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Neuron: What exactly is hearing loss that causes Alzheimer's disease?
Time of Update: 2020-09-26
Photo Source: CC0 Public Domain In an epidemiological study, researchers found that hearing loss is associated with dementia, and that the condition causes one-tenth of the 47 million cases of dementia worldwide; in this study, researchers proposed a new theory to reveal why ear impairments induce Alzheimer's disease, an explanation that researchers hope will help scientists delve deeper into the pathogenesis of Alzheimer's disease and effectively predict the risk of developing alzheimer's disease in the future.
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JAMA: Effect of in-hospital acetate treatment on the prognosis of nerve function in patients with moderate to severe trauma brain injury.
Time of Update: 2020-09-25
study was conducted at 59 emergency trauma centres in the United States and Canada, aged 15 and over, involving TBI patients with a systolic score of 12 or less and systolic pressure of 90mmHg or more in Glasgow, receiving 1g of methamphetamine and 1g of in-hospital injection 2 hours after injury Intra-hospital acetate therapy (in-hospital acetate group, n=312), in-hospital injection of 2g of amino acid and in-hospital placebo therapy (in-hospital treatment group, n=345) and in-hospital placebo therapy (placebo group; n=309).
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J Neurol Neurosur Ps: The relationship between smoking and amyotrophic lateral sclerosis.
Time of Update: 2020-09-25
recently, researchers used the results of a recently published large genome-wide association study and Mendel randomization method to reduce confusion to assess the relationship between smoking and ALS, according to a recent study published in the journal Neurology.
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Cell Death Dis: New discovery of pathogenesis of radioactive optic neuropathy.
Time of Update: 2020-09-25
study found that radiotherapy causes changes in mitochondrial dynamics by regulating mitochondrial division-related proteins Drp1 and Fis1, while producing too much reactive oxygen (ROS), which eventually leads to neuron damage and visual impairment.
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eLife: Dig deeper into the genes associated with Alzheimer's disease or hopefully help develop new targeted therapies.
Time of Update: 2020-09-25
photo source: University of Alabama at Birmingham genome-wide association study shows bin1 is a risk factor for Alzheimer's disease, says Erik Roberson, M.D. Genetics Using different methods to increase bin1 expression and measure nerve activity in the brain, the researchers found that neurons with higher BIN1 levels may be more likely to get excited and more likely to overexcite, which is important because hyperexcitability is thought to be a feature of early Alzheimer's disease.
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Acta Neuropathologica: Microvascular Damage and Hypoxia Damage: New Neuropathological Characteristics in COVID-19.
Time of Update: 2020-09-25
In patients with COVID-19, there is a growing awareness of neurological complications, but very few neuropathological cases are available, including microthrombosis and acute infarction, hypoxia changes (no specific pathology) or leaching of lymphocytes around cerebrovascular vessels.
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Acta Neuropathologica: SFPQ and Tau: Key factors leading to the rapid development of Alzheimer's disease.
Time of Update: 2020-09-25
Is consistent with the results from the human brain, in-body studies in this paper show that SFPQ is recruited into TIA-1 positive stress particles (SGs) after oxidative stress induction, and co-located with tau/p-tau in these particles, providing a possible mechanism for causing SFPQ misalposition through pathological SGs.
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Science: Solve decades of challenges! Xu Min first discovered the important role of glutamate energy neurons in sleep stabilization regulation.
Time of Update: 2020-09-25
Sleep stability is the balance between sleep duration and wakefulness and is a basic feature of the sleep-wake cycle. during waking, sleep-promoting factors build up and lead to increased sleep stres
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JAMA Neurol: Incredible! Nearly three times as many people die from dementia as previously thought!
Time of Update: 2020-09-25
14, 2020 // -- Scientists from Boston University School of Medicine and others have found that dementia may be the underlying cause of nearly three times more deaths in the United States than official records, according to a study published in the international journal JAMA Neurology.
