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Smoking is a susceptible factor to amyotrophic lateral sclerosis (ALS), but the results are inconsistent and there is a risk of confusing bias.
recently, researchers used the results of a recently published large genome-wide association study and Mendel randomization method to reduce confusion to assess the relationship between smoking and ALS, according to a recent study published in the journal Neurology.
researchers identified two genome-wide association studies that looked at lifetime smoking (n-463003) and former smokers (n-1232091) and used it to define the tool variables for smoking.
whole genome association study of ALS (20,806 cases; 59,804 controls) was used as a result of deficit-weighted Mendel randomization and four other Mendel randomization methods to test whether there was a causal relationship between smoking and ALS.
analysis is bidirectional to assess the reverse causality.
found no strong evidence of a causal or reverse causal link between smoking and ALS.
researchers randomized Mendel using a deficit-weighted method: the ratio of lifetime smoking to ALS (OR) was 0.94 (95% CI 0.74 to 1.19) and p-value was 0.59;
using large sample sizes and sensitivity analyses, the researchers found no evidence that smoking causes ALS.
other smoking conditions, such as current smoking, may be suitable for future Mendel randomized studies.
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