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Collection: History of human tumor immunotherapy: from history to the future.
Time of Update: 2020-07-31
catalog , history of immunodevelopment second, immunology principle THIRD, major anti-cancer immunotherapy IV, immunotherapy V, immunotherapy toxicity and efficacy assessment VI, the interpretation of ICIs resistance 7, clinical application , immune system is a multicellular animal specialization system The primitive basic mechanism sexist in single-celled animals is the basis of complex mechanisms after multicellularization, and such as the molecular system CRISPR-Cas system in single-celled animals is an immune mechanism that maintains single-cell stability.
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Angew Chem: Our scientists have developed D-type peptide suppression immunology checkpoints for cancer immunotherapy!
Time of Update: 2020-07-31
their method is based on the specific blocking of immune checkpoints based on stable "mirror" peptides.
the Development of D-Peptide D-TBP-3 can effectively block the interaction between TIGIT and PVR, stabilize protease, and inhibit the growth and metastasis of anti-PD-1 drug-resistant tumor models.
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Develop a new model of breast cancer causes!
Time of Update: 2020-07-31
researchers say the model balances the relationships and potential interactions between factors we now know that women can control, including alcohol consumption, hormone replacement therapy, overweight and obesity, and areas of public health policy that affect how people are affected by social factors.
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Commun Biol: New findings make leukemia treatment more effective!
Time of Update: 2020-07-31
July 25, 2020 /PRNewswire/ -- In the latest issue of Communications Biology, Professor Jindrich Cinatl from the Institute of Medical Virology at Goethe University and Professor Martin Michaelis from the School of Biological Sciences at the University of Kent report on their research on different cell lines by Nairabin.
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Professor Cheng Ying talks about the progress and development trend of small cell lung cancer treatment.
Time of Update: 2020-07-30
CSCO Changbai Cancer Summit Forum has been adhering to the "followed education and academic emphasis" concept, whether at the expert level or topic settings and other aspects are very attentive, that is, to take into account the training and education of primary doctors, but also pay attention to the dissemination of new progress, new information, every year will give the national tumor with a rich content, comprehensive academic event.
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Peripheral T-cell lymphoma treatment - late-stage difficult-to-treat challenges remain, the efficacy of new drugs can be expected.
Time of Update: 2020-07-30
class is histone deacetylase (HDAC) inhibitors, this new drug has been listed at home and abroad, its overall efficiency of about 20%, OS can reach more than 1 year, for some patients with relapse difficult to cure brought a new breakthrough.
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Clini Cancer Res: The SMARCA4 mutation predicts the prognosis in lung cancer patients.
Time of Update: 2020-07-30
!---- background: The SMARCA4 mutation is one of the most common recurrent variants in non-small cell lung cancer (NSCLC), but its relationship to other genomic abnormalities and clinical effects have not yet been determined.
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Case: Premenopausal HR and young patients with moderate-risk breast cancer endocrine treatment thinking.
Time of Update: 2020-07-30
In the ASTRRA study, the TREATMENT of TAM 5 years combined with ovarian function inhibition (OFS) was 2 years compared with TAM treatment for 5 years, significantly improving the 5-year disease-free survival (DFS) rate, with an absolute benefit rate of 3.6%, while significantly improving total survival (OS), reducing the risk of death by 69%, so the benefits of OFS joint endocrine therapy were more pronounced for patients with premenopausal HR plus high-risk patients.
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EMBO Mol Med: Zengmu St. team reveals the molecular mechanism and function of INSL5 regulating tumor sugar metabolism.
Time of Update: 2020-07-30
the study first reported that EBV infection of the diseased nasopharyngeal epithelial cells led to an increase in insl5 (Insulin-like peptide 5), in which INSL5 and its receptor GPCR142 axis promote the expression of glycoenzyme-related genes by activating the STAT5 signaling pathway in the cell, which in turn affects the reprogramming of glycometabolisaandic metabolism and ultimately promotes the progression of nasopharyngeal cancer.
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2020 POST-ASCO Professor Huang Cheng: Take a look at the hot spots of lung cancer research, understand the future direction of development, and explore more breakthrough opportunities.
