How can scientists help effectively fight cancer by stimulating the host's immune system?

March 26, 2021 // - Cancer cells often evolve mechanisms to evade the host's immune defenses, and factors that prevent immune escape are often attractive targets for the development of new cancer therapies.

Our immune system is very successful in defending the host body against viruses and bacteria.

A new inhibitor of IDO1—researchers are exploring

Because of its cancer-driven effect, IDO1 has become the focus of scientists' medical research; however, so far, researchers have only achieved certain success in the search for IDO1 inhibitors, and are the first to be tested in clinical trials The IDO1 inhibitor epacadostat has almost no effect in clinical trials.

In the process of drug discovery, experimental testing procedures, so-called detection methods, can often find new disease regulators in libraries of thousands of compounds; therefore, researchers use biochemical assays, if a certain species If the inhibitory effect is shown in the experiment, the biochemical reaction may be damaged; but this method has certain shortcomings and limitations, because the relevant experiment is carried out in the detection tube, not in the natural, natural, In a cellular environment.

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Image source: @MPI of Molecular Physiology

New cell-based testing technology may be able to discover IDO1 inhibitors with different mechanisms of action

In this study, researcher Herbert Waldmann and others have developed a cell-based test technology that can help discover new IDO1 inhibitors to overcome the limitations of cell-free detection.

Reference materials:

[1] Elisabeth Hennes, Philipp Lampe, Lara Dotsch, et al.