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Cancer Cell: Discover a new target for pancreatic cancer!
Time of Update: 2020-07-30
A new study, co-led by Steven Leach of the Norris Cotton Cancer Center (NCCC) , found a direct link between these mutations and the mechanisms that regulate cell activity, laying the groundwork for future treatments that could target pancreatic cancer with this new target.
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Sci Adv : The Corey team revealed that the recognition protein for the H3.3 mutation revealed the mechanism that promotes tumor development.
Time of Update: 2020-07-30
in addition to inhibiting the MHC II immune response process, the team also found that RACK7 inhibits the expression of cell differentiation-related genes in tumor cells containing H3.3G34R mutations by interacting with the histone H3.3G34R mutation.
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Pediatr Blood Cancer: Systematic form lineage of eBV-related T-cell lymphatic disease in children.
Time of Update: 2020-07-30
!---- The systematic form of eBV-related T-cell lymphatic disease (S-EBV-T-LPD) in children consists of three main forms.
documented clinical pathological parameters, including histomorphology, immunoptype, EBV research, and T-cell receptor gene rearrangement studies.
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Lung cancer pound! AstraZeneca IMFINZI EU is about to be approved: first-line treatment of extensive small cell lung cancer (ES-SCLC)!
Time of Update: 2020-07-30
!--webeditor: "page title" - 28 July 2020 // AstraZeneca recently announced that the European Medicines Agency (EMA) Human Pharmaceutical Products Committee (CHMP) has issued an active review recommending approval for anti-PD-L 1 Therapy Imfinzi (Infifan, generic name: durvalumab, dofvaliu monotorthes), combined standard care (SoC) contains platinum chemotherapy (eposide-calpinor or oplyn-ciscosis-cisplatin), first-line treatment of patients with extensive small cell lung cancer (ES-SCLC).
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Sci Adv: I don't blame T-cells for not being active! Chinese scientists have found that cancer cells actively degrade MHC-1 molecules, so it's no wonder T-cells don't recognize cancer cells.
Time of Update: 2020-07-30
in order to study the role of SND1 in tumor proliferation, the researchers first made a purification analysis of cancer cells, identified a group of proteins associated with the action of SND1, including a group of proteins related to the endothelial network (ER), such as human white blood cell antigen-A (HLA-A), VCP, SEC61A, nuclear glycoprotein protein L7a (RPL7A) and so on.
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Head and neck tumor radiotherapy prospect.
Time of Update: 2020-07-30
and radiation therapy (radiotherapy) as a minimally invasive physical means, from the beginning of the birth to the present more than 100 years, has been an important treatment for head and neck tumors.
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Nat Immunol: New Target for Cancer Immunotherapy - NRP1.
Time of Update: 2020-07-30
CD8-T cell NRP1 deficiency joint immunological checkpoint blocking treatment can indeed improve tumor removal rate, which suggests that combined blocking PD-1 and NRP1 can provide cancer patients with more lasting systemic anti-tumor immunity and long-term remission.
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Building around the four basic problems, the diagnosis and treatment principles of the guidelines for head and neck squamous cancer with unknown primary causes.
Time of Update: 2020-07-30
head and neck squamous cancer, !---- which is unknown to the primary brain, is a type of heterogeneous clinical syndrome, with neck metastatic cancer as the first manifestation or first detected by th
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Radiology: Coronary CT can be a stone with more than a bird! Lung embolism, cancer, osteoporosis can also be detected.
Time of Update: 2020-07-30
Jia Chongfu, etc., said that in the coronary CT image evaluation process, in addition to evaluating heart disease change, should also pay attention to the corresponding scanning range of ostic lesions, in the absence of increased radiation dose of the early detection of extra-cardiac lesions has important clinical significance.
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Lancet Diabetes and Endocrinology: These substances are destroying health, causing obesity, infertility, cancer and other problems.
