-
Cell: Army Military Medical University found the presence of tumor antigen-specific memory CD8+ T cells in tumor draining lymph nodes
Time of Update: 2022-10-19
。Original link: On October 7, 2022, the international top journal "Cell" published online the important research results completed by the team of Ye Lilin/Xu Lifan and collaborators of the Department of Immunology, School of Basic Medical University of Army Medical University, "The. primordial.
-
J Clin Oncol: Efficacy and safety of the FGFR1-4 inhibitor Rogaratinib in advanced urothelial carcinoma
Time of Update: 2022-10-19
This is a randomized, open-label phase II/III trial in which patients with locally advanced or metastatic urothelial carcinoma who had previously received ≥-line platinum-containing regimen were randomized (1:1) to receive either Rokaratinib (800 mg orally, twice daily, n=87) or chemotherapy (docetaxel 75 mg/m2, paclitaxel 175 mg/m2, or vinflunine 320 mg/m2, n=88) 。 The primary endpoints were overall survival and objective response rate.
-
Radiology: Histopathological value of a deep learning survival prediction model for chest CT in lung adenocarcinoma patients
Time of Update: 2022-10-19
Recently, a study published in the journal Radiology evaluated the association between features extracted from DL survival prediction models and histopathological risk factors by using unsupervised clustering studies, and analyzed the value of these correlations through a series of regression analyses, providing a reference for clinical accurate assessment of the prognosis of lung cancer patients.
-
European Radiology: a nomogram of CT imaging that predicts the prognosis of patients with intrahepatic mass cholangiocarcinoma
Time of Update: 2022-10-19
The imaging-based nomination map was established based on preoperative serum carbohydrate antigen 19-9 and four imaging features (multiple nodules, arterial enhancement pattern, CT-reported lymph node (LN) metastasis, and capsular retraction); Postoperative nomograms are based on imaging-based scoring and three pathological parameters, including tumor differentiation grade, capsular invasion, and LN status.
-
Vaccines for tumors? CDE publishes a draft for comments on clinical trials
Time of Update: 2022-10-19
(Operation: Liu Yuxin) On October 9, the official website of the Center for Drug Evaluation (CDE) of the State Medical Products Administration released the "Technical Guidelines for Clinical Trials of Tumor Therapeutic Vaccines (Draft for Comments)" to further standardize and guide the clinical development of tumor therapeutic vaccine drugs and provide technical specifications for reference.
-
J Clin Oncol: Cancer patients who actively self-monitor have a relatively better prognosis!
Time of Update: 2022-10-19
Patients who completed the overall MWC questionnaire had a much lower risk of emergency department visits (adjusted hazard ratio = 0.
Patients who completed the overall MWC questionnaire had a much lower risk of emergency department visits (adjusted hazard ratio = 0.
-
Resistance mechanism and improvement strategy of CDK4/6 inhibitors in the treatment of breast cancer
Time of Update: 2022-10-19
The emergence of resistance to endocrine therapy has created an urgent need to find new targets for breast cancer treatment, such as cyclin-dependent kinase (CDK) 4/6 inhibitors.
-
Radiology: The value of breast DWI magnetic resonance imaging in predicting preoperative staging of ductal carcinoma in situ
Time of Update: 2022-10-19
The proposed preoperative breast MRI model combines diffusion-weighted imaging and clinicopathological factors to more accurately predict the stage of women with biopsy-confirmed ductal carcinoma in situ.
The proposed preoperative breast MRI model combines diffusion-weighted imaging and clinicopathological factors to more accurately predict the stage of women with biopsy-confirmed ductal carcinoma in situ.
-
Radiology: Application of amide proton metastasis-weighted MRI in predicting histological grade of bladder cancer
Time of Update: 2022-10-19
Pathologic examination after transurethral resection showed no detrusor invasion, and the histological grade of the lesion was lowThis study suggests that amide proton transfer-weighted (APTw) MRI is beneficial in assessing the histological grade of bladder cancer and can provide additional information to improve the diagnostic outcome of diffusion-weighted MRI.
-
Subcutaneous injection of "Herceptin" is available in China, providing opportunities for early-stage and metastatic HER2-positive breast cancer
Time of Update: 2022-10-19
On October 9, according to the NMPA official website, Roche trastuzumab injection (subcutaneous injection) (trade name: Herceptin) was approved for marketing in China for the treatment of patients with early-stage and metastatic HER2-positive breast cancer.
