JAMA Netw Open: Carotenoids may reduce all-cause mortality

A number of studies have found that eating vegetables and fruits through diet can help reduce overall and specific cause mortality
.

The protective effect of vegetables and fruits may be attributed to the carotenoids contained in them.

A number of studies have found that eating vegetables and fruits through diet can help reduce overall and specific cause mortality

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Although a large number of prospective studies have shown that serum carotenoid levels are associated with all-cause mortality, most studies have not considered the health effects of long-term changes in serum carotenoid levels
.

Recently, a study published in the journal JAMA Netw Open showed that in an analysis using repeated measures, higher levels of serum carotenoids and 25- year follow-up period all-cause and specific cause death risks were statistically significantly reduced Related

Although there are a large number of prospective studies showing that serum carotenoid levels are related to all-cause mortality, most studies have not considered the impact of long-term changes in serum carotenoid levels on health

In this study, researchers collected 1990 years to 1999 physical examination of the information and follow-up of eligible participants to 2017 years 12 months, the median follow-up period was 22.
3 years
.

The baseline data of the included individuals were 40 years of age or older, who were residents of the research site in Yakumo Town, Hokkaido, Japan, and participated in at least one physical examination from 1990 to 1999 , and 3116 participants were finally included .

In this study, researchers collected 1990 years to 1999 physical examination of the information and follow-up of eligible participants to 2017 years 12 months, the median follow-up period was 22.
3 years

Research design

Research design

According to "International Classification of Diseases," and the ninth edition of "International Classification of Diseases and Related Health Problems statistical classification of" the tenth edition of the code classification, records of all-cause, cancer, and heart vascular mortality of the disease
.

By Cox regression model to check the time varying between serum carotenoid levels and mortality associated

According to "International Classification of Diseases," and the ninth edition of "International Classification of Diseases and Related Health Problems statistical classification of" the tenth edition of the code classification, records of all-cause, cancer, and heart vascular mortality of the disease

The results showed that among the 3116 participants who underwent the physical examination , the average age was 54.

The relationship between the level of total carotenoids in serum and all-cause mortality

The relationship between the level of total carotenoids in serum and all-cause mortality

In addition, when measuring only the baseline , for every 25% increase in serum total carotenoid levels , all-cause mortality ( HR , 0.
92 ; 95% CI , 0.
89-0.
95 ; P <.
001 ), cancer mortality ( HR , 0.
87 ; 95% CI , 0.
83-0.
93 ; P <.
001 ) and cardiovascular disease mortality ( HR , 0.
93 ; 95% CI , 0.
88-0.
99 ; P = .
03 ) risk is also significantly reduced, but with repeated measurement of HR The value is larger .

In addition, when only the baseline measurement, the serum total carotenoid level increases every time the serum total carotenoid level increases by 25%
when only the baseline measurement is performed , the all-cause mortality rate ( HR , 0.

92 ; 95% CI , 0.
89-0.

In summary, this study found that in the analysis using repeated measurements, the higher serum carotenoid levels and the higher serum carotenoid levels in the analysis using repeated measurements were associated with the 25- year follow-up period.
The mortality rate of specific causes is significantly reduced

Original source

Ryosuke Fujii, PhD ¹ ;  Yoshiki Tsuboi, MHSc ¹ ;  Keisuke Maeda, PhD ¹ ;  et al.

Ryosuke Fujii, PhD ^{1 1 1} ;  Yoshiki Tsuboi, MHSc ¹ ;  Keisuke Maeda, PhD ¹ ;  Yoshiki Tsuboi, MHSc ^{1 1} Keisuke Maeda, PhD ^{1 1} et al.
Analysis of Repeated Measurements of Serum Carotenoid Levels and All-Cause and Cause- Mortality in Japan Specific .
the Analysis of Carotenoid the Repeated Measurements Serum Levels of All and the Cause-and-Specific the Cause Mortality in Japan JAMA the Open Netw.
.
  2021;.
4 (.
6):.
e2113369 DOI: 10.
1001 / jamanetworkopen.
2021.
13369 .
Netw.
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