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Fda approved Kesimpta, the first and only self-injected B-cell therapy for patients with multiple sclerosis, to be injected once a month.
Time of Update: 2020-09-24
positive results from the APLIOS study in phase II of the study showed that RMS patients were biologically equivalent to Kesimpta injections with pre-installed syringes and Sensoready pens.
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JAMA Neurol: Effects of selective 5-serotonin reuptake inhibitors on stroke recurrence and depressive symptoms in stroke-surviving patients.
Time of Update: 2020-09-24
Selective serotonin reuptake inhibitors (SSRIs) are widely used to treat post-stroke depression, but studies have found that SSRIs can lead to an increased risk of cerebral hemorrhage (ICH) in the general population.
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JNNP: Guillain-Barré syndrome anti-neurothycoside antibodies associated with SARS-CoV-2 infection.
Time of Update: 2020-09-24
although there is little information on the neurological symptoms of COVID-19, there are reports describing Greene-Barre syndrome (GBS) as an acute symptom of SARS-CoV-2.
so far, anti-neuro-glycoside antibody detection (anti-GM1, anti-GD1a, and anti-GD1b) for different neural glycoside lipids represents the novelty of GBS associated with SARS-CoV-2 infection.
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Lacosaamine therapy assists in the treatment of primary systemic stoic-tymponic epilepsy in efficacy and safety: a double-blind, randomized, placebo-controlled trial.
Time of Update: 2020-09-18
The treatment of myoclonic seizures and primary systemic strong-straight seizures (PGTCS) in patients with IGE is complex, as certain anti-epileptic drugs (AEDs) may aggravate the associated type of seizure, such as arrhythmic or myoclonic seizures.
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JAHA: Relationship between blood pressure and outcome in patients with cerebral hemorrhage of different causes.
Time of Update: 2020-09-18
systolic blood pressure was associated with a higher three-month mortality rate in patients with hypertension vascular disease subspecies (trend P=0.013) and unknown source subspecies (Trend P=0.005).
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Alzheimer's and Dementia: WHICAP queue studies show that vitamin D intake is associated with dementia risk.
Time of Update: 2020-09-18
Vitamin D intake from food after adjusting for age, gender, race/ethnicity, education level, lipoprotein E (APOE)-4, physical activity, Mediterranean diet (MeDI) score, income, depression, hypertension, diabetes, cardiovascular disease and smoking The largest number of participants had a lower risk of developing dementia than the least of the participants (the risk was 0.72, 95% confidence interval of 0.54-0.97, P,0.030).
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JAHA: Growth differentiation factors 15 and NT-proBNP are biomarkers of vascular brain damage and dementia.
Time of Update: 2020-09-18
result, elevated plasma GDF15 and NT-proBNP were associated with an increased risk of MRI vascular brain damage, poor neurocognitive function, and dementia in participants over 60 years of age.
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JNNP: A tremord star? Non-invasive intervention of Parkinson's tremor: the effect of vibration stimulation.
Time of Update: 2020-09-18
For nine-hole nail tests, the ANOVA analysis of a factor condition with four levels (NoVib, 200Hz60bpm, 200Hz 20bpm, and 80 Hz) shows that this condition has a significant impact on the average completion time of the operation.
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New drugs for depression! Johnson and Johnson Spravato Nasal Spray Approved by FDA: Treat patients with severe depression with emergency suicidal thoughts/behaviors!
Time of Update: 2020-09-13
!--, 2020 / -- Johnson and Johnson (JNJ) Janssen Pharmaceuticals recently announced that the U.S. Food and Drug Administration (FDA) has approved Spravato (esketamine) CIII Nasal Spray Supplemental New Drug Application (sNDA), which is used in a combined way with oral antidepressants to treat adult patients with acute suicidal thoughts or behaviors with severe depression (MDD) and quickly reduce depressive symptoms.
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New medicine for rare diseases! FDA priority review of Hetlioz (melatonin-affected agonist): first Smith-Magillian syndrome (SMS) drug!
