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Shadow - low white and m3
Time of Update: 2022-10-31
Push the film for reexamination, a type of cells can be seen under the microscope: large cell body, butterfly shape visible nucleus, fine chromatin, more cell quality, increased granules, visible internal and external plasma, and some cells can see Auer bodies.
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BJH: Trends in survival and cure after allogeneic hematopoietic cell transplantation in acute myeloid leukemia, 2000-2020: a Danish population-based cohort study
Time of Update: 2022-10-31
Figure 1: Estimated two-year overall survival (OS) after allogeneic hematopoietic cell transplantation (HCT) for acute myeloid leukemia (AML) based on transplant calendar yearOriginal source:Gjaerde LK, Jakobsen LH, Juhl-Christensen C, Olesen G, Petruskevicius I, Severinsen MT, Marcher CW, Theilgaard-Mönch K, Andersen NS, Friis LS, Kornblit B, Petersen SL, Schjødt I, Sengeløv H.
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Endothelin-1 gene polymorphisms (G8002A) and endothelial monocyte-activated peptide II: role in vascular dysfunction in pediatric β-thalassemia patients
Time of Update: 2022-10-31
Research Objectives:To assess the ET-1 gene polymorphism (G8002A) in pediatric patients with β-thalassaemia (β-TM) as a potential genetic marker for vascular dysfunction and its possible relationship with EMAP-II, oxidative stress, and vascular complications.
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Long-term antibiotic use or persistent diarrhea negatively affect vitamin K1 levels in Egyptian infants aged 2-24 weeks
Time of Update: 2022-10-31
Conclusions:VKDB is a preventable, life-threatening cause of bleeding that remains a major health problem in Egyptian infants, persistent diarrhoea and antibiotic abuse are widespread, necessitating a booster dose of VK for those at high risk.
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Medicina: 1 case of pancytopenia with aplastic anemia/paroxysmal nocturnal hemoglobinuria undetected due to SARS-CoV-2 infection: case report
Time of Update: 2022-10-31
During an acute SARS-CoV-2 infection, a 78-year-old woman presents to the emergency department with severe pancytopenia and is diagnosed with aplastic anemia with episodic nocturnal hemoglobinuria (AA/PNH).
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JCO: BCMA-targeting cilta-cel in relapsed/refractory multiple myeloma in China Phase II outcome, 18-month OS rate of 78.7%
Time of Update: 2022-10-31
For multiple myeloma (MM), new drugs have sprung up in the past two decades, different proteasome inhibitors, immunomodulators, CD38 monoclonal antibodies, XPO1 inhibitors, etc. have been listed in Ch
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Nat Rev Immunol: cytokine release syndrome and associated neurotoxicity in tumor immunotherapy
Time of Update: 2022-10-31
Two major toxicities of CAR T cell production were not shown in early mouse models, but eventually occurred in clinical trials, namely cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS; Often referred to as neurotoxicity).
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Curr Med SCI: a novel immunosuppressive therapy for children with very severe aplastic anemia with autoantibodies
Time of Update: 2022-10-31
Currently, many patients with very severe aplastic anemia (VSAA) are unable to receive hematopoietic stem cell transplantation (HSCT) or standard immunosuppressive therapy (IST) due to the high cost of treatment, and there is a shortage of sibling donors and a lack of resources to support HSCT.
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Cancers: Research status of dual-target CAR-T cell therapy
Time of Update: 2022-10-31
Currently, in preclinical models and clinical trials of hematological malignancies, there are at least three combinations of antigens for dual-target CAR-T cell therapy: CD19/CD20, CD19/CD22, and BCMA/CD38.
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Environ Sci Technol: The higher the cotton content, the greater the harm! The school uniform material can enter the bloodstream, but it cannot be drained but there is permanent damage!
Time of Update: 2022-10-31
Figure 3 Research results (Source: [2])The researchers purchased large quantities of school uniforms, outdoor clothing, and infant textiles in the United States and Canada to determine the total fluorine content and PFAS category and content in the samples.
