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Hepatology: Differences in clinical features and prognosis between intrahepatic cholangiocarcinoma and hepatocellular carcinoma!

 Last Update: 2021-06-21
 Source: Internet
 Author: User

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Intrahepatic cholangiocarcinoma (iCCA) and hepatocellular carcinoma (HCC) are the most common primary liver cancers
.

However, the clinical features and clinical prognosis of these two liver cancers have not been studied on a large scale

This study aims to investigate the clinical characteristics and clinical prognosis differences between iCCA and HCC through large sample analysis

Researchers extracted demographic and clinical characteristics of HCC and iCCA patients from 18 databases (2000-2017)
.

Logistic regression analysis was used to determine factors related to iCCA diagnosis and HCC

diagnosis

A total of 13611 iCCA patients and 96151 HCC patients were enrolled
.

Half of iCCA patients (50.

Compared with HCC, age (<50 years or ≥65 years), female, non-Hispanic white, higher income, rural areas, and higher tumor burden are all independently associated with iCCA diagnosis

Comparison of overall survival of patients with iCCA and HCC

The OS of iCCA patients was shorter than that of HCC patients (9 vs 13 months; p<0.
001)
.

However, in the multivariate analysis, the OS of patients with iCCA and HCC was comparable (adjusted hazard ratio [aHR] 1.

The OS of iCCA patients was shorter than that of HCC patients (9 vs 13 months; p<0.

For the subgroup with poor prognostic risk factors, the OS of iCCA patients is longer than that of HCC patients.

Original source:

Lee Yi-Te,Wang Jasmine J,Luu Michael et al.

Comparison of Clinical Features and Outcomes between Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma in the United States in this message

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