Front Immunol: Vitamin D research reveals its impact on the immune system

Vitamin D is produced by the body's response to sunlight and is often praised for its health benefits
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Researchers have found that it also affects the key cells of the immune system - dendritic cells (DC) , which are a special sentinel cell that connects natural immunity and adaptive immune response, and plays a key role in the formation of adaptive immune response.

Vitamin D is produced by the body's response to sunlight and is often praised for its health benefits

The team at the University of Edinburgh studied the vitamin D affect a mechanism in the body's immune system - dendritic cells to activate T capacity of the cells

In healthy people, T cells play a vital role in helping fight infection
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However, for people with autoimmune diseases, they begin to attack their own tissues

In healthy people, T cells play a vital role in helping fight infection

By studying cells from mice and humans, the researchers found that vitamin D caused dendritic cells to produce more molecular CD 31 on their surface , which hindered the activation of T cells

Down-regulate the expression of CD 31 in VitD bone marrow-derived DC (BMDC)

Down-regulate the expression of CD 31 in VitD bone marrow-derived DC (BMDC)

Experiments show that CD 31 can shorten the interaction time of BMDC-T cells
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This is an essential part of the activation process - the resulting immune response is greatly reduced

Experiments show that CD 31 can shorten the interaction time of BMDC-T cells

The researchers said the findings reveal how vitamin D deficiency regulates the immune system and affects susceptibility to autoimmune diseases

Low vitamin D levels have long been considered an important risk factor for the development of several autoimmune diseases.

Article reference: Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John DM Campbell, Daniel Y.

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