-
"If you don't eat it, you won't be sick." The latest research shows that maintaining hygiene and exposure to microorganisms are also beneficial to immunity!
Time of Update: 2021-08-03
In this paper published in the Journal of Allergy and Clinical Immunology, the researchers pointed out four important reasons that overturned this general theory and concluded that keeping clean and hygienic It is not inconsistent with the microbes in the environment, and it is beneficial to the immune system to a certain extent .
-
Nature: How does the BNT162b2 mRNA vaccine perform in the population?
Time of Update: 2021-08-03
The results showed that after vaccination, the subjects produced powerful neutralizing antibodies (nAbs) against the Wuhan mother strain of the new crown , and to a lesser extent, neutralizing antibodies against the B.
-
Ann Rheum Dis: Tofacitinib's Phase III Trial Results for Ankylosing Spondylitis
Time of Update: 2021-08-03
This is a phase III, randomized, double-blind, placebo-controlled study that enrolls patients with active AS aged ≥18 years who meet the modified New York criteria and have poor efficacy with more than two non-steroidal drugs .
-
J Allergy Clin Immunol: Efficacy and safety of omalizumab in the treatment of nasal polyposis: 2 randomized phase 3 trials
Time of Update: 2021-08-03
Secondary endpoints included changes in the Middle Nose Outcome Test-22 (SNOT-22) score from baseline to Week 24, the University of Pennsylvania Odor Recognition Test, smell, postnasal drops, runny nose, and adverse events .
-
Ineffective against mutant strains, Eli Lilly’s double antibody therapy was stopped
Time of Update: 2021-08-03
[Text/Observer Net Tao Meng, Zhou Yi, Editor/Zhou Yuanfang]Because of its ineffectiveness against some mutant strains, Eli Lilly’s "dual antibody therapy" was temporarily suspended in the United States .
In vitro studies have shown that this "dual antibody therapy" is currently unable to provide effective treatment for new variant strains .
-
Front Immunol: Vitamin D research reveals its impact on the immune system
Time of Update: 2021-08-02
Researchers have found that it also affects the key cell immunity of the immune system - dendritic cells (DC) , which are a special sentinel cell that connects natural immunity and adaptive immune response, and plays a role in the formation of adaptive immune response.
-
Nat Commun: Lasp1: A potential therapeutic target for inflammatory arthritis
Time of Update: 2021-08-01
Lasp1 is an epigenomic co-modified region in chronic inflammatory arthritis, which can functionally bind to the Cadherin-11/β-Catenin complex in the zipper-like cell junction .
Lasp1 is an epigenomic co-modified region in chronic inflammatory arthritis, which can functionally bind to the Cadherin-11/β-Catenin complex in the zipper-like cell junction .
-
Amgen acquires Teneobio for US$2.5 billion to consolidate its leading position in new antibody drugs
Time of Update: 2021-07-30
Amgen will pay an upfront payment of US$900 million to acquire Teneobio, a biotechnology company with technology for the discovery and development of antibody drugs .
Amgen will pay an upfront payment of US$900 million to acquire Teneobio, a biotechnology company with technology for the discovery and development of antibody drugs .
-
JAHA: Blood pressure variability may be directly related to the increased risk of dementia in the body. The impact on men is particularly serious!
Time of Update: 2021-07-28
Recently, in a research report entitled "Long-Term Blood Pressure Variability and Risk of Cognitive Decline and Dementia Among Older Adults" published in the International Journal of the American Heart Association , scientists from the University of Iowa and other institutions Studies have found that the variability of hypertension in the elderly (especially men) may be closely related to the increased risk of dementia and the decline in cognitive function .
-
Gather the safety of JAK inhibitors!
Time of Update: 2021-07-28
News on July 22, 2021 // - Pfizer (Pfizer) announced today that the US Food and Drug Administration ( the FDA ) has informed the company will not be (PDUFA) target date "Prescription Drug User Fee A
-
New medicine for dermatomyositis!
Time of Update: 2021-07-28
This prospective, double-blind, placebo-controlled Phase 3 clinical trial enrolled 95 patients in 36 clinical centers around the world (including 17 in the United States) and is the largest study evaluating IVIg as a treatment option for dermatomyositis .
"FDA The ProDerm clinical trial included an initial 16-week, double-blind, placebo-controlled period.
-
Thorax: Peripheral blood leukocyte telomere length is associated with the progression of systemic sclerosis interstitial lung disease
Time of Update: 2021-07-28
Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis .
com/content/early/2021/07/15/thoraxjnl-2020 -215918Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis in this message
-
Ann Rheum Dis: The impact of the COVID-19 pandemic on the mortality of patients with inflammatory joint disease
Time of Update: 2021-07-28
This study is to evaluate the inflammatory joint disease patients (IJDs) anti-rheumatic therapy COVID-19 severe infections all-cause absolute and relative risk of death .
-
Arthritis Rheumatol: The relationship between MRI-assessed subchondral cysts and knee joint pain and osteoarthritis
Time of Update: 2021-07-28
MRI-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: data from the Multicentre Osteoarthritis Study .
41917MRI-Assessed Subchondral Cysts and Incident Knee Pain and Knee Osteoarthritis: data from the Multicentre Osteoarthritis Study in this message
-
Ann Rheum Dis: Uric acid control prevents gout attacks in asymptomatic hyperuricemia patients
Time of Update: 2021-07-27
Serum uric acid control for prevention of gout flare in patients with asymptomatic hyperuricaemia: a retrospective cohort study of health insurance claims and medical check-up data in Japan .
-
Can rheumatism patients get vaccinated?
Time of Update: 2021-06-30
*Only for medical professionals to read and use hormones, can not be vaccinated? According to unofficial statistics that are not rigorous, the public's demand for different vaccines has increased in
-
How to diagnose and treat systemic sclerosis with interstitial lung disease?
Time of Update: 2021-06-30
Figure 11: Rituximab treatment of ILD can increase FVC% 4 Tocilizumab A subcutaneous injection of tocilizumab in the treatment of SSc safety and effectiveness Phase 2, randomized controlled study showed: compared with placebo group , Tocilizumab has nothing to do with the improvement of SSc skin thickening, but fewer patients predicted a decrease in FVC% at 48 weeks of treatment with tocilizumab (p=0.
-
Discipline collision Respiratory, rheumatism majors reveal the secret of progressive fibrotic interstitial lung disease
Time of Update: 2021-06-30
In terms of drug selection, the results of the INBUILD study confirmed the application value of nintedanib in patients with PF-ILD, and therefore became the only one currently receiving the indication of "chronic fibrotic interstitial lung disease with a progressive phenotype" Drugs .
-
EULAR update: GRAPPA releases the latest recommendations for PsA treatment!
Time of Update: 2021-06-30
This principle points out that recommendations are based on the latest data of PsA assessment and treatment methods, and they will help doctors and patients to make joint decisions in clinical practice .
-
How to improve the diagnosis rate of lupus?
Time of Update: 2021-06-30
Anti-Sm antibodies (Anti-Sm antibodies) are often seen in the diagnosis of systemic lupus erythematosus (SLE), and they were first named because they were discovered in a lupus patient named Smith in 1966 .
In terms of detection methods, the commonly used detection methods for anti-Sm antibodies include convective immunoelectrophoresis, western blotting, and enzyme-linked immunosorbent assay .