Time of Update: 2020-07-30
analyzed the literature on the series, the researchers found that PFAS exposure appeared to be closely associated with obesity, impaired sugar tolerance, gestational diabetes, weight loss at birth, decreased semen quality, polycystic ovary syndrome, endometriosis and breast cancer.
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Dev Cell. Miao Guangxia and others have revealed for the first time the molecular mechanisms of new connections between cells in the body.
Time of Update: 2020-07-30
In this study, the researchers first described how border cells attached to the egg cells after the migration, and how to establish a new connection with the centripetal cells, using the results of fixed samples and living images.
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Why does the cancer return? Why is it transferred?
Time of Update: 2020-07-30
cancer stem cells are a small number of cells in tumors, also known as "tumor initiation cells." like normal stem cells, cancer stem cells have the ability to renew themselves and produce different offspring.
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Gut: Brush your teeth and prevent cancer! Periodontal disease increases the risk of cancer!
Time of Update: 2020-07-30
the study's author, Harvard T.H. Mingyang Song, assistant professor of clinical epidemiology and nutrition at the Chan School of Public Health, said: "People with periodontal disease and more tooth loss have a higher risk of both gastrointestinal cancers, even after adjusting other major risk factors.
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Eur J Epidemiol: Studies have shown that excessive citrus intake increases the risk of skin cancer.
Time of Update: 2020-07-30
, researchers at the University of Saclay in France produced the results of a European Cancer and Nutrition Prospective Survey (EPIC), which involved 520,000 participants and looked at a potential link between citrus intake and skin cancer risk.
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Clini Cancer Res: Navu suprets treatment for advanced platinum-resistant urethria skin cancer.
Time of Update: 2020-07-30
exploratory endpoints are biomarker analysis of safety and tumor mutation load (TMB), PD-L1, and previously clear mutation characteristics.
high TMB is associated with ORR, PFS, and OS improvement (p.lt;0.05).
TMB joint PD-L1 can better predict ORR, PFS and OS than single-use PD-L1.
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Poziotinib treats HER2 Exon20 inserted mutation non-small cell lung cancer: THE ZENITH20 trial yielded positive results.
Time of Update: 2020-07-30
"We see Poziotinib as a significant step forward for patients with this deadly disease," said Joe Turgeon, president and chief executive officer of Spectrum Pharmaceuticals.
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Talk about the "bone safety" management related to breast cancer treatment.
Time of Update: 2020-07-30
a number of clinical studies and Meta analysis results show that, on the basis of standard radiotherapy, chemotherapy, endocrine therapy after breast cancer, the addition of bisphosphonate treatment for postmenopausal patients can significantly reduce the risk of recurrence metastasis, distant metastasis and bone metastasis, and significantly reduce the risk of breast cancer-related death, the current ASCO guidelines recommend bisphonate as postmenopausal (including premenopausal use of ovarian function inhibitors patients) breast cancer assisted endocrine treatment.
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SCIENCE: Why do tumor cells develop resistance?
Time of Update: 2020-07-30
recently, researchers described SIM in a variety of in vitro and in vivo models of human cancer, with non-toxic drug selection, unusually enhancing adaptability at the expense of internal health costs.
the model proposes synthetic lethal strategies to minimize resistance to anti-cancer treatments.
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Nat Nanotechnol: Research reveals new mechanisms for cell long-range communication.
Time of Update: 2020-07-30
researchers used an artificial matrix called hydrogel to see if its structure played a role in EVs navigation.
'hydrogel needs to have a hard skeleton to provide some kind of structure, but after pressure it must also be relaxed enough to readjust itself over time, which allows EVs to move.
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Clini Cancer Res: PD-L1 expression is associated with the prognosis of new complementary chemotherapy for triple-negative breast cancer.
Time of Update: 2020-07-30
therefore, the study used a quantitative immunohistometal method to detect the expression of PD-L1 in tumor cells and immune cells to assess the correlation between PD-L1 expression and the benefits of combined chemotherapy using new auxiliary defertilated in TNBC patients.
