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Purpose: Changes in the intestinal microbiome are related to the pathogenesis of systemic lupus erythematosus (SLE) .
However, a comprehensive view of the SLE gut microbiome and its interaction with the host remains to be revealed .
This study aims to reveal the changes in the gut microbiota related to SLE and its interaction with the host through a comprehensive metagenomic range association study (MWAS) and corresponding comprehensive analysis .
However, a comprehensive view of the SLE gut microbiome and its interaction with the host remains to be revealed .
This study aims to reveal the changes in the gut microbiota related to SLE and its interaction with the host through a comprehensive metagenomic range association study (MWAS) and corresponding comprehensive analysis .
Method: Whole metagenomic shotgun sequencing technology has many advantages compared with conventional 16S ribosomal RNA sequencing, such as higher classification resolution and suitability for functional analysis
.
Method: Whole metagenomic shotgun sequencing technology has many advantages compared with conventional 16S ribosomal RNA sequencing, such as higher classification resolution and suitability for functional analysis
.
Results : Through species-level phylogenetic analysis, this study identified and verified the increase of Streptococcus intermedius and Streptococcus angina in SLE patients
.
Conclusion: The MWAS of this study and subsequent comprehensive analysis revealed SLE- related changes in the gut microbiome and its interaction with the host , which helps us understand the relationship between the microbiome and SLE .
Source:
Tomofuji Y, Maeda Y, Oguro-Igashira E , et al .
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese.
Annals of the Rheumatic Diseases2021; 80: 1575-1583.
Metagenome-wide association study revealed disease-specific landscape of the gut microbiome of systemic lupus erythematosus in Japanese.
Annals of the Rheumatic Diseases2021; 80: 1575-1583.
, et al Annals of the Rheumatic Diseases80: Leave a message here
