Front Oncol: Hefei Research Institute of the Chinese Academy of Sciences, etc. revealed that AURKA rs2273535 T-A polymorphism is associated with an increased risk of cancer.

!---- Recently, the Jinfu team of the Hefei Institute of Physical Sciences of the Chinese Academy of Sciences demonstrated that aurora kinase AURKA rs2273535 T-gt;A polymorphism was associated with an overall increase in cancer risk, especially breast cancer.research on AURKA rs2273535 T?gt; A Polymorphism Associated With Cancer Risk: A System With With Meta-Analysis, published in Frontiers in Oncology.Aurora kinase A (AURKA) is a cell cycle regulation of serine/suine kinase that promotes the cell cycle process.it plays an important role in regulating the transition of cells from the G2 phase of silk division to The M. The association between Polymorphism and cancer risk in aAURKA rs2273535 T-gt;A polymorphism has been studied, but the results have been mixed.study conducted a comprehensive analysis of 36 "case-control studies", including 22,884 cancer cases and 30,497 healthy controls.calculate the advantage ratio and 95% confidence interval to determine their correlation. theanalysis showed that aurKA rs2273535 T-gt;A polymorphism increased the overall risk of cancer, and the results of the three model parameters were: pure conjugon model OR.17, 95% CI, 1.04-1 .33; recessive model OR.1.15, 95% CI- 1.05-1.25; alleling model OR is 1.07, 95% CI is 1.02-1.13.stratified analysis by type of cancer further suggests that this polymorphism is associated with an increased risk of breast cancer.the study was completed in collaboration with Wang Meng, an associate researcher at the Hefei Institute of Stem Cells and Regenerative Medicine of the Chinese Academy of Sciences, and Zhu Meiling, a doctor at Xinhua Hospital affiliated with Shanghai Jiaotong University School of Medicine.research work has been supported by the National Natural Science Foundation of China, the Foundation of the President of Hefei Research Institute (Spark Fund) and so on..