Time of Update: 2020-09-13
August 04, 2020 // -- Vanda Pharmaceuticals recently announced that the U.S. Food and Drug Administration (FDA) has accepted two applications filed by the company for Smith-Magenis Syndrome (SMS) and granted priority review.
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Autism Research: Gastrointestinal symptoms can affect autism in children.
Time of Update: 2020-09-12
Aug 11, 2020 /--- A new study from the University of California, Davis, has found that common gastrointestinal symptoms, such as diarrhea, constipation and bloating, are associated with sleep problems, self-harm and physical discomfort in preschool children.
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Sci Rep: Biomarkers can be used to detect brain damage.
Time of Update: 2020-09-12
August 5, 2020 /--- -- A team of scientists led by the University of Arizona and the City of Hope Institute for Translational Genomics (TGen) has identified a new family of biomarkers through proteomics and metabolomic analysis that could help treat tens of millions of patients with brain damage and potentially prevent severe long-term disability.
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Nat Med: Antony oligonucleotides using the targeted defective CLN3 gene are expected to treat Baytown disease.
Time of Update: 2020-09-12
"Our study tested a new approach: treating the expression of this disease-caused gene therapeutically using ASO, the mutant form that binds to the gene," said Jessica Centa, lead author of the paper and a graduate student at Rosalind Franklin Medical University.
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Nat Med: Using marijuana during pregnancy may increase the risk of autism in future generations.
Time of Update: 2020-09-11
Photo Source: The Ottawa Hospital recreational marijuana is legal in Canada, but that doesn't mean it's safe for pregnant and lactating women, and researchers at Health Canada and the Society of Obstetricians and Gynecologists advise these people not to use marijuana as much as possible, and they also have health tips or warnings on their packaging.
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The study found that feedback signals that characterize visual perception characteristics dominate visual sensitivity adaptation.
Time of Update: 2020-09-11
using high-resolution brain imaging, researchers found that the visual cortical symptoms of sensory orientation in the Flash-Grab effect depended largely on feedback signals.
The study used an optical illusion, the Flash-Grab effect, to separate the input and the perception-to-direction, and found that the tilting effect depended on the perception rather than the input orientation; ()
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Enhancing cancer immunotherapy, Alzheimer's disease risk genes provide new targets
Time of Update: 2020-09-10
further analysis of mice treated with TREM2 antibodies, the researchers saw that the immune cells in the tumor did change: the inhibitory macrophages decreased significantly, and T cells became abundant and active.
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New drug for Duchy muscular dystrophy (DMD)! FDA approves second 53 exon jump therapy Viltepso!
Time of Update: 2020-09-10
!-- NS Pharma, a subsidiary of Nippon Shinyaku, Japan, announced recently that the U.S. Food and Drug Administration (FDA) Viltepso (Viltolarsen) has been approved for use in patients with Duchymy muscular dystrophy (DMD) who have been genetically tested for mutations that are suitable for treatment with exon 53 skipping, which accounts for about 8% of the total number of DMD patients.
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Replacement of "fault cleaners" in the brain. Fudan Pengbo team developed three solutions
Time of Update: 2020-09-10
specifically, the researchers first used a drug to efficiently remove small glial cells from the central nervous system in adult mice without causing significant side effects.
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The study found that electrocephaloelectral asymmetry in the resting state's forehead was related to different dimensions of the split trait.
Time of Update: 2020-09-09
Although the split trait may be associated with different frequency bands of the resting frontal frontal brain electricity, there is always a negative correlation between the two, i.e. as the split trait increases, the subject may exhibit a decrease in the power of the left side relative to the right frontal leaf in the resting state.
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Science: Mitochondrials may promote the transformation of neural stem cells to neuron cells during brain development.
Time of Update: 2020-09-09
That is, how to regulate the transformation of neural stem cells into nerve cells; mitochondrials experience the fate switches that affect cells at this precise time, twice the length of a critical period in humans than in mice; and the results highlight the important function of mitochondrials, which may help researchers explain why humans develop larger brains during evolution, and how mitochondrial defects can induce neurodevelopmental diseases.