Time of Update: 2020-07-30
The first aspect of is early lung cancer, and in recent years, the auxiliary or new adjuvant targeted therapy, especially the third generation of EGFR-TKI-assisted therapy, has made great progress.
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How to treat methytlith-positive late-stage solid tumor? The effectiveness of the new T-cell therapy TC-210 is significant.
Time of Update: 2020-07-30
TCR2, a !---- immunotherapy company that is developing a range of new T-cell therapies for cancer patients, is currently in phase I/II clinical phase to treat methlopathy-positive non-small cell lung cancer (NSCLC), ovarian cancer, pleural/peritoneal lylthyosome and bile duct cancer.
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"Macrophage immunotherapy" CT-0508 treatment of solid tumors: better than traditional cell therapy.
Time of Update: 2020-07-30
carISMA Therapeutics, !---- a biopharmaceutical company focused on the development of immunotherapy, today announced that the U.S. Food and Drug Administration (FDA) has approved the application for a new research drug (IND) for its main candidate drug, CT-0508, which targets human epidermal growth factor receptor 2 (HER2) inaniated antigen receptor macrophage (CAR-M) therapy.
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Dev Cell: Scientists have found that PRC1 plays a role in genetic errors and cancer.
Time of Update: 2020-07-30
focus: 1, there is a collection of fistriatal cross-linked protein PRC1 to produce friction 2, anti-microtube sliding scales and filament speed into a linear relationship 3, friction and PRC1 number of proportion, but not overlapping length or PRC1 density 4, PRC1 acts as a viscous damper, regulating the cell division in microtube velocity in split cells requires the assembly adjustment of spinning body equipment.
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Nat Med: The first Phase III trial found that metformin improved working and statement memory in children with brain tumors who received radiotherapy.
Time of Update: 2020-07-30
for brain tumors in children who received cranial radiotherapy, metformin significantly improved their working memory and statement memory function, repairing white matter damage, compared to placebos.
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Nat Commun: All-drug affects breast cancer metastasis on animal models through the IL-6 pathway.
Time of Update: 2020-07-30
in order to further reveal the mechanism of anaesthetic and to find potential targets to eliminate the effects of narcotic drugs in promoting tumor metastasis, they screened for changes in cytokine cytokines in blood and lung tissue shorter hours after surgery (i.e. three hours after surgery and one day after surgery).
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China's State Drug Administration will give priority to reviewing Pamiparib's application for new drugs.
Time of Update: 2020-07-30
the key Phase II part of the Phase I/II clinical trial (NCT03333915), which recruited at least 113 Chinese patients with advanced epithelial ovarian cancer (including fallopian tube or primary peritoneal cancer) or advanced endometrial-like epithelial cancer who underwent more than two standard chemotherapy sessions.
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Cancer cell: New discovery: Highly plastic cell states reveal the mechanisms of resistance of cancer cells.
Time of Update: 2020-07-30
researchers believe that by combining chemotherapy drugs with new drugs for these highly malleable cells, it is possible to avoid the emergence of drug resistance and provide more lasting relief.
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Cancer Cell: Zhang Zeda and others find 'survival signal' of prostate cancer resistance
Time of Update: 2020-07-30
the authors then demonstrated through a series of experimental methods, using a variety of tumor cells, organoids, and mouse isosome models, that the presence of interstitial cells, especially fibroblasts around tumors, can greatly promote the resistance of prostate tumors to hormone therapy.
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Come out to eat, sooner or later to return! BMJ: Fatty liver is more likely to induce heart metabolic diseases such as diabetes, hyperlipidemia and hypertension!
Time of Update: 2020-07-30
to the researchers' surprise, liver fat is more closely related to heart metabolic dysfunction than other factors, and is more insensitive to insulin.
liver fat and abdominal fat deposition, clinical biomarkers and plasma metabolomicdata are not only closely related to obesity, but also the most critical factor of heart metabolic disease.
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Sci TransL Med: Measuring two miRNA molecules in the blood can be used to assess radiation exposure.
Time of Update: 2020-07-30
In a new study, researchers at Ohio State University in the United States developed a needle-type blood test to measure radiation levels in mice.
People who exposure to dangerous radiation levels need immediate treatment because of damage to their gastrointestinal tract and bone marrow.
