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New Crown Vaccine Express! WHO adds AstraZeneta AZD1222 to its list of emergency uses: routine refrigeration, 2-pin immunization, no profitable global supply!
Time of Update: 2021-02-26
recently, AstraZeneca announced that its adenovirus vaccine COVID-19 Vaccine AstraZeneca (formerly known as AZD1222), developed with Oxford University, has been placed on the Emergency Use List (EUL) by the World Health Organization (WHO) for active immunization of people aged 18 and over, including those aged 65 and over, to prevent COVID-19.
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BMJ: Milk is the most common cause of fatal allergic reactions in children in the UK
Time of Update: 2021-02-26
The hospitalization rate for people with food allergies increased from an average of 1.23 cases per 100,000 people per year in 1998 to 4.04 cases per year in 2018, an increase of 5.7 per cent per year, with the fastest increase in hospitalizations among children under 15 years of age, from an average of 2.1 per 100,000 population per year to 9.2 (an annual growth rate of 6.6 per cent).
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Br J Cancer: Research on the anti-tumor efficacy of immuno-triple therapy
Time of Update: 2021-02-26
, the study aims to compare intracular dynamics differences in the subsystress of key immune cells receiving a range of immunotherapy treatments.
results showed that HPV E7 long peptides and PIC were given in the tumor and the systemic anti-PD-1 mAb treatment was carried out to achieve maximum anti-tumor efficacy.
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NEJM: Avacopan is used to treat ANCA-related vasculitis
Time of Update: 2021-02-26
the researchers conducted a Phase 3 randomized trial (ADVOCATE) that compared the role of avacopan and the d diminishing number of Ponieson in patients with ANCA-related vasculitis who were treated with immunosuppressive drugs at the same time.
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Vaccination 1 shot to prevent COVID-19! Johnson and Johnson single dose of new crown vaccine EU application for market: prevention of moderate to severe COVID-19, total efficiency 66%!
Time of Update: 2021-02-26
February 18, 2021 // -- Johnson and Johnson (JNJ) recently announced that its Jansen-Cilag International Corporation has submitted a conditional marketing authorization application (MAA) to the European Medicines Agency (EMA) seeking approval for its single dose of Jassen COVID-19 vaccine.
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JAHA: Epidemiological characteristics of heart failure, room conduction block and room titration in patients with nodule disease
Time of Update: 2021-02-24
researchers identified the risk of nodule disease for heart failure, room conduction block, and roomic titration, and linked it to the Social Security Death Index to determine overall mortality.
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JCI: Let immune cells discover viruses! Scientists have developed a new treatment that targets the killing of human cytocytovirus!
Time of Update: 2021-02-24
20, 2021 // -- In a recent study published in the international journal Journal of Clinical Investigation, scientists from cardiff University and other institutions found a special way to target a common viral virus (human cytocytovirus), which affects the health of one in 200 newborns in the UK, but currently has very limited treatment.
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Lilly and Rigel have authorized a $960 million partnership to develop RIPK1 inhibitors to treat autoimmune and inflammatory diseases!
Time of Update: 2021-02-23
19, 2021 // -- Eli Lilly and Rigel Pharmaceuticals have jointly announced that they have reached a global exclusive license agreement and strategic partnership to jointly develop and commercialize R552 for all adaptations, including autoimmune and inflammatory diseases.
cooperation agreement, Lilly will also lead the clinical development of brain-penetrating RIPK1 inhibitors in all central nervous system (CNS) diseases.
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Special dermatitis (AD) innovative therapy! Concorde Kirin pioneered THEX40 targeted single anti-KHK4083 Phase II clinical success!
Time of Update: 2021-02-23
February 19, 2021 // -- Kyowa Kirin, a Japanese pharmaceutical company, recently announced that phase 2 studies evaluating the antibody drug KHK4083 to treat adult patients with moderate to severe endexual dermatitis (AD) have reached the main endpoint.
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The study revealed the mechanism by which PDK1, a protein kinase, regulates Tfh cell differentiation
Time of Update: 2021-02-23
this paper, based on PY3K downstream protein kinase PDK1 (serine/threonine kinase 3-phosphoinositide-dependent kin proteinase 1) condition knockout mice, combined with a variety of genetically engineered mouse models of the immune response analysis, expounded the function of PDK1 in the TFH cell differentiation process and related molecular mechanisms, and further improved the PY3K path in Tfh cell differentiation.
