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JCEM: Clinical Observation of Teriparatide in the Treatment of Premenopausal Idiopathic Osteoporosis
Time of Update: 2022-01-08
TBS will also increase in premenopausal idiopathic osteoporosis women who have completed 12 months and 24 months of denosumab treatment.
In summary, this study confirmed that in premenopausal women with idiopathic osteoporosis, the combination of teriparatide and denosumab is associated with a significant improvement in spine and hip bone mineral density .
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Hum Mol Genet: Research on the correlation between WNT11 and early-onset osteoporosis (EOOP)
Time of Update: 2022-01-08
In addition, the expression of RSPO2 and its receptor LGR5, a WNT11 target involved in bone cell differentiation, was reduced in WNT11 mutant cells .
In summary, we found that WNT11 is a new gene related to EOOP, and its loss-of-function variants inhibit bone formation through Wnt canonical and non-canonical pathways .
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Pulmonary hypertension in connective tissue disease: new evidence?
Time of Update: 2022-01-08
Pulmonary hypertension is a well-known complication in CTD, especially SSc 10% of SSc patients will develop PAH in their lifetimeTherefore, the early diagnosis of PH in CTD patients is challenging .
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A new treatment for osteoarthritis!
Time of Update: 2022-01-08
At least 242 million people worldwide suffer from hip / knee OA the narrative clinicians will review recent advances in therapies using existing drugs, and discuss new research is currently at an advanced stage (at least in a phase II trial) treatment of OA therapyTargets bone and cartilageTarget bone and cartilage Target bone and cartilageRecent studies have failed to prove that bisphosphonates improve the structure or symptoms of knee OA .
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ARD: Impaired fertility in men diagnosed with inflammatory arthritis: results of a large multicenter study (iFAME-Fertility)
Time of Update: 2022-01-08
To analyze statistical IA influence on fertility, according to the diagnosis of age at the time of the patient groups: ≤ diagnosis 30 years old (pre-peak child-bearing age), 31-40 years of age (peak period) and ≥ 41 years of age (post-peak) .
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J Am Acad Dermatol: Study on the efficacy and safety of cathepsin S inhibitors in patients with moderate and severe psoriasis
Time of Update: 2022-01-08
Approximately 20% of patients with psoriasis are moderate to severe and require systemic treatment with cytokine-targeted biological agents .
The primary endpoint was the proportion of patients who achieved a Psoriasis Area and Severity Index (PASI) -75 response after 12 weeks of treatment .
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Oxid Med Cell Longev: Anti-osteoporosis effect of psoralen components on osteoporosis animal models and its possible mechanism
Time of Update: 2022-01-07
Oxid Med Cell Longev 2021;2021Lin Z, Zheng J, Chen J,Antiosteoporosis Effect and Possible Mechanisms of the Ingredients of Fructus Psoraleae in Animal Models of Osteoporosis: A Preclinical Systematic Review and Meta-Analysis.
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ARD: Metagenomic association study reveals disease-specific landscape of gut microbiota in patients with systemic lupus erythematosus in Japan
Time of Update: 2022-01-07
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese.
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese.
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Targeting B cells, new CD19 CAR-T construct enters autoimmune diseases
Time of Update: 2022-01-07
Recommended reading: Encoding IL-2, Moderna's first mRNA autoimmune drug completed the first patient administrationYimai Meng broke the news ➤Stem cells used in autoimmune disease stem cells play a key role in maintaining tissue integrity and stress-driven regeneration.
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ARD: In vitro mass spectrometry analysis reveals bone marrow pro-inflammatory features in the synovial fluid of psoriatic arthritis
Time of Update: 2022-01-07
In this study, mass spectrometry flow cytometry (CyTOF) combined with transcriptomics analysis was used to generate matched high-dimensional data sets of PsA synovial fluid (SF) and blood leukocytes, with the purpose of identifying cells in vitro in unstimulated lymphoid and bone marrow cells Factor generation .
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ARD: B cell depletion impairs the CD8+ T cell response induced by vaccination in a type I interferon-dependent manner
Time of Update: 2022-01-07
Objective: monoclonal anti- CD20 antibody rituximab is often used in the treatment of lymphoma and self- immune diseases, can effectively remove circulating B cells .
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Arthritis Rheumatol: Risk factors for diastolic dysfunction in patients with systemic sclerosis and its impact on mortality
Time of Update: 2022-01-07
Recently, a research article was published in Arthritis & Rheumatology, an authoritative journal in the field of rheumatic immunology , which aims to identify independent risk factors for diastolic dysfunction (DD) in patients with systemic sclerosis (SSc), and to evaluate the effects of DD on the death of SSc patients The impact of the rate .
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Arthritis Rheumatol: Oral uric acid-lowering drugs intensify uric acid-lowering treatment of erosive gout
Time of Update: 2022-01-07
immunityThe researchers conducted a two-year double-blind, randomized, controlled trial on 104 erosive gout participants who received oral uric acid-lowering therapy (ULT) and serum uric acid ≥ 0.
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Eur Respir J: The relationship between fine particulate matter and interstitial lung disease in patients with rheumatoid arthritis
Time of Update: 2022-01-07
The researchers used a new (generalized) calculation method based on the time quantile of the event to estimate the potential association between the onset of rheumatoid arthritis-ILD and the exposure mixture of all seven PM2.
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CHMP recommends Saphnelo for systemic lupus erythematosus
Time of Update: 2022-01-07
The drug has been recommended as an add-on therapy for the treatment of adult patients with moderate to severely active autoantibody-positive systemic lupus erythematosus (SLE) .
AstraZeneca’s Saphnelo has been shown to be effective in reducing the overall disease activity of patients with systemic lupus erythematosus .
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too difficult!
Time of Update: 2022-01-07
For other solid malignancies, such as thyroid cancer, breast cancer and reproductive system cancer, liver cancer, colon cancer, lung cancer and pancreatic cancer , the risk of female SLE patients is also higher than that of the general population (Table 3) .
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Nature breakthrough!
Time of Update: 2022-01-04
On December 15, 2021, Chen Ting from the Beijing Institute of Life Sciences and Chang Jianmin from Beijing Hospital jointly published a research paper entitled "Anatomically distinct fibroblast subsets determine skin autoimmune patterns" in Nature Online.
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Nature: Chen Ting's team from Beisheng Institute reveals the mechanism by which fibroblasts regulate the occurrence of autoimmune diseases
Time of Update: 2022-01-04
The study revealed the important role of skin fibroblasts in vitiligo disease through single-cell transcriptome sequencing, mouse models and a series of genetic experimental methods: fibroblasts are the only necessary to recruit and activate autologous CD8+ T cells The responsiveness of fibroblasts in different parts to IFN-γ determines their ability to recruit CD8+ T cells and determines the location preference of vitiligo .
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The "trivial matter" of catching a cold cannot be taken lightly by patients with rheumatism!
Time of Update: 2022-01-03
In addition, patients with rheumatism often take immunosuppressants, glucocorticoids or biological agents for treatment, their own immunity is lower than that of normal people, and they are more likely to increase the risk of infection .
Sometimes rheumatism patients have repeated colds that indicate low immunity and need to reduce the dose of hormones or immunosuppressants .
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Immune cell research guide: how to choose T cell markers
Time of Update: 2022-01-03
In addition to cytokines, helper T cell subsets are also characterized by the expression of different surface protein markers and transcription factors .
Like various helper T cell subsets, cytotoxic T cells also express specific transcription factors and produce different cytokines and effector molecules .
