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Cancers: The clinical relevance of circulating tumor cells (CTCs) to patients with metastatic colorectal cancer: a prospective COLOSPOT study

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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Colorectal cancer (CRC) is one of the malignant tumors with high morbidity and mortality
.

For metastatic CRC, currently commonly used first-line treatment drugs include targeted drugs (bevacizumab/cetuximab) combined with chemotherapy (oxaliplatin, irinotecan, fluorouracil, xeloda, etc.

Colorectal cancer (CRC) is one of the malignant tumors with high morbidity and mortality

The study was carried out in 11 research centers in France, and patients were treated with FIOLFIRI-bevacizumab
.

The EPISPOT assay was used to detect CTCs at baseline (D 0 ), day 14 (D 14 ), day 28 (D 28 ), day 42 (D 42) and day 56 (D 56 ); while CellSearch ® system was used CTCs were detected at the patient's baseline (D 0 ), and on the 28th day (D 28 )

The study was carried out in 11 research centers in France, and patients were treated with FIOLFIRI-bevacizumab

According to EPISPOT assay, at D 0, 32/152 (21%) patients had ≥1 CTC/sample and 18/152 had ≥2 CTCs/sample (11.

EPISPOT assay showed that on D28, patients with ≥2 CTCs had worse PFS and OS than patients with <2 CTCs, and there was a statistical difference (median PFS = 5.

PFS and OS grouped by two detection methods at D28

Divide the results of D0 and D28 into two groups: (1) D0 and D28 are both positive for CTC (2) D0 and D28 are both negative, or only D0 or D28 are positive
.

EPISPOT assay showed that the PFS and OS of patients in group 1 were worse (median PFS = 7.

Divide the results of D0 and D28 into two groups: (1) D0 and D28 are both positive for CTC (2) D0 and D28 are both negative, or only D0 or D28 are positive

PFS and OS grouped by two detection methods at D0-D28

Univariate analysis, early CTC dynamics (two detection methods), ECOG PS at D0, and BRAF mutation status are predictors of PFS and OS
.

The primary tumor of the right colon was also significantly associated with poor OS

Univariate analysis, early CTC dynamics (two detection methods), ECOG PS at D0, and BRAF mutation status are predictors of PFS and OS

Multivariate analysis of PFS and OS related factors

In summary, D28 and D0-D28 circulating tumor cells (CTCs) are related to the prognosis of patients with colorectal cancer, and can be used to monitor the efficacy of FOLFIRI-bevacizumab therapy
.

The detection of D28 and D0-D28 circulating tumor cells (CTCs) is related to the prognosis of patients with colorectal cancer and can be used to monitor the efficacy of FOLFIRI-bevacizumab therapy

Original source:

Mazard, T.
; Cayrefourcq, L.
; Perriard, F.
; et al.
Clinical Relevance of Viable Circulating Tumor Cells in Patients with Metastatic Colorectal Cancer: The COLOSPOT Prospective Study.
Cancers 2021, 13, 2966.
https://doi.
org/10.
3390/cancers13122966.

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