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NEJM: Results of phase III clinical studies of ruxotinib in vitiligo are promising
Time of Update: 2022-10-25
Phase III clinical studies have demonstrated that ruxotinib significantly improves skin lesion repigmentation in vitiligo patients, but has an increased risk of acne and pruritus.
Phase III clinical studies have demonstrated that ruxotinib significantly improves skin lesion repigmentation in vitiligo patients, but has an increased risk of acne and pruritus.
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Response of hydroxychloroquine PK to exposure to lupus during pregnancy
Time of Update: 2022-10-25
Hydroxychloroquine (HCQ) is considered by the American College of Rheumatology and the European League Against Rheumatism to be the gold standard immunomodulatory drug for SLE complicated by pregnancy due to its safety, prevention of disease onset and improved pregnancy and neonatal outcomes.
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How to identify IgG4-related diseases? The director imparts the criteria for classification and diagnosis
Time of Update: 2022-10-25
Summary of identification points:IgG4-RD vertebral body involvement is rare, but common sites such as salivary glands and lacrimal glands are not affected;Pathological: more myofibroblast infiltration, ALK (+);Histochemistry: IgG4/IgG<40%;Moderate to high-dose hormonal therapy does not respond well, and new lung mass.
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Clinical strength training for knee osteoarthritis
Time of Update: 2022-10-25
Steps:1) Supine position, both lower limbs straight;2) Tighten the quadriceps, that is, the muscles in front of the thighs, and also use a little force to help the knees press down to tighten and bulge the muscles in front of the thighs;3) Relax after maintaining for 5s and repeat 10-15 times.
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The hot content that has attracted much attention in the field of gout in 2022 will be explained in one article!
Time of Update: 2022-10-21
Professor Zhang Xuewu of Peking University People's Hospital explained the progress of the diagnosis and treatment of gout, from the younger trend of hyperuricemia, the clinical manifestations of gout, to the latest NICE gout guidelines, and the EULAR conference gout field of gout to introduce the diagnosis and treatment of gout.
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A new addition to the field of RA therapy is here, and selective JAK inhibitors are shining
Time of Update: 2022-10-21
*For medical professionals onlyA powerful new weapon has been added to the field of RA treatment, and selective JAK inhibitors unlock new ideas for RA relief. Rheumatoid arthritis (RA) is a chronic, h
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RA actually caused "breathing pain"? Hear what the experts have to say
Time of Update: 2022-10-21
Professor Lin He pointed out that according to post-marketing surveillance data and safety data in clinical trials, patients with RA have a low incidence of ILD after receiving abatacept [16-17], and no lung damage caused by treatment has been found in clinical practice.
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How can the five abnormal mechanisms of T cells in systemic lupus erythematosus inspire targeted therapy? Latest review
Time of Update: 2022-10-21
T cell phenotypic changes CD4+ T cells modulate the immune response by providing co-stimulatory signals and cytokines, which are key drivers of the SLE autoantibody response, and the cellolytic activity of CD8+ T cells can cause functional impairment in SLE patients.
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Who are at high risk of arthritis? How can it be prevented? Professor Li Fen will take you to clarify in one article!
Time of Update: 2022-10-20
*For medical professionals only, it is only for medical professionals to read and listen to the field of experts, telling about the high risk of arthritis and prevention measuresArthritis is one of th
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Rheumatism with hormones, bones are mothed by "sugar"
Time of Update: 2022-10-20
*For medical professionals to read and refer to glucocorticoid osteoporosis, collect this article to understandintroductionGlucocorticoids have powerful anti-inflammatory and immunosuppressive effects [1], and are used by about 1% of adults worldwide for long-term treatment of a series of rheumatic diseases such as rheumatoid arthritis and systemic lupus erythematosus [2].
