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Gastroenterology: Study of the mechanism by which Bacillus deformation induces inflammation in patients with Crohn's disease.
Time of Update: 2020-10-28
The genus Proteus spp, which belongs to the Gloenic negative and anaerobic bacillus, is associated with a recurrence after intestinal excision in patients with Crohn's disease (CD).
Proteus spp played an important role in the pathology of patients with Crohn's disease by inducing inflammation.
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UEGW 2020: Replacing other types of biologics or other anti-TNF antibodies is the most effective strategy against pharmaceutical antibodies.
Time of Update: 2020-10-27
At the 2020 European Digestive Disease Week (UEGW) online meeting, a study showed that in patients with inflammatory bowel disease (IBD), anti-tumor necrosis factor (TNF) antibodies are treated with anti-drug-resistant antibodies (ADA) and then switched to another TNF inhibitor or another type of biologic agent, which is the most effective way to help patients alleviate the disease.
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Nature sub-journal interpretation! Scientists hope to use robots to help make colonoscopy easier!
Time of Update: 2020-10-27
26, 2020 /PRY/ -- The University of Leeds has made a major breakthrough in the development of semi-automatic colonoscopy research by using robots to guide medical devices into the human body in a recent study published in the international journal Nature Machine Intelligence entitled "Intelligence Enabling of the future of colonoscopy with intelligent and autonomous magnetic fields".
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NEJM: Drying conjunctivitis in patients with dry syndrome - case reported.
Time of Update: 2020-10-27
The patient's vision in each eye was 20/25, and a fissure lamp examination found that the conjunctivitis was congestive, the corneal epithelirsis and the corneal endothragm folding were consistent with dry corneal conjunctivitis (as shown in Figures A and B).
the patient was diagnosed with dry syndrome, and local treatments for eye symptoms included cyclosporine A and artificial tear fluid.
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Cell sub-journal interpretation! Uncover the molecular processes of hypoxia that damage brain health!
Time of Update: 2020-10-27
Then the researchers discovered an additional reaction that could impair the function of stem cells in the brain, which was not previously known to the researchers, suggesting that hypoxia-reactive proteins may have evolved to promote cell survival in all tissues of the body in oxygen-deprived conditions, but this powerful effect can also have abnormal consequences such as interfering with cell function.
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Can humans really achieve COVID-19 zero infection? This may take quite some time!
Time of Update: 2020-10-27
There are currently more than 200 SARS-CoV-2 vaccines under development, but if there is a vaccine that can completely eliminate COVID-19, the threshold may be a little higher, and any vaccine needs to be very effective in preventing disease and blocking its spread in the population.
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Sci Immunol: Scientists have discovered new treatments that can effectively prevent and treat viral infections such as rotiss viruses.
Time of Update: 2020-10-24
11, 2020 // -- In a recent study published in the international journal Science Immunology, scientists from Georgia State University and other institutions found that combining two substances secreted
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HGT: Scientists hope to use mRNA therapy or CRISPR gene editing techniques to treat cystic fibrosis.
Time of Update: 2020-10-24
James Dahlman says that the treatment of cystic fibrosis by transporting mRNA to encode CFTR may work in any cystic fibrosis patient's body, which does not seem to depend on the mutations carried in the patient's body, while another potential treatment is to use mRNA to encode nucleases associated with gRNA, such as CRISPR-Cas9, and use it to edit DNA in targeted cells.
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Genome Med: Single-cell RNA sequencing techniques that can reveal the properties of individual cells in pancreatic tumors are expected to help develop individual pancreatic cancer therapies.
Time of Update: 2020-10-24
Dr. Haiyong Han, an researcher, said single-cell transcriptomic analysis could provide important clinical insights into single-cell subgroups, as well as new clues to the development of targeted therapies and new immunotherapy, understanding the diversity and complexity of pancreatic catheterized adenocarcinoma, as well as the characteristics of a single tumor intermediate chamber, or helping scientists identify specific interventions and develop new treatments and interventions for patients with malignant cancer.
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Cell: "International Alliance for the Selection of New Antigens for Tumors" unlocks new individualized cancer therapies by improving the prediction of new antigens for tumors to reveal key parameters of tumor-based immunogenicity.
