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Nature. The neurobiological basis of "sugar addiction".
Time of Update: 2020-07-22
the first author, Chen Huiyu, said: "when we add a chemical substance to the beverage that can specifically activate the 'sugar neurons', the mice actually act as if they were taking the real sugar molecules!" In conclusion, the researchers not only revealed the different neurobiological mechanisms of glycogen and glucose, but also revealed for the first time a circuit of sugar addiction, namely the gut vagal brain pathway.
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Cell Journal: Small glial cell recolonization plays a neuroprotective role in brain injury.
Time of Update: 2020-07-22
in conclusion, we found that microglia regeneration in the early stage of brain injury is beneficial to brain repair through a variety of transgenic mice, and this neuroprotective effect is mediated by the IL6 signaling pathway.
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3 Science articles in 2020. Significant progress has been made, with Wang Liang/Xiao Harvest of Zhejiang University revealing the key role of small glial cells in memory.
Time of Update: 2020-07-22
on February 6, 2020, Wang Lang and Gu Yan of Zhejiang University jointly published a research paper entitled "microglia mediating foraging via complex dependent synaptic elimination" in science, which reported that microglia in hippocampus of healthy adult mice phagocytized synaptic components.
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Nature: Tsinghua Songhai/Shipping reveals a new mechanism for the central body to regulate the development of the cerebral cortex.
Time of Update: 2020-07-22
Centrosome anchoring regulates the mechanical properties of the apical membrane of radial glial cells and Yap signal, resulting in the increase in the number of nerve cells and the expansion of cortical volume.
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Science: Nearly 300 units work together to reveal the role of genes in the cortex.
Time of Update: 2020-07-22
from each sub area of the cortex, there is also a negative genetic correlation between the cortical surface area and the average thickness, that is to say, the gene changes of a certain sub region cause the surface area to increase, but at the same time, it will reduce the thickness.
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Current Biology . . . Lockley group and others used single-cell sequencing to reveal the development mechanism of olfactory neurons in fruit flies.
Time of Update: 2020-07-22
quake team (together as Li Hongjie and Li Tongchao) to publish an article in Current Biology Magazine single cell transcripts reveal different regulatory strategies for olfactory receptor expression and axon Targeting, using single cell sequencing, revealed that neurons coordinate receptor expression and neural connectivity through transcription factors in Drosophila olfactory receptor neurons.
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EMBO J . . . The Rofudu team revealed the dense distribution of Neurexins mediated calcium channels in the pre-synaptic activity area.
Time of Update: 2020-07-22
to sum up, the systematic analysis of calyx of held synapses by researchers shows that neurexins specifically mediates the tight distribution of calcium channels in presynaptic active regions, thus playing a key role in regulating the precision and intensity of synaptic transmission.
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Significant progress has been made. Luo Minmin group to establish a new brain-brain interface to achieve "Avatar"-style cross-rat remote control.
Time of Update: 2020-07-22
based on this discovery, the authors constructed an optical brain brain interface using optical fiber recording and photogenetic activation technology, and realized the high information transmission rate of motion information transmission between two mice, thus proving the possibility of brain brain brain interface to accurately control animal movement across individuals.
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Comprehensive Report: Focusing on the same field of small glial cell synapses, Nature withdraws the article first, science later.
Time of Update: 2020-07-22
let's look at the first question 1) In the original text, through multiple behavioral experiments, the researchers found that 564 mice of 12 weeks old had the phenotypes of aggressive enhancement, anxiety like behavior, social disorder and cognitive impairment, and then intraperitoneal injection of type I interferon receptor targeted monoclonal antibody every four days.
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Brain-machine interface - The Light of Dreams into Real Life (Mind over matter to transform lives) - promotion.
Time of Update: 2020-07-22
the weak visual stimulation paradigm and its discriminative typical pattern matching not only expand the astronaut's operational ability in the space environment, but also the BCI technology developed by the team of Tianjin brain science center is also used for the rehabilitation treatment of stroke patients.
