-
Front Oncol: Hefei Research Institute of the Chinese Academy of Sciences, etc. revealed that AURKA rs2273535 T-A polymorphism is associated with an increased risk of cancer.
Time of Update: 2020-07-30
!---- Recently, the Jinfu team of the Hefei Institute of Physical Sciences of the Chinese Academy of Sciences demonstrated that aurora kinase AURKA rs2273535 T-gt;A polymorphism was associated with an overall increase in cancer risk, especially breast cancer.
-
Relacorilant Treatment cushing Syndrome: Phase III trial sat trials have been conducted.
Time of Update: 2020-07-30
pharmaceutical company Corcept recently announced that it has launched a Phase III clinical trial (GRADIENT study) for relacorilant to treat adrenal cushing syndrome.
We hope that Relacorilant will be a treatment option for these patients." GRADIENT study is a double-blind, placebo-controlled Phase III clinical trial that plans to recruit 130 patients in the United States and Europe.
-
Nat Chem: Seven years later, it's making progress again! For the first time, British scientists have observed the formation of four spiral dna in living cells.
Time of Update: 2020-07-30
the researchers, entitled "Single-visualization of DNA G-quadruplex formation in live cells", used a G4-specific fluorescent probe (SiR-PyPDS), which enables real-time single-molecule detection of a single G4 structure in a living cell.
-
Nature Cell Biology: The Jiang Hao team revealed that AKAP95 can regulate gene splicing and tumor generation through phase separation.
Time of Update: 2020-07-30
in all, the study revealed that some gene-regulating proteins, such as AKAP95, not only need to separate to form condensate, but also need to have good activity to regulate gene expression and cancer within the range of a suitable coagulation biophysical properties.
-
Therapeutic vaccine TG4001 combined with Avelumab for advanced HPV-positive cancer: clinical trials yielded positive results.
Time of Update: 2020-07-30
the purpose of this exploratory Ib / II trial is to assess the safety and efficacy of TG4001 and immunocheckpoint inhibitors in combination treatment of invasive, recurrent and/or metastatic HPV16-positive cancers.
a total of 34 cases of assessable oral,, cervical or other HPV16-positive cancer patients were enrolled in the .
-
J Hepatol: Maternal obesity will increase the probability of liver cancer in the offspring, and it can accumulate for generations!
Time of Update: 2020-07-30
In a new study published in the journal Journal of Hepatology, researchers found a microRNA in obese female mice that appears to transmit susceptibility to liver cancer and increase the risk of liver cancer in children and offspring.
-
Professor Yang Tian: The 2020 edition of cSCO Primary Liver Cancer Diagnosis and Treatment Guidelines updates the key points of interpretation, focusing on immuno-targeted combination therapy.
Time of Update: 2020-07-30
brave man's research - IMbrave150 study deserved lying for 1A evidence in the new edition of the Guide, advanced liver cancer first-line and second-line system treatment updates are larger, there are three immuno-combined targeted treatment options written to the first-line treatment, including atirezumab anti-combination bevalu zuma The "T-A" scheme, the Revenatini joint Paboli bead monotag, apatierini united Karelli bead monobden, the latter two options are recommended at level III, and the "T-A" scheme is the highest level of I recommendation.
-
Tumor markers rise 50 times, million did not expect this is the reason! The Inspection Section must be vigilant...
Time of Update: 2020-07-30
Figure 2 is the blood uric acid level (unit: umol /L) in patients 2014-2020, the possible mechanism is also described in the literature: (1) gout is a metabolic disease characterized by hyperuric acid emis, the most common clinical manifestations of which are recurrent acute monoarthritis, and the incidence of gout and kidney stones significantly increased.
-
Cell Res: Fudan University has released a three-negative breast cancer treatment plan that allows patients to go from mountains to mountains.
Time of Update: 2020-07-30
According to !---- the 2018 International Agency for Research on Cancer (IARC), breast cancer has a global incidence of 24.2 percent of female cancers, the highest rate among women, with 52.9 percent
-
Nat BME: Classification of T-cell activation through autologous fluorescence imaging.
