JNNP: A tremord star? Non-invasive intervention of Parkinson's tremor: the effect of vibration stimulation.

In recent years, there has been a new interest in using peripheral vibrations to improve certain motor symptoms (tremors) of Parkinson's disease (PD).
because intervention is non-invasive and inexpensive, peripheral vibration can improve the patient's performance of motor symptoms is exciting.
, however, there is little published scientific research to support this approach.
previously, the authors demonstrated that shaking 30 s of the wrist at 80 Hz prior to exercise can improve exercise performance in healthy control and PD patients in a variety of manual tasks.
, the authors report on the development of a "Emma Watch" that provides continuous vibrational stimulation on the wrist, significantly improving the movement of the stimulated upper limbs of PD patients.
Emma Watch provides a constant vibration of 200 Hz through six small electromagnetic mechanical stimulators (three on each side of the wrist).
vibration frequency is modulation by a lower frequency, i.e. 20 bpm (heartbeat per minute) or 60 bpm.
these modulation parameters are based on the parameters of the motion function of the first patient treated with PD.
the authors tested whether Emma Watch could improve the motor function of 16 PD patients (11 women, with an average age of 63 years, ranging from 52-72 years old, Parkinson's Disease Unified Disease Classification Scale (UPDRS) III Right Upper Limb (RUL) 7 to 3, with a course of 10.5 to 6 years, and an average daily dose of 500 mg of zoopa.
was diagnosed as idyllytic PD according to the British Parkinson's Society brain bank standard and further confirmed by an abnormal dopamine transport protein single photon emission computer fault scan (SPECT).
the subjects used any non-PD drugs (psychodrives) that might affect the measurement results.
all patients were in ON condition and were assessed after 1 hour of lysophobic doba and 2 hours of dopamine agonists.
all participants have obtained written informed consent.
evaluated the performance of the device treatment through three different tasks: (1) a nine-pin hole test;
for Task 1, trainees are asked to insert nine nails into nine holes as soon as possible while timed with a stopwatch.
subjects performed tasks 2 and 3 using ink digital pens on WACOM Intuos Pro L digital tablets, with pressure levels of 8192 and a resolution of 5080 rows per inch.
internal Windows application records WACOM data (pen x/y coordinates and pressure levels) and the start and end timestamps of each task in the log file.
for both tracking tasks (STAR and SPIRAL), subjects were required to track graphics as accurately and quickly as possible on paper placed on top of the tablet surface.
For nine-hole nail tests, the ANOVA analysis of a factor condition with four levels (NoVib, 200Hz60bpm, 200Hz 20bpm, and 80 Hz) shows that this condition has a significant impact on the average completion time of the operation.
nine-pin hole test (F (3,45) s 3.8, p s 0.016, eta2 s 0.202).
after-the-fact pair comparison shows that there is a significant difference between the average completion time of 80 Hz and NoVib (p .lt;0.01, t (15) - -3.58).
results repeat previous studies using the same equipment and tasks.
the average completion time between 200Hz60bpm and NoVib (p s 0.05, t (15) s 1.713).
the average completion time is no significant difference between 80 Hz and 200Hz 60bpm (p s 0.36, t (15) s 0.941).
there was no significant difference in the average completion time between 200Hz20bpm and NoVib (p s 0.69, t (15) s 0.412).
, for the nine-hole nail test, it was demonstrated that continuous vibration at 200Hz60bpm using The Emma Watch improved tremor performance.
for STAR, spiral tracking tasks, 200Hz 60bpm also showed good results.
improved performance associated with motion speed and performance accuracy in tracking control tasks by modulation frequencies of 60 bpm and surrounding vibrations at 200 Hz during the execution of different tasks in a total of 16 PD drug patients.
, vibration at 20 bpm at a frequency of 20 Hz had no significant effect on motion performance.
Macerollo A, Holz C, Cletheror D, et al Non-invasive intervention for motor signs of parkinson's disease: the effect of vibratory stimuli Journal of Neurology, Neurosurgery and Psimsy Published Online First: 11 September 2020. doi: 10.1136/jnnp-2020-323427 Source: MedSci Originals !-- End of Content Presentation -- !-- To determine whether to log in.