JAMA Netw Open: Cancer screening can reduce all-cause mortality, but it still needs to be individualized!

Cancer screening is an important way to detect cancer and precancerous lesions early, but it is not immediate.
It has been proven that cancer screening has a lag of about 10 years
.

An increasing number of studies and clinical practice guidelines suggest that cancer screening should take into account the life expectancy of patients, and patients with limited life expectancy may suffer short-term harm from screening

Cancer screening is an important way to detect cancer and precancerous lesions early, but it is not immediate.

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A previous study showed that receiving cancer screening itself is independently associated with 10- year mortality
.

The guidelines recommend againstroutine breast and prostate cancer screening for elderly people whose

A previous study showed that receiving cancer screening itself is independently associated with 10- year mortality

Researchers Cox estimation model 10 years, all-cause mortality and acceptance of breast X -rays or prostate-specific antigen ( PSA relationship between the) examination, and tested for potential confounding factors between cancer mortality and screening, namely education , income, marital status, geographic area, cognition, self-reported health, self-care and self-perception and so on
.

Researchers Cox estimation model 10 years, all-cause mortality and acceptance of breast X -rays or prostate-specific antigen ( PSA relationship between the) examination, and tested for potential confounding factors between cancer mortality and screening, namely education , income, marital status, geographic area, cognition, self-reported health, self-care and self-perception and so on
.

The results showed that the breast cancer screening cohort included 3257 women with an average age of 77.

8 years, and the prostate cancer screening cohort included 2085 men with an average age of 76.
1 years

The results showed that the breast cancer screening cohort included 3257 women with an average age of 77.

The relationship between 10-year follow-up cancer screening and all-cause mortality.

The relationship between 10-year follow-up cancer screening and all-cause mortality.

In addition to cognitive factors, all potential confounders not weaken the association between screening and mortality, cognitive factors breast X -ray examination of aHR from 0.
67 ( 95% CI , 0.
60-0.
74 weakened) to 0.
73 ( 95 %CI , 0.
64-0.
82 ), the aHR of PSA was weakened from 0.
88 ( 95%CI , 0.
78-0.
99 ) to 0.
92 ( 95%CI , 0.
80-1.
05 ), making PSA screening no longer statistically significant
.

In addition to cognitive factors, all potential confounders not weaken the association between screening and mortality, cognitive factors breast X -ray examination of aHR from 0.
67 ( 95% CI , 0.
60-0.
74 weakened) to 0.
73 ( 95 %CI , 0.
64-0.
82 ), the aHR of PSA was weakened from 0.
88 ( 95%CI , 0.
78-0.
99 ) to 0.
92 ( 95%CI , 0.
80-1.
05 ), making PSA screening no longer statistically significant
.

In addition to cognitive factors, all potential confounders not weaken the association between screening and mortality, cognitive factors breast X -ray examination of aHR from 0.

Association of all-cause mortality between potential confounding factors and cancer screening.

Association of all-cause mortality between potential confounding factors and cancer screening.

In addition, the researchers emphasized that existing cancer screening algorithms for life prediction, including claims-based algorithms and self-reported comorbidities and functions based algorithms, may underestimate the life expectancy of patients who are subsequently screened for cancer
.

Moreover, in the specific context of cancer screening, using 10- year life expectancy as the only factor in routine screening may be too simplistic.

In addition, the researchers emphasized that existing cancer screening algorithms for life prediction, including claims-based algorithms and self-reported comorbidities and functions based algorithms, may underestimate the life expectancy of patients who are subsequently screened for cancer

In conclusion, in this cohort study, the researchers found that after taking into account age, comorbidities and functional status, receiving breast or prostate cancer screening is associated with a reduction in all-cause mortality

Original source

Nancy L.
Schoenborn, MD, MHS1,2;  Orla C.
Sheehan, MBBCh, PhD1,2 ;  David L.
Roth, PhD1,2 ; et al.
Association Between Receipt of Cancer Screening and All-Cause Mortality in Older Adults.
JAMA Netw Open.
2021;4(6):e2112062.
doi:10.
1001/jamanetworkopen.
2021.
12062

Nancy L.
Schoenborn, MD, MHS1,2;  Orla C.
Sheehan, MBBCh, PhD1,2 ;  David L.
Roth, PhD1,2 ; et al.
Association Between Receipt of Cancer Screening and All-Cause Mortality in Older Adults.
JAMA Netw Open.
2021;4(6):e2112062.
doi:10.
1001/jamanetworkopen.
2021.
12062 Orla C.
Sheehan, MBBCh, PhD1,2 David L.
Roth, PhD1,2 Association Between Receipt of Cancer Screening and All-Cause Mortality in Older Adults.
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