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BCMA CAR-T Cell Therapy! Johnson/Nanjing Legend cilta-cel awarded an accelerated assessment by the European Union: Treatment of multiple myeloma!
Time of Update: 2021-02-16
February 02, 2021 // -- Johnson and Johnson (JNJ)'s Janssen Pharmaceuticals recently announced that the European Medicines Agency (EMA) Commission on Human Pharmaceutical Products (CHMP) will accelerate the evaluation of the marketing authorization application (MAA) for BCM CAR-T cell therapy cilta-tag autoneucel (cilta-cel), formerly known as JNJ-4528/LCAR-B38M.
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Respiratory Res: Hyalurallic acid helps treat chronic lung disease
Time of Update: 2021-02-16
years ago, Dr. Stavros Garantziotis, medical director of clinical research at the National Institutes of Health (NIH) and co-senior author, said exposure to pollution causes hyalurinoic acid in the lungs to break down into smaller fragments.
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Cancer Res: Study reveals new treatment for melanoma
Time of Update: 2021-02-16
factors that actively contribute to the progression of melanoma include MET, a tyrosine kinase complex that is over-expressed in melanoma and is associated with tumor growth, invasion and drug resistance.
, the experimental model treated with the drug has been significantly delayed or has not progressed to an invasive disease.
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New drug for multiple sclerosis! Plegridy (polyglycol interferon β-1a) intramyal injection program approved by the FDA!
Time of Update: 2021-02-16
February 02, 2021 // -- Biogen recently announced that the U.S. Food and Drug Administration (FDA) has approved Plegridy (polyglycolin interferon β-1a) as a new intramuscular (IM) injection pathway for the treatment of patients with multiple sclerosis (RMS).
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Nature: Significant progress! AIM2 is important for the normal functioning of regulatory T cells and plays a key role in reducing autoimmune diseases
Time of Update: 2021-02-16
Now, in a new study, a team led by Dr. Jenny Ting, a professor of genetics at the University of North Carolina School of Medicine, and Dr. Yisong Wan, a professor of microbiology and immunology, has found that AIM2 is important for the normal functioning of regulatory T-cells and plays a key role in reducing autoimmune diseases.
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Nat Commun: How do "weak" and "strong" β cells bind to each other to strengthen the body's resistance to type 2 diabetes?
Time of Update: 2021-02-15
researcher David Hodson said the study showed that by analyzing the levels of PDX1 and MAFA proteins to clarify β cell maturity differences, it is β necessary for proper insulin release; Photo Source: CC0 Public Domain restores islet function in metabolic stress conditions (excessive sugars and fats in the diet) by correcting the balance between immature and mature islet β cells, while also providing evidence that "weak" and "strong β cells may promote proper islet function and release of insulin.
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Expert Review of Vaccines: Viral vaccines are safe for children with immunodeficiency
Time of Update: 2021-02-15
February 3, 2020 //--- According to a study review, inactivated and detoxifying live vaccines generally produce adequate immune responses and can be safely used in children with autoimmune diseases treated for all but the most effective immunosuppressants.
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J Neuroinflam: New drug can relieve inflammatory response to multiple sclerosis
Time of Update: 2021-02-15
(Photo: www.pixabay.com) has previously developed an amino butterfly therapy that targets folic acid, which targets folic acid subjects on phagocytosis cells, which has been shown to shut down active inflammation in multiple disease models, but this latest study is the first to demonstrate the efficacy of injection-induced MS chronic carrying models in the brains of rats.
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Sci Rep: Scientists have identified a new potential target protein, RPS-12, that could help develop new cancer therapies
Time of Update: 2021-02-15
February 4, 2021 // -- In a recent study published in the international journal Scientific Reports, scientists from the Russian Federal University of the Far East and other institutions used the devel
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Sci Adv: Multiple intake of saturated fatty acids can help relieve pancreatitis
Time of Update: 2021-02-15
the new study, researchers looked closely at the link between pancreatitis and fat intake (saturated or unsaturated).
previous studies have shown that people are healthier if they reduce their intake of saturated fat and eat more unsaturated fat.