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【Probe 24H】New study finds that AIDS is expected to be cured! The proportion of adverse drug reactions in the elderly population continues to rise
Time of Update: 2022-10-31
New study finds that AIDS is promising; The proportion of adverse drug reactions in the elderly population continued to rise; Ferring Pharma Publishes Seven Analysis Reports for RBX2660.
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In reality, CD38 monoclonal antibody can still benefit RRMM patients in the real world
Time of Update: 2022-10-26
Multiple myeloma (MM) is a malignant disease with abnormal proliferation of clonal plasma cells, with the second highest annual incidence among hematological tumors1, and is still incurable, almost al
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2022 SHS| Professor Fu Jianhong: Frontier progress in the diagnosis and treatment of blood disease infection and severe disease
Time of Update: 2022-10-26
Combined with years of experience in the diagnosis and treatment of hematology specialist ICUs and the newly issued "Chinese Expert Consensus on the Management of Giant Cell Infection in Allogeneic Hematopoietic Stem Cell Transplantation Patients (2022 Edition)", CMV prophylaxis or preemptive treatment can significantly improve the prognosis of high-risk patients, such as haploid, patients with ATG pretreatment or severe graft-versus-host disease (GVHD).
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Micro Classroom No. 14 Prof. Min Yang: Early diagnosis of AL amyloidosis
Time of Update: 2022-10-25
Fig. 2 Effect of bone marrow plasma cell infiltration level on PFS and OSIn addition to bone marrow plasma cells, serum free light chain (sFLC) testing is also important for the diagnosis and prognosis of patients with AL amyloidosis.
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Lancet Haematol: Iberdomide treatment of severe pretreatment of multiple myeloma results, cornerstone of future new treatments?
Time of Update: 2022-10-25
Treatment for multiple myeloma has improved significantly over the past two decades, bringing overall survival to unprecedented levels, but a significant proportion of patients still relapse, requirin
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How to improve the quality of life of children after HSCT and protect the future of children in multiple dimensions
Time of Update: 2022-10-25
*This article is only for providing scientific information to medical professionals and does not represent the views of this platformHSCT is a treatment method in which children receive ultra-large doses of radiotherapy or chemotherapy to remove tumor cells and abnormal clonal cells from the body, and then infuse hematopoietic stem cells collected from themselves or others to rebuild normal hematopoietic and immune function [3].
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Hemasphere: KPd regimen is safe and effective as second-line treatment for lenalidomide-refractory multiple myeloma
Time of Update: 2022-10-25
Lenalidomide refractory multiple myelomaFor multiple myeloma, first-line high-dose melphalamide pretreatment combined with ASCT and subsequent naldomide maintenance therapy is the standard of care, an
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A case of abnormally elevated white blood cells triggers thinking
Time of Update: 2022-10-25
Case studiesBased on the patient's history, peritoneal effusion may be due to decompensation of cirrhosis, hypoproteinemia, and portal hypertension; The patient himself has chânybronchiolitis with emphysema, which may cause elevated white blood cells in peripheral circulation, but not to a large extent.
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The diagnostic history of a case of T-cell large granular lymphocytic leukemia
Time of Update: 2022-10-25
Hemomyeloid image: the proportion of T lymphocytes in the bone marrow is increased, combined with flow cytometry immunophenotyping can not exclude T-cell lymphoma (large granular T lymphocytic leukemia), but please rule out reactive changes first, please combine clinical, bone marrow smear and other examinations, and do TCR rearrangement examination.
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Am J Hematol: Diagnosis, Risk Stratification and Treatment of Hodgkin Lymphoma (2023 Update)
Time of Update: 2022-10-25
The RAPID study, which randomised non-large massed early-stage patients with intermediate PET negative (score 1 or 2) after 3 cycles of ABVD to either the 30 Gy IFRT group or no further treatment, found no significant difference in 3-year PFS and OS between the two groups, but a trend towards poor disease control in patients who did not receive radiotherapy, and the difference became statistically significant (97.
