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Anlotinib sells for 4 billion yuan. How does China's biopharmaceuticals have a market value of 150 billion...
Time of Update: 2021-03-29
" According to statistics, in the four rounds of centralized procurement, China Biopharmaceuticals has won the bid for nearly 20 varieties, involving large varieties such as entecavir, engligliflozin, azacitidine, and large varieties with sales of more than 3 billion yuan in 2018.
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Professor Zijun Liao: Clinical practice has proven that recombinant human endostatin is effective and safe in the treatment of malignant serous effusion
Time of Update: 2021-03-27
Professor Liao Zijun pointed out that “20%~25% of patients who are newly diagnosed with lung cancer in clinical practice are early stage, 70%~75% are middle-advanced stage, malignant serous effusion is a common comorbidity of middle-advanced stage lung cancer.
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Sci Adv | Zhao Shulin/Zhang Liangliang's research team establishes new methods for photoacoustic imaging and photothermal treatment of tumor growth
Time of Update: 2021-03-27
On March 19, 2021, the Zhao Shulin/Zhang Liangliang research team of Guangxi Normal University University published an online research paper entitled A tumor microenvironment–induced absorption red-shifted polymer nanoparticle for simultaneously activated photoacoustic imaging and photothermal therapy in Science Advances.
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Antibody-drug conjugate enfortumab vedotin prolongs survival of patients with metastatic urothelial carcinoma
Time of Update: 2021-03-27
This article from the NEJM meta-Journal (NEJM Journal Watch) Enfortumab Vedotin Improves Survival in Patients with Heavily Treated Metastatic Urothelial Cancerenfortumab vedotin prolong survival comment author has been heavily pre-treated patients with metastatic urothelial carcinoma: Robert Dreicer, MD, MS, MACP, FASCO In this phase 3 trial, all primary endpoints showed that enfortumab vedotin is more effective than chemotherapy.
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Loratinib was used in NSCLC patients with brain metastases after treatment, and the intracranial ORR reached 51.6%!
Time of Update: 2021-03-27
Recently, researchers announced the results of a multi-cohort study aimed at exploring the efficacy and safety of loratinib in the treatment of advanced NSCLC patients who have progressed through the second-generation ALK-TKI treatment.
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Ascent Pharmaceuticals Nectinib is included in the proposed breakthrough treatment, and it is China's first BCR-ABL targeted CML drug
Time of Update: 2021-03-27
Screenshot source: CDE official website HQP1351 is an original Class 1 new drug under research by Ascent Pharmaceuticals, a new third-generation BCR-ABL tyrosine kinase inhibitor (Tyrosine Kinase Inhibitor, TKI), used to treat first- and second-generation TKI resistance Chronic Myelogenous Leukemia (CML), especially for CML patients with T315I mutation, has a good effect.
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Blockbuster therapy allows early-stage lung cancer patients to "survive without cancer" longer, and it has been launched in China
Time of Update: 2021-03-27
▎Editor of WuXi AppTec's content team On March 22, Genentech, a subsidiary of Roche, announced that its PD-L1 antibody Tecentriq (atezolizumab, atezolizumab) is in the treatment of early stage non-small cell lung cancer NSCLC) patients reached the primary endpoint in a phase 3 clinical trial.
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Don't pick wild mushrooms on the side of the road? But this kind of mushroom is "sweet", is it right to fight cancer and control sugar?
Time of Update: 2021-03-27
Another study published in the Journal of Functional Foods showed that eating white mushrooms can produce subtle changes in the microbial community in the intestines, thereby improving the regulation of glucose in the liver.
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To accurately predict the prognosis of early lung cancer patients <3cm, GGO component analysis is essential
Time of Update: 2021-03-27
*Only for medical professionals to read for reference. According to the eighth edition of TNM staging, what effect does GGO component have on the prognosis of patients? Research background The eight
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JCO: Lower dose, side effects halved, just as effective! Classic breast cancer prevention drugs are expected to benefit more women
Time of Update: 2021-03-27
At the same time, tamoxifen is also approved for the adjuvant treatment of breast cancer, which can significantly reduce the risk of postoperative recurrence.
02598[2] Lower dose of estrogen receptor modulator seems to reduce risk of breast cancer.
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Do you really understand the platinum drugs commonly used in clinical practice?
Time of Update: 2021-03-27
Figure 1 The chemical structure of cisplatin ■ The second-generation platinum-based carboplatin was developed in the 1980s and went on the market in the United States in 1986.
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Pembrolizumab sequential AVD treatment of newly diagnosed cHL has amazing efficacy
Time of Update: 2021-03-27
The preliminary analysis results of the study reported at the 2019 ASH Annual Meeting showed that after patients received PEM and sequential 2-cycle AVD treatment, the complete metabolic remission (CMR) rate according to mid-term PET-CT assessment reached 100%.
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Early tumor screening requires the right remedy
Time of Update: 2021-03-27
4. Liver Cancer Primary liver malignant tumors originate from the epithelial or mesenchymal tissues of the liver, have a high mortality rate, and develop rapidly, and most of them are difficult to control for a long time.
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The latest version of the treatment guidelines for venous thromboembolism in cancer patients
Time of Update: 2021-03-27
Key Points For patients who have received systemic treatment and are judged to be at high (rather than low or moderate) risk of thrombosis, it is recommended that DOAC be used for primary prevention.
American Society of Hematology 2021 guidelines for management of venous thromboembolism: Prevention and treatment in patients with cancer.
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Friends who want to study the feedforward loop quickly look over
Time of Update: 2021-03-27
The effect of microgravity on bone loss and drug screening 1) The author analyzed the gene and miRNA expression in the skeletal system subnet (Figure 6D).
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The upgraded version of "Starve Cancer Cells" is here! Scientists have discovered that a drug can inhibit the growth of melanoma, which is also applicable to other cancers
Time of Update: 2021-03-27
This article is converted Medicine original, reproduced please indicate the source Author: Yun Introduction: Recently, scientists have identified a candidate drug that can prevent cancer cell uptake of glutamine, and can slow the growth of melanoma.
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Diffuse large B-cell lymphoma requires clear factors and efficacy evaluation before treatment
Time of Update: 2021-03-27
In addition, the PET/CT assessment results of DLBCL patients after 2 to 4 cycles of treatment may affect the patient's prognosis.
Therefore, it is not recommended to guide the follow-up treatment of DLBCL based on the results of mid-term PET/CT evaluation outside of clinical trials.
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Inhibitory leukocyte immunoglobulin-like receptors (LILRBs)
Time of Update: 2021-03-27
Image source: Reference 5 Based on the in-depth understanding of the target and the study of the structure, Kai Tu Biology has developed a series of LILRB family proteins, domains, and different polymer forms of the ligand HLA-G protein to help the research of differentiated antibodies.
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Colonoscopy should be done at the age of 45! The Stanford team analyzed the big data of 6 million people and found that the first colonoscopy between the ages of 45-49 is associated with a 50% reduction in the risk of colorectal cancer | Clinical Discovery
Time of Update: 2021-03-27
To talk about medical examinations and tests that make ordinary people "fearful", then gastroscopy colonoscopy is definitely on the list. Singularity cakes are often privately chatted by anxious fri
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See the trick: What should I do if PD-1/PD-L1 immunotherapy drugs are resistant?
Time of Update: 2021-03-27
· Internal reasons for drug resistance: tumor cells are very cunning and will bypass immunotherapy through many mechanisms, such as affecting neoantigen expression, antigen presentation, and affecting immune co-suppressive signals.
