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Ann Rheum Dis: Factors related to death in patients with rheumatism after contracting COVID-19
Time of Update: 2021-06-29
Among patients with rheumatism, COVID-19-related deaths are related to known general factors (advanced age, male, and specific comorbidities) and disease-specific factors (disease activity and specific drugs) .
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Ann Rheum Dis: Non-steroidal anti-inflammatory drugs and the risk of death from COVID-19
Time of Update: 2021-06-29
This study analyzed the correlation between non-steroidal anti-inflammatory drugs (NSAIDs) and death from COVID-19 .
In the multivariate adjustment model, it was observed that compared with not using NSAID, the current risk of COVID-19-related death with NSAID is lower (HR 0.
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NEJM: The role of rituximab vs. mycophenolate mofetil in patients with pemphigus vulgaris
Time of Update: 2021-06-29
In a randomized controlled trial, researchers assigned patients with moderate to severe pemphigus vulgaris in a 1:1 ratio to receive intravenous rituximab (1000 mg each on day 1, 15, 168, and 182) or oral Mycophenolate mofetil (2g per day), in addition, oral glucocorticoids were given on the same tapering schedule in both groups .
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JAHA: Coronary Artery Microvascular Dysfunction in Patients with Systemic Lupus Erythematosus
Time of Update: 2021-06-29
Researchers aim to test that CMD, the abnormal myocardial blood flow reserve (MFR) determined by positron emission tomography-computed tomography, is adjusting non-obstructive Whether atherosclerotic burden and common cardiovascular risk factors are independently related to SLE .
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The latest progress of EULAR gout in 2021
Time of Update: 2021-06-29
Univariate analysis showed that women, osteoarthritis, obesity, heart failure, high blood pressure, chronic kidney disease, and history of gout medication were closely related to the higher risk of recurrence of gout with multiple joint involvement .
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Nat Immunol Song Erwei/Su Shicheng team reveals new strategies to promote T cells into tumors
Time of Update: 2021-06-29
Tumor immunotherapy has won the Nobel Prize in Medicine for 18 years and is currently one of the fastest growing cancer treatments . But currently only about 20-30% of patients benefit, so it is imp
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Johnson & Johnson advertises that Tremfya is effective for patients with psoriatic arthritis who are resistant to Humira
Time of Update: 2021-06-22
Another new AbbVie drug, Rinvoq, is a competitor of Pfizer's Xeljanz, and faces delays in the FDA's evaluation of its psoriatic arthritis .
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Cancer Causes & Control: Obesity may be closely related to the occurrence of prostate cancer
Time of Update: 2021-06-22
Agency scientists conducted a population-based case-control study to investigate the relationship between body size trajectories and the incidence of prostate cancer, and found that abdominal fat may be directly related to the increased risk of prostate cancer in the body .
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Cell's important finding: The presence of type I natural antibodies similar to 2G12 antibodies in the human body may become a new target for HIV-1 vaccines
Time of Update: 2021-06-22
The author only tested the reactivity of this FDG antibody to recombinant HIV-1 Env and SARS-CoV-2 S proteoglycans, but this may exclude other types of polysaccharide forms in the body .
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Target the root cause of complement diseases!
Time of Update: 2021-06-22
The results of another open-label phase II study (NCT03439839) previously published in the "Lancet Hematology" showed that PNH with active hemolysis after receiving standard care therapy (C5 inhibitor Soliris [eculizumab]) In patients, iptacopan as an add-on therapy significantly improved the hematological response and biomarkers of disease activity .
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The 2021 ACR RA Guidelines are released!
Time of Update: 2021-06-22
In June 2021, the American College of Rheumatology (ACR) issued a guideline for the diagnosis and treatment of rheumatoid arthritis (RA), which is the first version of the guideline that was updated 6 years after the 2015 guideline .
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NCB Chen Liang/Yang Pengyuan and others collaborate to reveal the immune memory mechanism of patients recovering from new coronary pneumonia
Time of Update: 2021-06-22
This work uses single-cell ATAC-seq technology and the newly developed single-cell multi-omics Ti-ATAC-seq technology to describe the accessibility of peripheral immune cells to chromatin multi-dimensional atlas in patients recovering from new coronary pneumonia, and to analyze monocytes, The epigenetic mechanism of B cell and T cell immune memory formation .
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Science Immune resident forces at the edge of the brain: myeloid cells in the meninges
Time of Update: 2021-06-22
The following focuses on the interpretation of the first paper: In order to find the source of the marginal myeloid cells of the central nervous system, the authors connected the circulatory systems of UBC-GFP wild-type mice through surgery .
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The limit of human life span is between 120-150 years!
Time of Update: 2021-06-22
[2] Wang MJ, Chen J, Chen F, Liu Q, Sun Y, Yan C, et al.
[2] Wang MJ, Chen J, Chen F, Liu Q, Sun Y, Yan C, et al.
[2] Wang MJ, Chen J, Chen F, Liu Q, Sun Y, Yan C, et al.
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Parkinson is actually related to osteoarthritis!
Time of Update: 2021-06-22
A recent study published in Arthritis Care & Research found that patients with osteoarthritis have an increased risk of Parkinson's disease .
The researchers found that compared with the control group, patients with osteoarthritis had a 41% higher probability of developing Parkinson's disease (adjusted hazard ratio 1.
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Immunity: "harmful" fat may inhibit the body's ability to attack cancer cells by killer T cells
Time of Update: 2021-06-22
Recently, in a research report titled "Uptake of oxidized lipids by the scavenger receptor CD36 promotes lipid peroxidation and dysfunction in CD8+ T cells in tumors" published in the international journal Immunity , scientists from Salk Institute and other institutions Studies have found that the tumor microenvironment contains a large number of oxidized lipid molecules.
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Air pollution caused RA attacks?
Time of Update: 2021-06-22
In the context of this research, Professor Bernard and his collaborators from La Peroni Hospital in France carried out Further study, report the 10-year results of the initial cohort of early RA patients, the ESPOIR cohort, and outcome predictors .
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How does rheumatism happen?
Time of Update: 2021-06-22
Viviana Marzaioli from University College Dublin, National University of Ireland, brought the title "CD209+/CD14+Dendritic Cells are enriched and activated at the site of inflammation and are modulated "by JAK/STAT signalling" report, introduced the pathogenic role of CD209+/CD14+ DC cells in inflammatory arthritis (IA) .
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BCMA target is strong, who can be proud of the arena?
Time of Update: 2021-06-22
At present, CAR-T cell therapy and ADC drugs targeting BCMA have been approved for marketing, and dual-antibody drugs are gaining momentum .
In the future, it is worth thinking about who can be proud of BCMA-targeted double antibodies, ADC and CAR-T .
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Two doses of new crown vaccine against the emergence of a mutated virus in India reduce the risk of hospitalization by 90%...
Time of Update: 2021-06-22
Previously, real-world data released by PHE showed that two doses of the new crown vaccine can produce a high degree of protection against the Delta variant .
