrees of damage to renal function, especially in patients with advanced tumors
.
Therefore, the concentration of serum RBP will fluctuate greatly
.

Scholar Cai Li [11] explored the clinical significance of Cys C and retinol-binding protein in the diagnosis of renal dysfunction in tumor patients by detecting the concentration of cystatin C (Cys C) and retinol-binding protein in the serum of tumor patients .
Which uses a latex enhanced immune nephelometry serum samples were measured in the study population CysC concentration and retinol binding protein, test results showed that serum samples of tumor patients Cys C and retinol binding protein significantly higher concentrations , two There was a statistically significant difference in comparison between the subjects (P<0.
0 5) .
At the same time , the positive detection rates of serum CysC and retinol binding protein in tumor patients were both about 65.
0% .
It shows that the detection of serum CysC and retinol-binding protein concentration can be preferentially used as a detection index to diagnose the degree of renal damage in tumor patients , and the changes in their concentration are of great significance to the monitoring of renal damage in tumor patients .

The scholar Cai Li [11] explored the clinical significance of Cys C and retinol-binding protein in the diagnosis of renal dysfunction in tumor patients by detecting the concentration of cystatin C (Cys C) and retinol-binding protein in the serum of tumor patients .
Which uses a latex enhanced immune nephelometry serum samples were measured in the study population of immune CysC and retinol binding protein concentration, the detection results showed that serum samples of tumor patients Cys C and retinol binding protein concentration was significantly higher , The difference between the two was statistically significant (P<0.
0 5) .
At the same time , the positive detection rates of serum CysC and retinol binding protein in tumor patients were both about 65.
0% .
It shows that the detection of serum CysC and retinol-binding protein concentration can be preferentially used as a detection index to diagnose the degree of renal damage in tumor patients , and the changes in their concentration are of great significance to the monitoring of renal damage in tumor patients .

Therefore, as a sensitive detection index , RBP is not only widely used in the early diagnosis and curative effect observation of kidney disease, but also in the diagnosis of human liver function, clinical nutritional status, vitamin A deficiency, epidemic hemorrhagic fever, tumor diagnosis, etc.
The diagnosis has high clinical significance and is worthy of our extensive clinical use
.

Some references:

.
1 , Smith FR, et Al of The Effects of The s disease of liver, The Thyroid ON Transport and Kidneys of Vitamin A in Human Plasma J Clin Invest 1971; 25:.
.
2426.

.
1 , Smith FR, et Al of The Effects of s disease of The liver, Thyroid and Kidneys ON The Transport of Vitamin A in Human Plasma J Clin Invest 1971; 25:.
.
.
2426 .
1 , .
Smith FR, et Al of The Effects of s disease of the liver, thyroid and kidneys on the transport of vitamin A in human plasma.
J Clin Invest 1971; 25:2426.

2 , .
Bosin E, Monji N.
the Analysis of serum and urinary Retinol-Binding Protein in Hepato-Renal syndrome Clin Biochem 1987; 20:47.

2 , .
Bosin E, Monji N.
the Analysis of serum and urinary Retinol-Binding Protein in Hepato-Renal syndrome Clin Biochem 1987;.
20:47 2 , Bosin E, Monji N.
the Analysis of serum and urinary Retinol-Binding Protein in Hepato -Renal syndrome.
Clin Biochem 1987; 20:47.

.
3 , Winkler the MF, et Al the Use of Retinol Binding Protein and prealbumin AS-Indicators of Response to Therapy Nutrition J Am Diet Assoc 1989; 89:.
.
684.

.
3 , Winkler the MF, et Al the Use of Retinol-Binding Protein and prealbumin AS Indicators of Response to Nutrition Therapy J Am Diet Assoc 1989; 89:.
.
.
684 .
3 , Winkler the MF, et Al the Use of Retinol-Binding Protein and prealbumin.
as indicators of response to nutrition therapy.
J Am Diet Assoc 1989; 89:684.

4.
Deng Rongchun, Shi Qiaofa.
Progress in clinical application of retinol binding protein [J] .
Experimental and Laboratory Medicine, 2012 , 30 (1): 41-43 .

