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J Am Acad Dermatol: Study on the efficacy and safety of cathepsin S inhibitors in patients with moderate and severe psoriasis

 Last Update: 2022-01-08
 Source: Internet
 Author: User

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Approximately 20% of patients with psoriasis are moderate to severe and require systemic treatment with cytokine-targeted biological agents
.

However, some patients either have no effect or develop anti-drug antibodies, which reduces the therapeutic effect

Cathepsin S is a cysteine protease that can activate the pro-inflammatory cytokine interleukin (IL)-36γ and play a pathogenic role in psoriasis
.

RO5459072 is a selective, effective cathepsin S inhibitors for the treatment of psoriasis, including itself includes immune diseases developed

immunity

The median treatment time was 67 days
.

After 12 weeks of treatment, the average steady-state blood concentration (±SD) of RO5459072 was 1290 (±614) ng/mL

Infect

We believe that RO5459072 has no therapeutic effect in this trial, which indicates that there is redundancy in the IL-36-dependent pro-inflammatory pathway in psoriasis
.

Cathepsin S activity is significantly up-regulated in psoriatic skin

In conclusion, targeting cathepsin S-mediated IL-36 activation with a highly effective and selective cathepsin S antagonist has no therapeutic effect on psoriasis
.

The mechanism of action of RO5459072 may be too specific, allowing other proteases and/or cytokines to drive the psoriasis phenotype

Literature source: Gadola SD, Färber P, Posch MG, An open-label Phase 2A study investigating the efficacy and safety of a cathepsin S inhibitor in patients with moderate to severe psoriasis, J Am Acad Dermatol 2021 Dec 11;

Gadola SD, Färber P, Posch MG, An open-label Phase 2A study investigating the efficacy and safety of a cathepsin S inhibitor in patients with moderate to severe psoriasis, J Am Acad Dermatol 2021 Dec 11;

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