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Prof. Jiajun Liu: Interpretation of the research progress of geratinib in the treatment of FLT3-mutated R/R AML patients
Time of Update: 2022-11-05
Gilteritinib is an oral, highly specific second-generation type I FMS-like tyrosine kinase 3 (FLT3) inhibitor capable of simultaneously inhibiting FLT3-ITD and FLT3-TKD mutations, and the phase III AD
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Gu Tianning, Hu Yongxian, Zhejiang University, et al.: B-cell malignant tumors recur after CAR-T cell therapy: challenges and future
Time of Update: 2022-11-05
Content introductionChinese Summary:Outline:As a new type of cellular immunotherapy, chimeric antigen receptor T (CAR-T) cell therapy has greatly changed the landscape of cancer treatment, especially in hematologic malignancies.
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【CSCO 2022 Prospect】Application and progress of deep tumor hyperthermia!
Time of Update: 2022-11-04
com/s/qcRRrSfo5ZESYEAsdiH8eQ Humans have long recognized the therapeutic effect of "hyperthermia" on diseases.
com/s/qcRRrSfo5ZESYEAsdiH8eQ Humans have long recognized the therapeutic effect of "hyperthermia" on diseases.
com/s/qcRRrSfo5ZESYEAsdiH8eQ Humans have long recognized the therapeutic effect of "hyperthermia" on diseases.
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"7 years ago, I was told that I had terminal cancer and only had 3 months to live..."
Time of Update: 2022-11-04
Actively cooperating with Professor Zhang's treatment plan, driving to the cancer hospital by himself during late-night radiotherapy, and taking the initiative to take care of transporting his grandson to school during the day, Mr. Wang felt that he was about to "be fine".
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The OP-1250 is fast-track designated by the FDA for patients with ER+/HER2-metastatic breast cancer
Time of Update: 2022-11-04
(1) OP-1250 is being studied as a single drug in a Phase 1/2 clinical trial (NCT04505826);(2) Treatment of patients with recurrent, locally advanced or metastatic ER-positive, HER2-negative breast cancer in combination with Ibrance in a phase 1b trial (NCT35266105).
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Lin Aifu Research Group, Zhejiang University: tumor immune checkpoints and related inhibitors
Time of Update: 2022-11-04
Content introductionChinese Summary:Outline:Immune checkpoint proteins, including programmed cell death protein 1 (PD-1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), can bind to their respective receptors to promote immune escape by blocking the activation signal of immune cells.
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The pancreas is not a sterile organ? Cell subjournal: The presence of microbes in pancreatic tumors predicts a worse prognosis
Time of Update: 2022-11-04
Recent studies have found that bacteria and fungi can metastasize to the pancreas and induce local and systemic changes, thereby promoting the development of pancreatic ductal adenocarcinoma (PDA); The microbiome in the PDA may also develop resistance to treatment; In addition, increasingly diverse microbiomes and tumor neoantigens homologous to microbial peptides were detected in tumors from long-term PDA survivors.
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J Transl Med: High risk of melanoma polygenic is associated with improved patient survival in environments with high UV radiation
Time of Update: 2022-11-04
The results showed that in the meta-analysis of MIA and UKB, two loci were significantly associated with MSS, namely rs41309643 (G allele frequency 1.
The results showed that in the meta-analysis of MIA and UKB, two loci were significantly associated with MSS, namely rs41309643 (G allele frequency 1.
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How to deal with 6 common adverse immunotherapy reactions? Expert support!
Time of Update: 2022-11-04
*For medical professionals only to read the summary: Immunotherapy early diagnosis, stratified treatment key points In recent years, immunotherapy has attracted much attention due to its significant e
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Cancer Cell: Wang Haoyi's team reported that BATF deletion can improve the anti-tumor activity of CAR-T cells
Time of Update: 2022-11-04
Recently, the team of Wang Haoyi, Institute of Zoology, Chinese Academy of Sciences, State Key Laboratory of Stem Cell and Reproductive Biology, and Beijing Institute of Stem Cell and Regenerative Medicine published in the journal Cancer Cell entitled : Research paper on Depletion of BATF in CAR-T cells enhances antitumor activity by inducing resistance against exhaustion and formation of central memory cells.