4.
Deng Rongchun, Shi Qiaofa.
Progress in clinical application of retinol binding protein [J] .
Experimental and Laboratory Medicine, 2012 , 30 (1): 41-43 .
4.
Deng Rongchun, Shi Qiaofa.
Progress in clinical application of retinol binding protein [J] .
Experimental and Laboratory Medicine, 2012 , 30 (1): 41-43 .

5 , of management of Zhang Yu, Chen vigorously.
To explore the clinical application of serum retinol binding protein detection in renal diseases [J] .
Chinese Journal of Health Inspection, 2010 , 11 (20): 2908-2909 .
5 , of management of Zhang Yu, Chen vigorously.
To explore the clinical application of serum retinol binding protein detection in renal diseases [J] .
Chinese Journal of Health Inspection, 2010 , 11 (20): 2908-2909 .

6 , Liu Cheng Yuan, Liu Jing, Liu Ning, and so on.
The value of detection of urine microalbumin and retinol binding protein in the diagnosis of diabetic nephropathy [J] .
Labeled Immunoassay and Clinic, 2010 , 12 (17): 361-363 .
6 , Liu Cheng Yuan, Liu Jing, Liu Ning, and so on.
The value of detection of urine microalbumin and retinol binding protein in the diagnosis of diabetic nephropathy [J] .
Labeled Immunoassay and Clinic, 2010 , 12 (17):361-363 .

7.
Yuan Yulin, Liu Jing, Liu Ning, etc.
Random urine and morning urine retinol binding protein in the diagnosis of early renal damage [J] .
Advances in Modern Biomedicine, 2013 , 13 (16): 3135-3139 .

7.
Yuan Yulin, Liu Jing, Liu Ning, etc.
Random urine and morning urine retinol binding protein in the diagnosis of early renal damage [J] .
Advances in Modern Biomedicine, 2013 , 13 (16): 3135-3139 .
7.
Yuan Yulin, Liu Jing, Liu Ning, etc.
Random urine and morning urine retinol binding protein in the diagnosis of early renal damage [J] .
Advances in Modern Biomedicine, 2013 , 13 (16): 3135-3139 .

8 , Zhang stars, Wu Jian, Xu and other arts.
Correlation analysis between serum retinol binding protein level and Child-Pugh classification of liver cirrhosis [J] .
Chinese Journal of Modern Medicine, 2014 , 8 (16): 17-19 .
8 , Zhang stars, Wu Jian, Xu and other arts.
Correlation analysis between serum retinol binding protein level and Child-Pugh classification of liver cirrhosis [J] .
Chinese Journal of Modern Medicine, 2014 , 8 (16): 17-19 .

9.
Chen Huanwei, Zhen Zuojun, Pan Wensong.
The significance of prealbumin and retinol-binding protein in the assessment of parenteral nutrition [J] .
Parenteral and Enteral Nutrition, 2001 , 8 (3): 149-150 .
9.
Chen Huanwei, Zhen Zuojun, Pan Wensong.
The significance of prealbumin and retinol-binding protein in the assessment of parenteral nutrition [J] .
Parenteral and Enteral Nutrition, 2001 , 8 (3): 149-150 .

10.
Xuan Linhua, Han Xueji.
The clinical significance of blood and urine retinol binding protein detection in epidemic hemorrhagic fever [J] .
Modern Preventive Medicine, 2013 , 40 (3): 536-540 .

10.
Xuan Linhua, Han Xueji.
The clinical significance of blood and urine retinol binding protein detection in epidemic hemorrhagic fever [J] .
Modern Preventive Medicine, 2013 , 40 (3): 536-540 .
10.
Xuan Linhua, Han Xueji.
The clinical significance of blood and urine retinol binding protein detection in epidemic hemorrhagic fever [J] .
Modern Preventive Medicine, Prevention 2013 , 40 (3): 536-540 .

11.
Cai Li.
The value of detection of serum peptostatin C and retinol binding protein in tumor diagnosis [J] .
Laboratory Medicine and Clinics, 2013 , 9(10): 2405-2406 .

11.
Cai Li.
The value of detection of serum peptostatin C and retinol binding protein in tumor diagnosis [J] .
Laboratory Medicine and Clinics, 2013 , 9(10): 2405-2406 .
11.
Cai Li.
The value of detection of serum peptostatin C and retinol binding protein in tumor diagnosis [J] .
Laboratory Medicine and Clinics, 2013 , 9(10): 2405-2406 .

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