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Acta Neuropathology: ADNC-RS is a clinical genetic risk score that predicts Alzheimer's pathology in post-mortem confirmed Parkinson's disease and Louisian dementia.
Time of Update: 2020-09-25
In the first phase of the authors' study, AD neuropathological changes (ADNC) were evaluated in 127 consecutive autopsy-confirmed PD or DLB cases from the same center, and 20 single nucleotide polymorphisms (SNPs) were found to be associated with AD risk.
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Implant a small gasket, the world's first pain instantly alleviated! The 61-year-old aunt finally dared to rub her face when she cried.
Time of Update: 2020-09-25
Last October, 61-year-old Aunt Wang of Zhangzhou suffered from right trigemular nerve pain, accompanied by right side muscle convulsions, the right face is simply "unable to touch", eating, drinking water, talking, slight touch, will be like electric shock knife cutting in general pain, at the same time, the right face and right eye also continue to twitch, the corners of the mouth are crooked.
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Acta Neuropathologica: Different clinical pathology groupings for patients with TDP-43 protein disease.
Time of Update: 2020-09-25
Although many brains have different pathological states, the authors found four identifiable clusters, the main identification of which was neuropathological changes (ADNC) in age of death and the severity of Alzheimer's disease, especially neurosomalloid plaque density.
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BMJ: HpV vaccination does not increase the risk of autologic neurodefunction syndrome in women.
Time of Update: 2020-09-25
study that did not support the 4-price HPV vaccine increased the risk of autonitatic neurodefurction syndrome such as chronic fatigue syndrome, complex area pain syndrome, or positional erect titration syndrome in women.
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Alzheimer's and Dementia: The Jia Jianping team at Xuanwu Hospital found that APOE 4 had different effects on different subtypes of Alzheimer's disease.
Time of Update: 2020-09-25
the study included 15,119 subjects, including 311 FAD patients without PSEN1, PSEN2, APP, TREM2, and SORL1 disease-caused mutations (FAD (unknown); researchers analyzed the risk effects of APOE 4 on each group.
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AUTOPHAGY: Autophagy enhancement causes complaccision.
Time of Update: 2020-09-25
ATM and its PIKK sister kinase ATR (associated with co-dysfunctional telomere disease and Rad3) play a role in DNA damage responses.
in addition to playing a role in dna damage repair in the nuclei of cells, ATMs and ATRs are also present in the cytoste.
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Cell Death Differ: The function of RPS23RG1 in neurodegenerative diseases.
Time of Update: 2020-09-25
the expression of p35 and the use of cdk5 inhibitor roscovitine can reduce the phosphorylation level of tau protein in Rps23rg1 KO mouse neurons and relieve the growth of axon obstruction.
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Aging Cell: Ibuprofen saves memory loss in aging.
Time of Update: 2020-09-25
, however, 8 months of ibuprofen therapy significantly improved short- and long-term memory at 18 months of age nfkb1-/- barnes maze test allows researchers to analyze search strategies between groups in more detail.
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Crit Care: Neurological outcomes in patients with cardiac arrest in in vitro circulatory CPR.
Time of Update: 2020-09-25
result, ECPR treatment in patients with cardiac arrest in hospitals can lead to good neurological outcomes for most patients, and the survival rate of patients is higher than that described in the CCPR literature.
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Acta Neuropathologica: Analysis of the causes associated with the lesions phase of myelin regeneration damage from multiple sclerosis.
Time of Update: 2020-09-25
Based on the density and distribution of single-nucleocytes from blood sources and small glial cells resident in the central nervous system (which are subsequently summarized as myelin-like cells), activity, in activity, in activity and mixed lesions can be distinguished according to the descriptions in the updated MS histological classification.
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Hypertension: Anti-hypertensive drugs and risk of depression.
Time of Update: 2020-09-25
researchers found that the continued use of angiosin drugs, calcium antagonists and beta blockers was associated with a significant reduction in the risk of depression, compared with the use of diuretics.
