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Hepatology: Differences in clinical features and prognosis between intrahepatic cholangiocarcinoma and hepatocellular carcinoma!
Time of Update: 2021-06-21
In the subgroup analysis, the OS of iCCA patients with poor prognostic factors was better than that of HCC patients with the same adverse prognostic factorsIn summary, the study revealed demographic, socioeconomic, and clinical characteristics related to the diagnosis of iCCA in patients with primary liver cancer .
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Nat Commun: WSX1: A new tumor suppressor for hepatocellular carcinoma
Time of Update: 2021-06-21
Related diagramsRelated diagramsAll in all, the results of the study revealed that WSX1 is a tumor suppressor, which can enhance the immune surveillance of the liver by blocking the PI3Kδ/AKT/GSK3β/PD-L1 pathway .
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Lancet Oncol: Stereotactic radiotherapy can more effectively relieve the pain of patients with spinal metastases than conventional external radiotherapy
Time of Update: 2021-06-21
Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial .
1016/S1470-2045(21)00196-0Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial in this message
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JAMA Netw Open: Cancer screening can reduce all-cause mortality, but it still needs to be individualized!
Time of Update: 2021-06-21
Researchers Cox estimation model 10 years, all-cause mortality and acceptance of breast X -rays or prostate-specific antigen ( PSA relationship between the) examination, and tested for potential confounding factors between cancer mortality and screening, namely education , income, marital status, geographic area, cognition, self-reported health, self-care and self-perception and so on .
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Br J Cancer: Regulatory T cells can predict the clinical outcome of patients with soft tissue sarcoma
Time of Update: 2021-06-21
The prognostic impact of this study is to analyze tumor infiltrating lymphocytes (TIL) and immune checkpoint markers in STS, and to evaluate its local recurrence (LR), distant metastasis (DM) and overall survival (OS) of the disease.
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[Tiantan Hospital Liu Baiyun live broadcast preview] On June 15th, 18:30 pm, clinical treatment and imaging diagnosis of craniocerebral trauma
Time of Update: 2021-06-21
At 19:00 on June 15, Capital Medical University, Beijing Tiantan Hospital ward director [ Liu Bai Yun ] professors teach online, scan code free registration, live on-site pumping paper books!Liu Baiyun, Director of Ward, Beijing Tiantan Hospital, Capital Medical University Clinical treatment and imaging diagnosis of craniocerebral traumaTraumatic brain injury clinical treatment and imaging diagnosis diagnosis Craniocerebral trauma is a common disease in neurosurgery.
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Nat Commun: Bi-drug antibody-drug conjugate: a weapon against the heterogeneity and resistance of breast cancer
Time of Update: 2021-06-21
In a xenograft mouse model that exhibits intratumoral HER2 heterogeneity and increased drug resistance, dual-drug ADCs have greater therapeutic effects and survival benefits than the combined use of two single-drug variants .
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The latest impact factor forecast 3: Are the four favorite water journals of Chinese researchers really water?
Time of Update: 2021-06-21
The forecasting method we use today is still the traditional forecast based on the document type (Article & Review) and time window (2018-2019) stipulated by the JCR (the calculation result time is as of June 10, 2021), but because it has not been obtained The data is published online, so our data may be different from the impact factor data of the JCR report published this year .
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Clin Cancer Res: Zotiraciclib combined with temozolomide in the treatment of recurrent high-grade astrocytoma
Time of Update: 2021-06-21
The toxicity characteristics of Zotiraciclib combined with temozolomide for recurrent high-grade astrocytoma and the determination of the best dosing regimenThis is a two-stage phase I trial that uses Bayesian optimal interval design to determine the maximum tolerated dose (MTD) of Zotiraciclib and dose-intensive (Arm1) or rhythmic (Arm2) temozolomide; then expand at random The cohort compared the progression-free survival rate (PFS4) of the two groups at 4 months .
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Blood: The prognosis of patients with mantle cell lymphoma with positive LRPAP1 autoantibodies is relatively good!