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One child with H3 K27M mutant diffuse midline glioma with extraaxial metastases
Time of Update: 2022-11-04
PET-CT imaging before and after cabozantinib treatment Conclusion of the study In summary, diffuse midline gliomas with H3 K27M mutant in children with bone, pleural, and lung metastases are rare but can occur at the time of recurrence; The probability of occurrence at the first visit is low; May result in a poor prognosis.
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Eur Urol: Does upfront cytoreductive nephrectomy improve clinical outcomes in patients with metastatic renal cell carcinoma?
Time of Update: 2022-11-04
Recently, researchers from the United States published an article in Eur Urol investigating the relationship between prior CN and clinical outcomes in mRCC patients receiving immune checkpoint inhibitors or targeted therapy.
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Frontiers in Oncology: There will be a radical cure for advanced cancer, and new anti-cancer technologies may be able to eradicate malignant tumors!
Time of Update: 2022-11-04
Figure 1 Research results (Source: Frontiers in Oncology) The researchers eradicated malignancy in mice by combining immunotherapeutic agents with molecular delivery systems that target tumor acidity.
Figure 1 Research results (Source: Frontiers in Oncology) The researchers eradicated malignancy in mice by combining immunotherapeutic agents with molecular delivery systems that target tumor acidity.
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Adv Skin Wound Care: Sanyrene liquid dressing is effective in reducing the incidence of radiation dermatitis
Time of Update: 2022-11-04
A meta-analysis published in Adv Skin Wound Care evaluated the effectiveness of Sanyrene liquid dressing (Urgo Medical) in preventing RD in cancer patients after radiation therapy.
A meta-analysis published in Adv Skin Wound Care evaluated the effectiveness of Sanyrene liquid dressing (Urgo Medical) in preventing RD in cancer patients after radiation therapy.
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J Clin Oncol: Optimal treatment sequence for patients with BRAF V600 mutant metastatic melanoma
Time of Update: 2022-11-04
Secondary endpoints were 3-year OS, objective response rate, duration of response, progression-free survival, crossover feasibility, and safety.
Secondary endpoints were 3-year OS, objective response rate, duration of response, progression-free survival, crossover feasibility, and safety.
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What tools oncologists can use to read 2-generation sequencing (NGS) reports in depth
Time of Update: 2022-11-04
Cancer-specific databases often provide detailed information on the probability and incidence of certain gene sequence variants in different types of tumors, particularly key information about potential targeted therapies, and are often linked to other relevant databases and published literature.
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Adrenal area occupancy in children [?] There are characteristics, need to be identified~
Time of Update: 2022-11-04
or slightly higher signal, uneven signal•Delayed centripetal reinforcement of heterogeneity that can be filled incompletely• Calcifications are common, accounting for about 50%： ， 。 ， ， Cases and related data display:Male, 14 years old, abdominal pain with vomiting for 3 days.
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It's convenient and practical! Do you know this prognostic indicator of renal cell carcinoma?
Time of Update: 2022-11-04
Research backgroundPrognostic Nutrition Index (PNI), a new method for assessing a patient's immune and nutritional status based on serum lymphocyte counts and albumin levels, has been used in several studies to predict the prognosis of patients with renal cell carcinoma (RCC).
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Adv. Sci.: A built-in aptamer reservoir with nuclease-resistant 3D cascade assembled DNA nanoclusters for precision cancer treatment
Time of Update: 2022-11-04
Innovation: Wu Regener's team at Fuzhou University has developed aptamer embedded 3D DNA nanoclusters (Apt-eNC) as intelligent carriers for cancer targeted drug delivery.
comInnovation: Wu Regener's team at Fuzhou University has developed aptamer embedded 3D DNA nanoclusters (Apt-eNC) as intelligent carriers for cancer targeted drug delivery.
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Cancer Cell: Aerobic exercise can reprogram the immune system and enhance anti-tumor immunity
Time of Update: 2022-11-04
Exercise promotes the survival of IL-15-sensitive CD8 T cells and doubles the number of home-based pancreatic ductal adenocarcinoma (PDAC) tumors in mice, resulting in effector T cells that have been shown by other studies to kill cancer cells.