-
Chin Med: Astragalus and Curcuma decoction can inhibit colorectal cancer
Time of Update: 2022-10-19
AR decoction inhibits tumor growth in nude mouse xenograft models:Taken together, the findings provide evidence that AR decoctions inhibit Wnt5/β-catenin signaling and inhibit the development of CRC, a promising traditional drug in the clinical treatment of CRCs. Bian Y, Wang G, Zhou J, Yin G, Liu T, Liang L, Yang X, Zhang W, Ni K, Tang D, Yu Y.
-
Ubiquitination in T cell activation and checkpoint inhibition
Time of Update: 2022-10-19
A large number of studies have shown that ubiquitination exerts a variety of cellular and molecular roles by controlling the function, localization and stability of proteins, and the regulation of ubiquitin-dependent pathways can significantly change the activation of T cells and enhance anti-tumor response.
-
JTO: KRAS mutation, STK11 and KEAP1 mutations in lung adenocarcinoma significantly reduce immune efficacy
Time of Update: 2022-10-19
Since STK11 and KEAP1 mutations often occur co-existing in NSCLC, this study sought to determine whether individual gene mutations independently affect immunotherapy outcomes and to understand whether this effect has the same mechanism of action in KRAS mutations as well as in KRAS wild-type patients.
-
JAMA Oncol: adjuvant capecitabine for advanced nasopharyngeal carcinoma followed by concurrent chemoradiotherapy
Time of Update: 2022-10-19
In summary, the results of this randomized clinical trial showed that adjuvant capecitabine after concurrent chemoradiotherapy was well tolerated in patients with locally advanced nasopharyngeal carcinoma with high-risk factors, and improved survival without treatment failure.
-
JAMA Oncol: incidence of skin adverse events in adjuvant therapy of PI3K inhibitors in cancer patients
Time of Update: 2022-10-19
Subgroup analysis showed a higher incidence of serious skin adverse events (grade ≥ 3) in patients using a combination of Class 1 PI3K inhibitors (OR 6.
Subgroup analysis showed a higher incidence of serious skin adverse events (grade ≥ 3) in patients using a combination of Class 1 PI3K inhibitors (OR 6.
-
MR case discussion: arachnoid cyst
Time of Update: 2022-10-19
【Image Performance】MR showed a cystic mass lesion in the left middle cranial fossa, similar to cerebrospinal fluid signal; The left temporal and frontal lobes are displaced, there is no peripheral edema, MR enhancement shows no strengthening of the lesion, and adjacent sphenoid and temporal bones are deformed.
-
Radiology: The value of preoperative MRI for bilateral synchronous breast cancer screening
Time of Update: 2022-10-19
The patient received radiation therapy followed by 5 years of endocrine therapy, and after 11 years of treatment there was no evidence of local or distant recurrenceThe results of this study suggest that a single breast MRI screening of patients with newly diagnosed breast cancer can improve the detection rate of early-stage synchronous breast cancer and further improve the overall survival of patients.
-
Pathological features and imaging of ovarian goiter
Time of Update: 2022-10-19
Fig. 2 Female, 30 years old, CT non-contrast scanning pelvic cystic solid mass (cystic), with separation, the right side of the separation cyst is uniform and high-density, CT value 78HU; After enhancement, a few strip-like, small nodular solid components were seen in the wall of the left capsule of the partition, which was significantly strengthened, and there was no strengthening in the capsule on both sides of the separation.
-
JCO: Professor Wang Jie's team found that Torpalimab combined with chemotherapy works well in the treatment of non-small cell lung cancer
Time of Update: 2022-10-19
The study investigated the efficacy and safety of Torpalimab (tolipalimab) combination chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC).
The study investigated the efficacy and safety of Torpalimab (tolipalimab) combination chemotherapy as first-line treatment for advanced non-small cell lung cancer (NSCLC).
-
European Radiology: Which drugs should patients with HCC choose for TACE treatment?
Time of Update: 2022-10-19
A study published in the journal European Radiology evaluated the effectiveness and safety of bicycline as a chemotherapy regimen for transcatheter arterial chemoembolization (TACE) for hepatocellular carcinoma (HCC) and compared it with other chemotherapy agents in HCC patients who did not respond to TACE or relapsed after cure.
