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Br J Cancer: Whole genome analysis reveals the role of statins in colorectal cancer
Time of Update: 2021-03-30
All in all, the results of the study revealed that statins can induce BMP-specific activation of PTEN and inhibit the PI3K/Akt/mTOR signal transduction pathway in CRC.
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Br J Cancer: LIMCH1 and HLA-DQB1 are potential markers of invasive cervical cancer
Time of Update: 2021-03-30
1038/s41416-021-01305-0">A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease .
1038/s41416-021-01305-0">A 10-gene prognostic signature points to LIMCH1 and HLA-DQB1 as important players in aggressive cervical cancer disease Leave a message here
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Nature: Liver cancer patients with underlying liver disease do not respond to immunotherapy
Time of Update: 2021-03-30
March 26, 2021 //---According to a recent study published in the journal Nature, immunotherapy is not only significantly ineffective for liver cancer patients who had previously suffered from non-alcoholic steatohepatitis (NASH), but it actually seems Promote the growth of tumors.
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Br J Cancer: Autoimmunity induced by immune checkpoint blocking therapy is related to the prognosis of metastatic melanoma and a unique T cell expression profile
Time of Update: 2021-03-30
All in all, the results of this study show that the early occurrence of irAE after ICB treatment is related to the better survival of MM patients.
The early occurrence of irAE after ICB treatment is related to the better survival of MM patients.
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Br J Cancer: Olaparib combined with hemi-thoracic radiotherapy to improve the therapeutic index of lung cancer
Time of Update: 2021-03-30
The purpose of this study is to explore the therapeutic index of olaparib combined with hemi-thoracic radiotherapy in a mouse lung cancer model induced by urethane.
The purpose of this study is to explore the therapeutic index of olaparib combined with hemi-thoracic radiotherapy in a mouse lung cancer model induced by urethane.
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Br J Cancer: A few cups of coffee or tea a day can improve the survival rate of breast cancer patients
Time of Update: 2021-03-30
The results showed that increased coffee intake after diagnosis was associated with a decrease in breast cancer-specific mortality: compared to non-drinkers, drinking more than 3 cups of coffee a day corresponds to a 25% reduction in the risk of death.
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Eur J Cancer: Hormone replacement therapy increases the risk of breast cancer in BRCA mutation carriers over 45 years old by 3 times!
Time of Update: 2021-03-30
8)In summary, among BRCA1/BRCA2 mutation carriers, women over 45 years of age who use hormone replacement therapy short-term after salpingo-oophorectomy have a three-fold increase in breast cancer risk .
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CStone Pharmaceuticals announces that China’s first selective RET inhibitor Pugeta® (Platinib Capsules) has been approved, providing new treatment options for lung cancer patients
Time of Update: 2021-03-30
(Platinib Capsules) As a national first-class new drug, it is used for the treatment of locally advanced or metastatic non-small cell lung cancer (NSCLC) adult patients who have previously received platinum-containing chemotherapy for transfection rearrangement (RET) gene fusion positive treatment.
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Nature: Bacteria may contribute to the anti-cancer immune response
Time of Update: 2021-03-30
The key new discovery is that these peptides are displayed on the surface of cancer cells by HLA protein complexes-these complexes exist on the membranes of all cells in our body and play a role in regulating immune responses.
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Nat Commun: The important role and therapeutic potential of PRAK in tumor metastasis
Time of Update: 2021-03-30
Knockout of the Prak gene will inhibit the distant metastasis of the tumor but will not affect the growth of the primary tumorIt is worth noting that the pharmacological inactivation of PRAK with clinically relevant inhibitors can reproduce the anti-metastatic effect of knocking out Prak, thus highlighting the therapeutic potential of targeting PRAK in the control of tumor metastasis.
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JCO: The efficacy of nivolumab combined with ipilimumab in maintenance treatment of advanced small cell lung cancer
Time of Update: 2021-03-30
Further analysis showed that compared with placebo, there was a difference in the progression-free survival of patients in the nivouliu combined with ipilimumab treatment group (HR=0.
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J Immunother Cancer: Camrelizumab combined with apatinib in the treatment of advanced liver cancer
Time of Update: 2021-03-30
Immune checkpoint inhibitors in combination with anti angiogenesis generator is reasonable strategy to treat a variety of malignant tumors of immune vesselsThis study is a multi-cohort phase Ib/II trial to evaluate the effect of human PD-1 monoclonal antibody Camrelizumab combined with apatinib in the treatment of advanced PLC.
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Br J Cancer: The added value of H2 antagonist ranitidine during paclitaxel treatment
Time of Update: 2021-03-30
Prevention This study aims to compare the incidence of HSR reactions between standard regimens including ranitidine and regimens without ranitidine during paclitaxel treatment.
This study aims to compare the incidence of HSR reactions between standard regimens including ranitidine and regimens without ranitidine during paclitaxel treatment.
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How can scientists help effectively fight cancer by stimulating the host's immune system?
Time of Update: 2021-03-30
Recently, in a research report entitled "Cell-Based Identification of New IDO1 Modulator Chemotypes" published in the international journal Angewandte Chemie International Edition , scientists from the Max Planck Society in Germany and other institutions developed a new type of A cell-based detection system to identify immunomodulatory mediators.
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CAR-M therapy is first used in human research
Time of Update: 2021-03-30
A few days ago, Carisma Therapeutics announced that it has completed the first patient administration of its chimeric antigen receptor macrophage (CAR-M) therapy CT-0508 in a phase I multi-center clinical trial.
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Br J Cancer: ABCSG-34 clinical trial reveals the effect of neoadjuvant therapy on breast cancer
Time of Update: 2021-03-30
RCB 0/1 rate and pCR rate of patients with conventional and reverse chemotherapyAll in all, the results of the study revealed that pre-treatment with docetaxel did not improve chemotherapy activity or tolerability.
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Br J Cancer: Even if the weight is normal, body fat indicators are also related to the risk of cancer
Time of Update: 2021-03-30
1038/s41416-020-01210-y">The association of body fat composition with risk of breast, endometrial, ovarian and colorectal cancers among normal weight participants in the UK Biobank .
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JCO: Lower dose, better efficacy-Tamoxifen benefits more women!
Time of Update: 2021-03-30
5 mg of tamoxifen, the reduction in breast density was equivalent to that of the standard dose of 20 mg, but with fewer side effects.
5 mg of tamoxifen, the reduction in breast density was equivalent to that of the standard dose of 20 mg, but with fewer side effects.
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Br J Cancer: Mandard grade is high: it does not mean that esophageal adenocarcinoma does not respond to chemotherapy
Time of Update: 2021-03-30
Kaplan-Meier analysis of patients' relapse-free survival rateAll in all, the results of the study show that in patients with poor Mandard grade, complete lymph node response can significantly improve patient outcomes.
In patients with poor Mandard grade, complete lymph node response can significantly improve the patient's outcome.
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Nature Cancer: Studies have found that inhibiting EZH2 can activate the dsRNA–STING–interferon stress pathway that enhances the response to PD-1 checkpoint blockade in prostate tumors
Time of Update: 2021-03-30
American researchers Morel, KL, Sheahan, AV, Burkhart, DL and other studies have shown that EZH2 inhibition of prostate cancer model activates a double-stranded RNA-STANG-ISG stress response up-regulated gene, which is involved in antigen expression and Th1 chemokine signaling Reacts with interferon, including programmed cell death protein 1 (PD-L1), which is dependent on spinal activation.
