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Thorax: Peripheral blood leukocyte telomere length is associated with the progression of systemic sclerosis interstitial lung disease

 Last Update: 2021-07-28
 Source: Internet
 Author: User

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Peripheral blood leukocyte telomere length (PBL-TL) is related to the prognosis of patients with idiopathic pulmonary fibrosis
.

Whether PBL-TL is related to the progression of systemic sclerosis-related interstitial lung disease (SSc-ILD) is not yet clear

Recently, a research article was published in Thorax, an authoritative journal in the field of thoracic diseases.
This retrospective observational cohort study used data from 213 SSc patients collected prospectively from the University of California, San Francisco (UCSF) Scleroderma Center for analysis
.

PBL-TL is determined by quantitative PCR on DNA isolated from peripheral blood

Researchers used a generalized linear mixed model to evaluate the association between PBL-TL and pulmonary function test trends in SSc-ILD patients through longitudinal analysis
.

The results of these studies were verified in a cohort of 61 SSc-ILD patients registered in the Stanford University Scleroderma Center database

The researchers found that the PBL-TL of UCSFSSc patients with ILD was shorter than that of patients without ILD (6554±671 (base pairs, bp) vs.
6782±698bp, p=0.
01)
.

The shorter PBL-TL is associated with ILD (the adjusted OR after TL reduction by 1000 bp is 2.

Thus, these results indicate that telomere dysfunction may be related to the progression of SSc-ILD, and PBL-TL measurement may help stratify the risk of progression of SSc-ILD
.

These results indicate that telomere dysfunction may be related to the progression of SSc-ILD, and PBL-TL measurement may help stratify the risk of progression of SSc-ILD
.

Original source:

Shuo Liu,et al.

Peripheral blood leucocyte telomere length is associated with progression of interstitial lung disease in systemic sclerosis in this message

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