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On June 9, 2021, Nature Cell Biology published an online article titled Single-cell epigenomic landscape of peripheral immune cells reveals establishment of trained immunity in individuals convalescing from COVID-19
.
This work uses single-cell ATAC-seq technology and the newly developed single-cell multi-omics Ti-ATAC-seq technology to describe the accessibility of peripheral immune cells to chromatin multi-dimensional atlas in patients recovering from new coronary pneumonia, and to analyze monocytes, The epigenetic mechanism of B cell and T cell immune memory formation
.
After certain viral infections or vaccination, the human body can induce natural immune cells to show immune memory characteristics similar to those of adaptive immune cells, that is, "trained immunity"
.
The results of the study showed that a large amount of chromatin remodeling occurred in the natural immune cells and adaptive immune cells of patients recovering from new coronary pneumonia
.
The peripheral blood of the recovered patients was enriched with TBET-enriched CD16+ and IRF1-enriched CD14+ monocytes, which were determined to have a trained and activated apparent state
.
In the B-cell lineage analysis, the B-cells of patients with new coronary pneumonia at various stages showed plasma cell-like differentiation characteristics of IgG class switching and antibody secretion
.
In T cell lineage analysis, the researchers created a new single-cell multi-omics Ti-ATAC-seq technology, which can simultaneously obtain the accessible chromatin information, TCR sequence, and cell membrane molecular expression of each T cell at the single cell level.
Level
.
In-depth analysis of CD8+ T cell epigenetic profiles and single-cell TCR clones in patients recovered from new coronary pneumonia revealed that virus-induced effector CD8+ T cells played a key role in the formation of immune memory in the initial control of new coronavirus and memory CD8+ T cells
.
The paper Yang Pengyuan, Mark M Davis and Chen Liang are the co-corresponding authors, and You Maojun is the first author
.
It is worth mentioning that during the same period, Mihai G.
Netea and Yang Li of Radboud University Nijmegen Medical Centre published a review article Immune memory in individuals with COVID-19 in response to this article
.
Original link: https:// Cell Biology Concurrent review article link: https:// ：Eleventh reprinting instructions [Non-original articles] The copyright of this article belongs to the author of the article.
Personal forwarding and sharing are welcome.
Reprinting is prohibited without permission.
The author has all legal rights, and offenders must be investigated
.
.
This work uses single-cell ATAC-seq technology and the newly developed single-cell multi-omics Ti-ATAC-seq technology to describe the accessibility of peripheral immune cells to chromatin multi-dimensional atlas in patients recovering from new coronary pneumonia, and to analyze monocytes, The epigenetic mechanism of B cell and T cell immune memory formation
.
After certain viral infections or vaccination, the human body can induce natural immune cells to show immune memory characteristics similar to those of adaptive immune cells, that is, "trained immunity"
.
The results of the study showed that a large amount of chromatin remodeling occurred in the natural immune cells and adaptive immune cells of patients recovering from new coronary pneumonia
.
The peripheral blood of the recovered patients was enriched with TBET-enriched CD16+ and IRF1-enriched CD14+ monocytes, which were determined to have a trained and activated apparent state
.
In the B-cell lineage analysis, the B-cells of patients with new coronary pneumonia at various stages showed plasma cell-like differentiation characteristics of IgG class switching and antibody secretion
.
In T cell lineage analysis, the researchers created a new single-cell multi-omics Ti-ATAC-seq technology, which can simultaneously obtain the accessible chromatin information, TCR sequence, and cell membrane molecular expression of each T cell at the single cell level.
Level
.
In-depth analysis of CD8+ T cell epigenetic profiles and single-cell TCR clones in patients recovered from new coronary pneumonia revealed that virus-induced effector CD8+ T cells played a key role in the formation of immune memory in the initial control of new coronavirus and memory CD8+ T cells
.
The paper Yang Pengyuan, Mark M Davis and Chen Liang are the co-corresponding authors, and You Maojun is the first author
.
It is worth mentioning that during the same period, Mihai G.
Netea and Yang Li of Radboud University Nijmegen Medical Centre published a review article Immune memory in individuals with COVID-19 in response to this article
.
Original link: https:// Cell Biology Concurrent review article link: https:// ：Eleventh reprinting instructions [Non-original articles] The copyright of this article belongs to the author of the article.
Personal forwarding and sharing are welcome.
Reprinting is prohibited without permission.
The author has all legal rights, and offenders must be investigated
.