Time of Update: 2020-07-30
Results: Spontaneous fluorescence life imaging of T cells, combined with machine learning, is an accurate tool for non-destructive non-label evaluation of the activation state of T cells.
-
JAMA: Drug prevention of breast cancer, what factors to weigh, four drugs how to choose?
Time of Update: 2020-07-30
a 2019 study at the Large Breast Target Center found that the first two tools were more accurate, with more consistent risk in the population with the actual observed risk; the pros and cons of the four preventive drugs currently, there are two main types of drugs used to reduce the risk of breast cancer: (1) selective estrogen receptor regulators (SERM), including tamoxifen and reloxifen; typical preventive drug use period is 5 years.
-
NEJM: Metastatic transparent cell sarcoma - case reports.
Time of Update: 2020-07-30
The patient !---- a 62-year-old man who was treated for five months due to bloating, diarrhea and weight loss (8 kg).
the patient underwent an ultrasound-led biopsy of abdominal lesions, and histopathological analysis revealed a transparent cell sarcoma (shown in Figure B).
-
Gastric Cancer: Effect of poblinib combined with yewol and quordzumab in the treatment of patients with HER2-positive advanced gastric cancer.
Time of Update: 2020-07-30
this prospective, multi-center, open-label, Phase I/II study identified the maximum tolerable dose (MTD) and evaluated the safety and efficacy of pozidinis combined yewol and quordlome in patients with HER2-positive advanced gastric cancer (GC).
-
Cell Discov: Seaweed extract is more effective at suppressing SARS-CoV-2 than Redsewe.
Time of Update: 2020-07-30
researchers performed a dose response study on mammalian cells, called EC50 (an acronym for the effective concentration of a compound that inhibits 50% viral infection).
-
Mol Cell: The implicationofous effects of androgen receptor structure on prostate cancer.
Time of Update: 2020-07-30
previous studies have shown that androgen receptors (ARs) combine testosterone to dissose and form dipolymers from the heat shock protein, and enter the nucleus to bind to DNA, further collecting co-activation factors and other active complexes that promote protein formation, which in turn regulates the specific genes necessary for growth and development.
-
Precision treatment based on gene-type type is the future development direction of giST treatment of gastrointestinal mesomas.
Time of Update: 2020-07-30
relapsed transfer of GIST multi-line drug resistance treatment strategy is well known, GIST is the development of relatively slow tumor, many patients in the third-line treatment, the general condition is still good.
-
AJCN: A Mediterranean diet may reduce the incidence of colorectal cancer.
Time of Update: 2020-07-30
, a Meta analysis published in The American Journal of Clinical Nutrition further studied the relationship between the Mediterranean diet (MD) and the incidence and mortality of colorectal cancer (CRC).
-
Cancer Dis: A new breakthrough in targeted treatment for three negative breast cancers! The BBOX1 gene is the key!
Time of Update: 2020-07-30
researchers at the University of Texas Southwestern Medical Center (UTSW) in a new study, said one of the oxygen-sensitive enzyme family can provide a viable target for triple-negative breast cancer (TNBC).
-
Nat Nanotechnol: Research reveals new mechanisms for cell long-range communication.
Time of Update: 2020-07-30
researchers used an artificial matrix called hydrogel to see if its structure played a role in EVs navigation.
'hydrogel needs to have a hard skeleton to provide some kind of structure, but after pressure it must also be relaxed enough to readjust itself over time, which allows EVs to move.
-
Clini Cancer Res: PD-L1 expression is associated with the prognosis of new complementary chemotherapy for triple-negative breast cancer.
Time of Update: 2020-07-30
therefore, the study used a quantitative immunohistometal method to detect the expression of PD-L1 in tumor cells and immune cells to assess the correlation between PD-L1 expression and the benefits of combined chemotherapy using new auxiliary defertilated in TNBC patients.