Time of Update: 2020-10-24
Photo Source: Parker Institute for Cancer Immunotherapy In a recent study published in the international journal Cell, scientists from the Parker Institute for Cancer Immunotherapy and others found special parameters that could help predict which new antigens could better stimulate the body's anti-cancer effectiveness, and the results could help develop a new generation of highly effective individualized cancer immunotherapy.
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AstraZenecon's long-acting new coronary antibody begins phase III clinically.
Time of Update: 2020-10-24
especially the antibody mixtures REN-CoV2 and LY-CoV555, because they contain two antibodies binding to different bits of S-protein, it can more effectively avoid the escape of virus mutations, showing a more credible reduction of viral load efficacy.
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New Crown Outbreak: 36.8 million cases! Johnson and Johnson and the European Commission reached a COVID-19 vaccine supply agreement: 400 million doses to EU member states!
Time of Update: 2020-10-24
the agreement, Johnson and Johnson's Janssen Pharmaceuticals will supply 200 million doses of COVID-19 vaccine to EU member states after the candidate vaccine is approved or authorized by regulators.
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Science: Revealing the antibody mixture REN-COV2 promises to prevent and treat new coronary pneumonia.
Time of Update: 2020-10-24
results were published online October 9, 2020 in the journal Science under the title "REGN-COV2 antibodies prevent and treat SARS-CoV-2 infect in rhesus macaques and hamsters".
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JEM deep interpretation! Why can a small mutation have a very large effect on the properties of T cells?
Time of Update: 2020-10-23
October 13, 2020 // -- T-cells play a key role in the functioning of the human immune system, effectively distinguishing diseases or foreign bodies from the body's own healthy tissues with high accura
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Sci Rep: New research finds! Many mammals are more susceptible to SARS-CoV-2 infection, while fish, birds and reptiles are less susceptible to infection!
Time of Update: 2020-10-23
Photo Source: NIAID researchers have revealed the molecular mechanism by which prickly proteins from SARS-CoV-2 interact with ACE2 proteins on the surface of host cells when an infection occurs, and in this study, researchers investigated the presence of mutations in ACE2 proteins on the surface of 215 different animal host cells that make ACE2 proteins different from ACE2 proteins in human hosts, which may reduce the stability of the binding complex between viral proteins and host proteins.
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The world's first long-acting C5 inhibitor! Ultomiris 100mg/mL high concentration preparations are FDA approved, significantly reducing treatment time!
Time of Update: 2020-10-23
, the company announced that the U.S. Food and Drug Administration (FDA) has approved Ultomiris (ravulizumab-cwvz) 100mg/mL preparation: (1) therapeutic thymoglobin Urine (PNH) adult patients; (2) treatment of atypical hemolytic uremic syndrome (aHUS) in adults and children (≥1 month) patients to inhibit complement-mediated thrombosis microvascular disease (TMA).
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Nat Commun: How can I effectively improve the efficiency of cell therapy? The scientists give you a trick!
Time of Update: 2020-10-23
Nevertheless, many obstacles can still hinder the effectiveness of immunotherapy because of the T-cell tolerance mechanism, which causes the body to produce a state that fails against specific antigen immune responses, and researcher Lebel said that in this study, we focused on understanding the mechanisms by which T-cells produce tolerance, designed to reveal the molecular mechanisms by which specific T-cells are not effective in attacking diseased cells.
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Process Res: Exercise may be effective in reducing the risk of heart disease in diabetics.
Time of Update: 2020-10-23
12, 2020 // -- In a recent study published in the international journal Circust Research, scientists from the University of Otago and others revealed how exercise can help reduce the risk of heart disease caused by diabetes, suggesting that exercise can induce the release of microRNAs in the heart, which can help increase protein production and help improve heart structure and function.
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Cell Rep: Key viral factors affect immunity in COVID19 patients.
Time of Update: 2020-10-23
team at the Institute of Medical Sciences (IMSUT) at the University of Tokyo aimed to identify the viral factors that determine immune activation after SARS-CoV-2 infection and found that the gene ORF3b, encoded by SARS-CoV-2, was an effective IFN antagonist.
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Commun Biol: New results! Scientists have developed an app called Genopo that can be used to fully analyze the genomic properties of coronavirus.
Time of Update: 2020-10-23
In addition, so far, genomic analysis has required processing power from high-end server computers or cloud services, and researchers are working to change that, and in order to achieve real-time genome sequencing and analysis in place, without large laboratory equipment, researchers have developed a new app that can perform bio-information workflows on smartphones that download nano-hole sequencing databases.