SCIENCE: Why do tumor cells develop resistance?
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Last Update: 2020-07-30
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Source: Internet
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Author: User
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In microbes, an evolutionaryly conservative mechanism can promote its adaptation to harsh conditions through stress-induced mutations (SIMs). !----similar processes may be the basis for cancer progression and treatment failure in humans.recently, researchers described SIM in a variety of in vitro and in vivo models of human cancer, with non-toxic drug selection, unusually enhancing adaptability at the expense of internal health costs.a genome-wide approach that identifies the mechanical target (MTOR) of rapamycin as a pressure sensor that mediates sims of multiple cancer types and conditions.these observations are consistent with the two-stage model of drug resistance, in which the initial rapid expansion of genetic diversity is offset by internal adaptive punishment and then normalized to full adaptation under new conditions.the model proposes synthetic lethal strategies to minimize resistance to anti-cancer treatments..
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