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The study found gender specificity in Alzheimer's therapy
Time of Update: 2021-03-04
many drug candidates may have different effects between different genders, we need to be extra cautious in our future clinical trial designs," said Abdelrahman, a research institute.
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Nature interpretation! Scientists reveal the immune drivers that induce the body's brain to age!
Time of Update: 2021-03-04
Photo Source: Blocking specific interactions with a large number of subjects present in bone marrow cells may be enough to restore young metabolism and function in mice and human bone marrow cells, a blocking process that can also reverse age-related intellectual regression in older mice and restore their brain recall and navigation to the levels shown in younger mice, according to effective blocking researchers.
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The study found that oxytocin regulates human decoding of chemical sex cues
Time of Update: 2021-03-04
the study found that oxytocin, rather than pressurized, modulates the decoding of female information carried by heterosexual men to female terpenes and the decoding of male information carried by gay men to male steroids, a common antagonist Atosiban that blocks individuals' decoding of chemical sex cues.
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JCI insight: Early link between key proteins and Alzheimer's disease
Time of Update: 2021-03-04
the results of this study showed that an increase in the amount of tau protein in the brain, its main aggregation site, was particularly associated with an increase in cortical excitability levels, while the researchers did not observe a significant relationship between the β-amyloid protein content in the upper cortical layer.
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Nature: Study reveals blood pressure control mechanism after spinal injury
Time of Update: 2021-03-04
"The spinal cord is like a communication line that allows the brain to send signals to the body, such as when and how to move and how to control important functions, including blood pressure," said Phillips, lead researcher and assistant professor at CSM.
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Neuron: Stimulating brain path paths shows the origins of human language and memory
Time of Update: 2021-03-04
study, published in the journal Neuron, a team led by the University of Newcastle and the University of Iowa compared auditory cortical information from humans and primates and found strong connections.
experts also compared the results of stimulating the auditory cortical layer and visualizing important areas of monkey language and memory.
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Cell Rep: Painkillers can be used to repair spinal injuries
Time of Update: 2021-03-04
January 27, 2021 // -- A study led by Ohio State University's Wexner Medical Center and School of Medicine found that the widely used painkiller gabapentin can prevent harmful structural changes in the spinal cord in mice and prevent immunosuppression caused by cardiovascular changes and spinal cord injuries.
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JAMA neurology: The efficacy of Atabecestat in the treatment of preclinical Alzheimer's disease
Time of Update: 2021-03-03
To that end, the team, led by researchers at Harvard Medical School's Bregan Women's Hospital, conducted a truncated randomized Phase 2b/3 clinical trial of attabes' treatment of PCAD efficacy, safety, biomarker effects, and potential cognitive and behavioral recovery.
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JAMA: Study of long-term stroke risk after a short-term isoemia attack
Time of Update: 2021-03-03
the main endpoints of the study were TIA incidence in the general population, the incidence of short-term strokes (7 days, 30 days and 90 days) after the first TIA, and the incidence of long-term stroke (greater than 1-10 years), compared to stroke patients without TIA history.
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JNNP: A computerized predictive model for the restoration of upper limb function in stroke patients
Time of Update: 2021-03-03
In the current study, it was used to assess the recovery of upper limb capacity in the first six months after a stroke, which is measured by the ARAT score to complete lateral tasks such as picking up a cup, moving objects, and manipulating small objects.
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Nat Commun: GD2-B7H3 SynNotch CAR-T preclinical evaluation in metastasis neuroblastoma
Time of Update: 2021-03-03
the current ability to use preclinical models to predict clinical toxicity of chisellular antigen-infested (CAR) T cells in solid tumors is weak, so we need to develop and evaluate gate-controlled systems.
, human B7H3 CAR-T cells showed efficacy in preclinical models of neuroblastoma.
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How do social media and lack of sleep affect our emotions?
Time of Update: 2021-03-03
, using social media for more than two hours before going to bed at night can make our sleep quality worse, which in turn can lead to anxiety, depression and other negative emotions.
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Acta Neuropathologica: MS selective neurodegenerative changes may be secondary to cortique demyelination
Time of Update: 2021-03-03
above, this selective neurodegenerative change observed in rodent models and human MS may be secondary to cortial demyelination, mainly through the loss of intermediate neurons, axons, and synapses.
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29, 2021 in the journal Science
Time of Update: 2021-03-03
.2.ScienceDaily Inhibition of 15-PGDH protein allows older mice's muscles to return to old children doi:10.1126/science.abc8059; Doi:10.1126/science.abf9566 In a new study, researchers from Stanford University School of Medicine in the United States found that blocking the activity of a protein in older mice for a month restores the mass and strength of their atrophy muscles and helps them run longer on treadmills.
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Research reveals the mechanisms of genomic regulation in the evolution of the human brain
Time of Update: 2021-03-03
Combining multi-group mapping data from these macaque fetal brains, the researchers for the first time constructed fine spatial images of chromatin in the development of the macaque fetal brain, identifying chromatin structures at different scales, including chromatin region chambers, chromatin topology domains (TADs) and chromatin rings (Loops), as well as regulatory elements (e.g. enhancers, initiations, etc.) that play an important role in brain development.
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New drug for epilepsy! EU CHMP recommends approval of Xcopri (cenobamate): complementary treatment of adult eclampsia epilepsy!
Time of Update: 2021-03-02
recently, the company announced that the European Medicines Agency (EMA) Human Pharmaceutical Products Committee (CHMP) has issued an active review recommending the approval of Xcopri (cenobamate), an anti-epileptic drug (AED) for adult patients with epilepsy who have previously been treated with at least two anti-epileptic drugs (ASM) but have not been adequately controlled, to assist in the treatment of developed seizures (accompanied or not accompanied by systemic seizures).
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An inventory of the latest advances in aging research
Time of Update: 2021-03-02
doi:10.1038/s41586-020-03160-0 Scientists from Institutions such as Stanford University Medical Center have revealed the immune drivers that induce brain aging in a recent study published in the international journal Nature entitled "Restoring metabolism of myeloid cells reverses decline in the ageing".
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Highlights of the Study that Cell Journal had to look at in January 2021
Time of Update: 2021-03-02
The new study reveals that in addition to being a gene editing tool, CRISPR/Cas9 could also act as a regulator switch to regulate gene activity doi:10.1016/j.cell.2020.12.017 In a series of experiments on laboratory-cultured bacteria, researchers from Johns Hopkins University in the United States have found evidence that the widely used gene cutting system CRISPR-Cas9 also has another effect--- its role in lowering or weakening CRISPR-Cas9 activity may help scientists develop new methods of cell genetic engineering for research purposes.
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Sci Rep: What's new! Anxiety disorders occur or are associated with the body's gut microbiome!
Time of Update: 2021-02-28
Then the researchers conducted a genome-wide association study (GWAS) analysis, comparing mice with high levels of anxiety and low levels of anxiety, and analyzing and comparing differences in the gut microbiomes of two groups of mice, and then identified special genetic mutations and intestinal microbiome families associated with anxiety-like behavior, including some special host genes, which indirectly affect the performance of body anxiety by regulating the abundance of specific microorganisms in the gut.
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Sci Transl Med: Scientists hope to use a new smartphone to help monitor the progression of Parkinson's disease
Time of Update: 2021-02-28
9, 2021 // -- In a study published in the international journal Science Translational Medicine, Apple Inc. and several research institutions in the United States have jointly developed a smartwatch that may provide valuable resources to help track the progress of disease in people with Parkinson's disease.