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Nature. Alert! The fidelity of the cerebral cortex is flawed.
Time of Update: 2020-07-22
kriegstein from the University of California, USA, published on nature an online paper entitled "cell stress in continental organizations impairs molecular subtype" Using single cell RNA sequencing (scrna SEQ) technology, it was found for the first time that the development of cerebral cortex was characterized by the mature track of progenitor cells, the appearance of various cell subtypes and the regional specificity of new neurons.
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Sci Adv . . . The Wanyou/Yiming team accurately "deletes" rat-specific memories.
Time of Update: 2020-07-22
based on CRISPR technology, combined with anterograde / retrograde AAV and activity-dependent cell labeling technology, this study realized the gene editing of pathway specific and function specific neuronal subpopulations, accurately controlled the storage and extinction of specific memory in rats, and provided a powerful strategy for analyzing the high-level cognitive function of the brain.
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Nature. The PIK3CA mutation promotes the formation of gliomas by increased neuronal excitability.
Time of Update: 2020-07-22
these mutants drive tumor formation by increasing glypican (GPC) secretion, changing tumor microenvironment, up regulating neuronal excitability and promoting proliferation.
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Nature Fist Overview (IF-33) . Hu Haixuan Team System of Zhejiang University Introduces Emerging Brain Fields: Research Progress of The Outer Karsin (Worth Collecting)
Time of Update: 2020-07-22
In the past decade, interest in the lateral habenular nucleus (LHB) has increased exponentially in the past decade due to new findings concerning its key role in regulating negative motivational behavior and its effect on severe depression.
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Research has revealed the neural mechanisms by which the brain stores information in working memory.
Time of Update: 2020-07-22
further, the researchers found that inhibition of the projection from the medial prefrontal cortex (mPFC) to AAIC (Fig. 2b) also effectively downregulated the behavioral performance level (Fig. 2C) and the proportion of transient neurons in mice, but no consistent change was observed in the proportion of persistent neurons (Fig. 2D).
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Science reveals a new neuroloop DP/DTT-DMH with a faster heartbeat at chronic stress.
Time of Update: 2020-07-22
March 6, 2020, based on the above study Kazuhiro Professor Nakamura's research team (now working in the medical department of Nagoya University, Japan) published an article in science magazine and found an important and previously unknown neural circuit: DP / DTT → DMH drives sympathetic and behavioral responses by connecting the subcortical emotional system to the hypothalamic motor control system.
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The secret of music without borders: a string of mysterious codes in the left and right of the human brain.
Time of Update: 2020-07-22
a research entitled "universality and diversity of human songs" conducted by the science department of the University explored whether music from different cultures has the same characteristics.
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New mechanism of the onset of Alzheimer's disease in Nature: inflammatory small body activation drives Tau pathological changes.
Time of Update: 2020-07-22
nlrp1 and nlrc 4 can induce inflammatory body assembly and cell death independently of ASC.
nlpr3nlrp3 is the sensor of NLRP3 inflammatory bodies (adapter ASC (pycard) and effector molecule (caspase 1)), which is composed of N-terminal PYD domain, central NBD domain and C-terminal LRR domain.
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Science . . . Black matter: the common center of sleep and motor control.
Time of Update: 2020-07-22
in general, the work of Yang Dan's research group revealed that gad2 rather than PV neurons in the reticular area of substantia nigra can promote sleep production, especially the initiation of non REM sleep, and the activation of PV neurons is mainly responsible for the termination of motor state.
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WIREs Developmental Biology . . . Studying the link between cilia and signaling pathways helps to understand nervous system development.
Time of Update: 2020-07-22
Eduardo gigante and Tamara caspery, professors at Emory University School of medicine in Atlanta, recently published a study in wires developmental biology, which suggested that studying the relationship between cilia and signal pathways could help us understand the development of nervous system.