Time of Update: 2021-06-21
It is associated with a higher 5-year treatment failure-free survival rate (FFS) and a higher 5-year treatment failure-free survival rate (FFS) is associated with an excellent overall survival rate ( OS) correlates with excellent overall survival (OS)The results of this study show that the clinical treatment results of patients with LRPAP1 autoantibody seropositive are better, and LRPAP1 autoantibodies may be used as a prognostic indicator for patients with mantle cell lymphoma .
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Br J Cancer: The prognostic and diagnostic significance of neutrophil lymphocyte ratio NLR in hepatocellular carcinoma
Time of Update: 2021-06-21
NLR is a hypothetical indicator that measures the balance between neutrophil-related tumor-promoting inflammatory response and lymphocyte-dependent anti-tumor immune function, and has been considered as a prognostic factor for many cancers including HCC .
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Cancers: The clinical relevance of circulating tumor cells (CTCs) to patients with metastatic colorectal cancer: a prospective COLOSPOT study
Time of Update: 2021-06-21
Therefore, the research team from France constructed the CK19-EPISPOT assay and carried out a prospective study COLOSPOT, mainly using the CK19-EPISPOT assay and CellSearch ®system to detect CTCs, and to evaluate the application of FOLFIRI-bevacizumab to CTCs The prognostic value of treated patients with metastatic colorectal cancer .
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Br J Cancer: berzosertib + gemcitabine + cisplatin combined treatment of advanced solid tumors
Time of Update: 2021-06-21
The researchers used a standard 3+3 dose escalation treatment strategy to evaluate the safety, tolerability, pharmacokinetics (PK) and preliminary efficacy of intravenous berzosertib + gemcitabine + cisplatin combination therapy .
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Ann Oncol: Efficacy and safety of pembrolizumab combined with pemetrexed + platinum in the treatment of patients with metastatic non-squamous non-small cell lung cancer: KEYNOTE-189
Time of Update: 2021-06-21
To evaluate the efficacy and safety of pembrolizumab combined with pemetrexed + platinum in the first-line treatment of patients with metastatic non-squamous non-small cell lung cancer compared with placebo combined with pemetrexed + platinum .
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Nat Commun: UV radiation induces the degradation of collagen and inhibits the invasion of melanoma
Time of Update: 2021-06-21
In this study, the researchers aimed to explore how UVR affects the function of skin fibroblasts, the extracellular matrix (ECM), and the infiltration of melanoma .
The infiltration of primary melanoma on the skin with collagen degradation is reduced, and the survival rate of patients can be improved .
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AHA: Walking may significantly reduce all-cause mortality, only 4,500 steps per day!
Time of Update: 2021-06-21
Compared with women who do not walk, the number of accidental steps per day increases by 1,000 steps, and the all-cause mortality rate is reduced by about 28% .
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JAMA Netw Open: Carotenoids may reduce all-cause mortality
Time of Update: 2021-06-21
Recently, a study published in the journal JAMA Netw Open showed that in an analysis using repeated measures, higher levels of serum carotenoids and 25- year follow-up period all-cause and specific cause death risks were statistically significantly reduced Related .
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Ann Surg: Is esophageal cancer resection, thoracotomy or transthoracoscope?
Time of Update: 2021-06-21
The survival outcome of patients with esophageal squamous cell carcinoma (ESCC) treated with thoracotomy or thoracoscopic esophagectomy is unclearThis study aimed to compare the overall survival prognosis of ESCC patients who did not receive neoadjuvant CRT treated with thoracotomy or thoracoscopic esophagectomy .
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JCO: The incidence of ALK genetic variants in high-risk neuroblastoma and its impact on prognosis
Time of Update: 2021-06-21
In summary, for patients with high-risk neuroblastoma, ALK genetic variation (clonal mutation or amplification) is an independent predictor of poor survival prognosis .
For patients with high-risk neuroblastoma, ALK genetic variation (clonal mutation or amplification) is an independent predictor of poor survival prognosis.
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The first in China!
Time of Update: 2021-06-20
On June 7, the new drug clinical trial application (IND) of the antibody-conjugated drug MRG004A that targets tissue factor (TF) submitted by Shanghai Miac, a wholly-owned subsidiary of Lepu Bio, was accepted by CDE .