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Express psoriasis symptoms are significantly alleviated! Phase 1 trials of oral IL-17 inhibitors have yielded positive results
Time of Update: 2022-10-20
▎WuXi AppTec content team editor A few days ago, DICE Therapeutics announced that its oral inhibitor DC-806, which targets IL-17, has achieved positive results in a phase 1 clinical trial 。 These resu
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Nat Commun's Lindandane team found that ARIH1-induced ISG15 modification of cGAS promotes antiviral immunity and autoimmunity
Time of Update: 2022-10-20
This study elucidates the molecular mechanism of ARIH1, as a novel E3 ligase mediating ISG15 modification, by inducing novel post-translational modifications (mono-ISG15 modification) of cGAS,in the cytoplasmic DNA-induced antiviral immunity and autoimmunity.
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Keep the 4 major differences in mind and quickly identify these 3 types of arthritis!
Time of Update: 2022-10-20
Come to the "Doctor Station" to take a look 👇 at the source of this article: Fosun Health Doctor is responsible for this article: OrangeCopyright NoticeThis article is reproduced, welcome to forward the circle of friends- End - Call for "Medical Rheumatology and Immunology Channel" long-term recruitment of online invited authors, 1.
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It only survives a few weeks in the human body, but it saves your life countless times
Time of Update: 2022-10-20
late second dose of vaccination in group C (around 30 weeks), the researchers continued to collect data and found that germinal centers remained active until week 29, and even then, the number of B cells specific for HIV envelope proteins was still 27 times higher than at the peak of group A.
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ANBR Review of hydrogel-based biomaterials for immune system regulation
Time of Update: 2022-10-20
In a 2021 article published in Advanced NanoBiomed Research, Tay Kah Ping's team in the Department of Biomedical Engineering at the National University of Singapore reviewed the rationale for hydrogel-based biomaterials to reprogram the immune system in recent years.
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See expert support - how lupus patients reduce recurrence + hormone reduction, steadily protect kidney function and decode lupus nephritis expert living room (3)
Time of Update: 2022-10-20
Tel: 010-58302828-6808At present, 1130000+ doctors have paid attention to join us Professor Li Shaomei of the Second Hospital of Hebei Medical University said that long-term application of hormones will cause a burden on the patient's body.
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Patients who have taken these drugs in combination may not be so afraid to stop methotrexate...
Time of Update: 2022-10-20
Download the Doctor Station App and subscribe anytime, anywhere~*For medical professionals onlyClinical information, 1s reach ▎Clinical issues: Acceptance of biologic DMARDs (bDMARDs)/targeted synthesis What is the effect of stopping MTX in patients treated with DMARDs (tsDMARDs) plus MTX on disease activity and response rates?
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Patients with Sjogren's syndrome have persistent fever, weight loss... A picture to find a breakthrough
Time of Update: 2022-10-20
Therefore, in order to discover the clues of dualism, Deputy Director Shi Lianjie made such a table:Table 1 Case analysisHe dug deep again and again, and finally found a breakthrough in the following six key characteristics:Fig. 3 Case characteristics analysisAccording to the information in Figure 3, SS can only explain pain and elevated liver enzymes, but not fever, weight loss, elevated CRP, biliary abnormalities, PPD (+) and other manifestations.
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ACS Nano Qiu Wenxiu/Zhou Ying of Wuhan University of Science and Technology et al. activated innate immunity for local and systemic immunotherapy through STING signal amplifiers
Time of Update: 2022-10-20
On October 3, 2022, Qiu Wenxiu and Zhou Ying of Wuhan University of Science and Technology and Xiong Yuan of Huazhong University of Science and Technology jointly published a paper entitled "Activating Innate Immunity by a STING Signal Amplifier for Local and Systematic" online at ACS Nano (IF=18).
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CD(IF=38) is the most comprehensive! Wang Pengfei/Zhang Wenhong/Hu Zixin/Xu Chenqi evaluate the immune escape ability of Omicron subtype strains
Time of Update: 2022-10-20
iNatureWith persistent mutations in the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), many new Omicron sublines have been reported to escape neutralizing antibodies caused by inoculation and infection, including BA.
